MALDI-imaging segmentation is a powerful tool for spatial functional proteomic analysis of human larynx carcinoma

Journal of Cancer Research and Clinical Oncology

Volumn 139, Issue 1, 2013, Pages 85-95

  Alexandrov, Theodore ^a,b   Becker, Michael ^c   Guntinas Lichius, Orlando ^d   Ernst, Günther ^d   Von Eggeling, Ferdinand ^d  

^a UNIVERSITY OF BREMEN   (Germany)

^b Steinbeis Innovation Center for Scientific Computing in Life Sciences   (Germany)

^c BRUKER DALTONIK GMBH   (Germany)

^d JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Automatic analysis; Histopathological annotation; Larynx carcinoma; MALDI imaging mass spectrometry; Spatial segmentation

Indexed keywords

ALPHA DEFENSIN; EOSIN; HEMATOXYLIN;

ADULT; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LARYNX CARCINOMA; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMICS; STAINING; TISSUE SECTION; TUMOR DIFFERENTIATION;

ADULT; AGED; CARCINOMA; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; PROTEOME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84872289454     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1303-2     Document Type: Article

References (42)

1. Albrethsen J, Bogebo R, Gammeltoft S, Olsen J, Winther B, Raskov H (2005) Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study. BMC Cancer 5(1):8
2. Alexandrov T, Kobarg JH (2011) Efficient spatial segmentation of large imaging mass spectrometry datasets with spatially aware clustering. Bioinformatics 27(13):i230-i238. doi: 10.1093/bioinformatics/btr246
3. Alexandrov T, Becker M, Deininger SO, Ernst G, Wehder L, Grasmair M, von Eggeling F, Thiele H, Maass P (2010) Spatial segmentation of imaging mass spectrometry data with edge-preserving image denoising and clustering. J Proteome Res 9(12):6535-6546. doi: 10.1021/pr100734z
4. Alexandrov T, Meding S, Trede D, Kobarg JH, Balluff B, Walch A, Thiele H, Maass P (2011) Super-resolution segmentation of imaging mass spectrometry data: solving the issue of low lateral resolution. J Proteomics. doi: 10.1016/j.jprot.2011.08.002
5. Cazares L, Adam B, Ward M, Nasim S, Schellhammer P, Semmes O, Wright GJ (2002) Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry. Clin Cancer Res 8(8):2541-2552
6. Cazares LH, Troyer DA, Wang B, Drake RR, Semmes OJ (2011) MALDI tissue imaging: from biomarker discovery to clinical applications. Anal Bioanal Chem 401(1):17-27. doi: 10.1007/s00216-011-5003-6
7. Chaurand P, Sanders ME, Jensen RA, Caprioli RM (2004) Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections. Am J Pathol 165(4):1057-1068
8. Deininger S, Ebert M, Fütterer A, Gerhard M, Röcken C (2008) MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. J Proteome Res 7(12):5230-5236
9. Deutskens F, Yang J, Caprioli RM (2011) High spatial resolution imaging mass spectrometry and classical histology on a single tissue section. J Mass Spectrom 46(6):568-571. doi: 10.1002/jms.1926
10. Driemel O, Murzik U, Escher N, Melle C, Bleul A, Dahse R, Reichert TE, Ernst G, von Eggeling F (2007) Protein profiling of oral brush biopsies: S100A8 and S100A9 can differentiate between normal, premalignant and tumor cells. Proteomics Clin Appl 1:486-493
11. Driemel O, Escher N, Ernst G, Melle C, von Eggeling F (2010) S100A8 cellular distribution in normal epithelium, hyperplasia, dysplasia and squamous cell carcinoma and its concentration in serum. Anal Quant Cytol Histol 32(4):219-224
12. Escher N, Spies-Weisshart B, Kaatz M, Melle C, Bleul A, Driesch D, Wollina U, von Eggeling F (2006) Identification of HNP3 as a tumour marker in CD4+ and CD4-lymphocytes of patients with cutaneous T-cell lymphoma. Eur J Cancer 42(2):249-255
13. Hermani A, Hess J, De SB, Medunjanin S, Grobholz R, Trojan L, Angel P, Mayer D (2005) Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res 11(14):5146-5152
14. Hermani A, De SB, Medunjanin S, Tessier PA, Mayer D (2006) S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res 312(2):184-197
15. Holle A, Haase A, Kayser M, Hohndorf J (2006) Optimizing UV laser focus profiles for improved MALDI performance. J Mass Spectrom 41(6):705-716. doi: 10.1002/jms.1041
