High-resolution MALDI mass spectrometric imaging of lipids in the mammalian retina

Histochemistry and Cell Biology

Volumn 143, Issue 5, 2015, Pages 453-462

  Ly, Alice ^a   Schöne, Cédrik ^a   Becker, Michael ^b   Rattke, Janine ^b   Meding, Stephan ^a,c   Aichler, Michaela ^a   Suckau, Detlev ^b   Walch, Axel ^a   Hauck, Stefanie M ^a   Ueffing, Marius ^a,d  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b BRUKER DALTONIK GMBH   (Germany)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Hierarchical clustering; High resolution; Mass spectrometric imaging; Retina

Indexed keywords

LIPID; PARAFFIN;

ANIMAL; C57BL MOUSE; CHEMISTRY; CLUSTER ANALYSIS; COMPARATIVE STUDY; CRYOPRESERVATION; CYTOLOGY; LABORATORY DIAGNOSIS; MASS SPECTROMETRY; PIG; PROCEDURES; RETINA; SCANNING ELECTRON MICROSCOPY;

ANIMALS; CLUSTER ANALYSIS; CRYOPRESERVATION; LIPIDS; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; PARAFFIN EMBEDDING; RETINA; SPECIMEN HANDLING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE;

EID: 84938936937     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-014-1303-1     Document Type: Article

References (44)

1. Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Gutierrez D, Koutalos Y, Schey KL, Hanneken A, Crouch RK (2013) Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci 54:5535–5542
2. Alexandrov T, Becker M, Deininger SO, Ernst G, Wehder L, Grasmair M, von Eggeling F, Thiele H, Maass P (2010) Spatial segmentation of imaging mass spectrometry data with edge-preserving image denoising and clustering. J Proteome Res 9:6535–6546
3. Alexandrov T, Meding S, Trede D, Kobarg JH, Balluff B, Walch A, Thiele H, Maass P (2011) Super-resolution segmentation of imaging mass spectrometry data: solving the issue of low lateral resolution. J Proteomics 75:237–245
4. Alexandrov T, Becker M, Guntinas-Lichius O, Ernst G, von Eggeling F (2013) MALDI-imaging segmentation is a powerful tool for spatial functional proteomic analysis of human larynx carcinoma. J Cancer Res Clin Oncol 139:85–95
5. Angel PM, Spraggins JM, Baldwin HS, Caprioli R (2012) Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry. Anal Chem 84:1557–1564
6. Attia AS, Schroeder KA, Seeley EH, Wilson KJ, Hammer ND, Colvin DC, Manier ML, Nicklay JJ, Rose KL, Gore JC, Caprioli RM, Skaar EP (2012) Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI. Cell Host Microbe 11:664–673
7. Balluff B, Rauser S, Meding S, Elsner M, Schone C, Feuchtinger A, Schuhmacher C, Novotny A, Jutting U, Maccarrone G, Sarioglu H, Ueffing M, Braselmann H, Zitzelsberger H, Schmid RM, Hofler H, Ebert MP, Walch A (2011a) MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Am J Pathol 179:2720–2729
8. Balluff B, Schone C, Hofler H, Walch A (2011b) MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications. Histochem Cell Biol 136:227–244
9. Boggio KJ, Obasuyi E, Sugino K, Nelson SB, Agar NY, Agar JN (2011) Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact. Expert Rev Proteomics 8:591–604
10. Buttery RG, Hinrichsen CF, Weller WL, Haight JR (1991) How thick should a retina be? A comparative study of mammalian species with and without intraretinal vasculature. Vision Res 31:169–187
11. Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 69:4751–4760
12. Chaurand P, Schwartz SA, Billheimer D, Xu BJ, Crecelius A, Caprioli RM (2004) Integrating histology and imaging mass spectrometry. Anal Chem 76:1145–1155
13. Chaurand P, Schriver KE, Caprioli RM (2007) Instrument design and characterization for high resolution MALDI-MS imaging of tissue sections. J Mass Spectrom 42:476–489
14. Chaurand P, Cornett DS, Angel PM, Caprioli RM (2011) From whole-body sections down to cellular level, multiscale imaging of phospholipids by MALDI mass spectrometry. Mol Cell Proteomics 10(O110):004259
15. Crossman L, McHugh NA, Hsieh Y, Korfmacher WA, Chen J (2006) Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid Commun Mass Spectrom 20:284–290
16. Deininger SO, Becker M, Suckau D (2010) Tutorial: multivariate statistical treatment of imaging data for clinical biomarker discovery. Methods Mol Biol 656:385–403
17. Deutskens F, Yang J, Caprioli RM (2011) High spatial resolution imaging mass spectrometry and classical histology on a single tissue section. J Mass Spectrom 46:568–571
18. Ergin B, Meding S, Langer R, Kap M, Viertler C, Schott C, Ferch U, Riegman P, Zatloukal K, Walch A, Becker KF (2010) Proteomic analysis of PAXgene-fixed tissues. J Proteome Res 9:5188–5196
19. Grey AC, Crouch RK, Koutalos Y, Schey KL, Ablonczy Z (2011) Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:3926–3933
20. Groseclose MR, Massion PP, Chaurand P, Caprioli RM (2008) High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 8:3715–3724
21. Guduric-Fuchs J, Ringland LJ, Gu P, Dellett M, Archer DB, Cogliati T (2009) Immunohistochemical study of pig retinal development. Mol Vis 15:1915–1928
22. Hankin JA, Barkley RM, Murphy RC (2007) Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom 18:1646–1652
23. Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Nakanishi H, Ohishi K, Nakanishi S, Naito T, Taguchi R, Setou M (2008) Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina. Rapid Commun Mass Spectrom 22:3415–3426
24. Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M (2010) Imaging mass spectrometry with silver nanoparticles reveals the distribution of fatty acids in mouse retinal sections. J Am Soc Mass Spectrom 21:1446–1454
25. Holle A, Haase A, Kayser M, Hohndorf J (2006) Optimizing UV laser focus profiles for improved MALDI performance. J Mass Spectrom 41:705–716
26. Jackson SN, Wang HY, Woods AS (2005) Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS. Anal Chem 77:4523–4527
27. Kaletas BK, van der Wiel IM, Stauber J, Guzel C, Kros JM, Luider TM, Heeren RM (2009) Sample preparation issues for tissue imaging by imaging MS. Proteomics 9:2622–2633
28. Lagarrigue M, Becker M, Lavigne R, Deininger SO, Walch A, Aubry F, Suckau D, Pineau C (2011) Revisiting rat spermatogenesis with MALDI imaging at 20-microm resolution. Mol Cell Proteomics 10:M110 005991
29. Lakkaraju A, Finnemann SC, Rodriguez-Boulan E (2007) The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci 104:11026–11031
30. Luxembourg SL, Mize TH, McDonnell LA, Heeren RM (2004) High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface. Anal Chem 76:5339–5344
31. Ly A, Yee P, Vessey KA, Phipps JA, Jobling AI, Fletcher EL (2011) Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. Invest Ophthalmol Vis Sci 52:9316–9326
32. Masland RH (2001) The fundamental plan of the retina. Nat Neurosci 4(9):877–886
33. Meding S, Balluff B, Elsner M, Schone C, Rauser S, Nitsche U, Maak M, Schafer A, Hauck SM, Ueffing M, Langer R, Hofler H, Friess H, Rosenberg R, Walch A (2012) Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer. J Pathol 228:459–470
34. Parker C, Smith D, Suckau D, Borchers C (2009) Mass spectrometry-based tissue imaging. In: Sensen C, Hallgrímsson B (eds) Advanced imaging in biology and medicine. Springer, Berlin Heidelberg, pp 131–146
35. Poetsch A, Schlusener D, Florizone C, Eltis L, Menzel C, Rogner M, Steinert K, Roth U (2008) Improved identification of membrane proteins by MALDI-TOF MS/MS using vacuum sublimated matrix spots on an ultraphobic chip surface. J Biomol Tech 19:129–138
36. Pol J, Strohalm M, Havlicek V, Volny M (2010) Molecular mass spectrometry imaging in biomedical and life science research. Histochem Cell Biol 134:423–443
37. Rompp A, Spengler B (2013) Mass spectrometry imaging with high resolution in mass and space. Histochem Cell Biol 139:759–783
38. Roy MC, Nakanishi H, Takahashi K, Nakanishi S, Kajihara S, Hayasaka T, Setou M, Ogawa K, Taguchi R, Naito T (2011) Salamander retina phospholipids and their localization by MALDI imaging mass spectrometry at cellular size resolution. J Lipid Res 52:463–470
39. Sadeghi M, Vertes A (1998) Crystallite size dependence of volatilization in matrix-assisted laser desorption ionization. Appl Surf Sci 127:226–234
40. Schwartz SA, Reyzer ML, Caprioli RM (2003) Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J Mass Spectrom 38:699–708
41. Seeley EH, Caprioli RM (2008) Molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci 105:18126–18131
42. Thiery G, Shchepinov MS, Southern EM, Audebourg A, Audard V, Terris B, Gut IG (2007) Multiplex target protein imaging in tissue sections by mass spectrometry-TAMSIM. Rapid Commun Mass Spectrom 21:823–829
43. Thomas A, Charbonneau JL, Fournaise E, Chaurand P (2012) Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. Anal Chem 84:2048–2054
44. Yang J, Caprioli RM (2011) Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution. Anal Chem 83:5728–5734