16. Jr G, Cazares L, Leung S, Nasim S, Adam B, Yip T, Schellhammer P, Gong L, Vlahou A (1999) Proteinchip(R) surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures. Prostate Cancer Prostatic Dis 2(5/6):264-276. doi: 10.1038/sj.pcan.4500384
17. Jurchen JC, Rubakhin SS, Sweedler JV (2005) MALDI-MS imaging of features smaller than the size of the laser beam. J Am Soc Mass Spectrom 16(10):1654-1659. doi: 10.1016/j.jasms.2005.06.006
18. Lagarrigue M, Becker M, Lavigne R, Deininger SO, Walch A, Aubry F, Suckau D, Pineau C (2011) Revisiting rat spermatogenesis with MALDI imaging at 20-microm resolution. Mol Cell Proteomics 10(3):M110 005991. doi: 10.1074/mcp.M110.005991
19. Lundy FT, Orr DF, Gallagher JR, Maxwell P, Shaw C, Napier SS, Gerald CC, Lamey PJ, Marley JJ (2004) Identification and overexpression of human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue. Oral Oncol 40(2):139-144
20. Melle C, Ernst G, Schimmel B, Bleul A, Koscielny S, Wiesner A, Bogumil R, Möller U, Osterloh D, Halbhuber K, von Eggeling F (2004) A technical triade for proteomic identification and characterization of cancer biomarkers. Cancer Res 64(12):4099-4104. doi: 10.1158/0008-5472.CAN-03-3807
21. Melle C, Ernst G, Schimmel B, Bleul A, Thieme H, Kaufmann R, Mothes H, Settmacher U, Claussen U, Halbhuber KJ, von Eggeling F (2005) Discovery and identification of alpha-defensins as low abundant, tumor-derived serum markers in colorectal cancer. Gastroenterology 129(1):66-73
22. Moog-Lutz C, Bouillet P, Regnier CH, Tomasetto C, Mattei MG, Chenard MP, Anglard P, Rio MC, Basset P (1995) Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22. Int J Cancer 63(2):297-303
23. Muller CA, Markovic-Lipkovski J, Klatt T, Gamper J, Schwarz G, Beck H, Deeg M, Kalbacher H, Widmann S, Wessels JT, Becker V, Muller GA, Flad T (2002) Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation. Am J Pathol 160(4):1311-1324
24. Opitz F, Melle C, Schenke-Layland K, Degenkolbe I, Martin DP, von Eggeling F, Wahlers T, Stock UA (2004) Protein chip system technology: a powerful tool to analyze expression differences in tissue-engineered blood vessels. Tissue Eng 10(3-4):611-620
25. Paradis V, Degos F, Dargere D, Pham N, Belghiti J, Degott C, Janeau JL, Bezeaud A, Delforge D, Cubizolles M, Laurendeau I, Bedossa P (2005) Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases. Hepatology 41(1):40-47
26. Rauser S, Marquardt C, Balluff B, Deininger S-O, Albers C, Belau E, Hartmer R, Suckau D, Specht K, Ebert MP, Schmitt M, Aubele M, Hofler H, Walch A (2010) Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry. J Proteome Res 9(4):1854-1863
27. Rezende TM, de Souza Freire M, Franco OL (2010) Head and neck cancer: proteomic advances and biomarker achievements. Cancer 116(21):4914-4925. doi: 10.1002/cncr.25245
28. Rompp A, Guenther S, Schober Y, Schulz O, Takats Z, Kummer W, Spengler B (2010) Histology by mass spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging. Angew Chem Int Ed Engl 49(22):3834-3838. doi: 10.1002/anie.200905559
29. Rompp A, Guenther S, Takats Z, Spengler B (2011) Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level. Anal Bioanal Chem 401(1):65-73. doi: 10.1007/s00216-011-4990-7
30. Seeley E, Caprioli R (2008) Molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci USA 105(47):18126-18131. doi: 10.1073/pnas.0801374105
31. Semmes O, Feng Z, Adam B, Banez L, Bigbee W, Campos D, Cazares L, Chan D, Grizzle W, Izbicka E, Kagan J, Malik G, McLerran D, Moul J, Partin A, Prasanna P, Rosenzweig J, Sokoll L, Srivastava S, Thompson I, Welsh M, White N, Winget M, Yasui Y, Zhang Z, Zhu L (2005) Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. Clin Chem 51(1):102-112. doi: 10.1373/clinchem.2004.038950
32. Sobin LGM, Wittekind C (2009) TNM Classification of Malignant Tumours (UICC International Union Against Cancer), 7th edn. Wiley-Blackwell, Oxford
33. Stulik J, Osterreicher J, Koupilova K, Knizek J, Macela A, Bures J, Jandik P, Langr F, Dedic K, Jungblut PR (1999) The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumor mass. Electrophoresis 20(4-5):1047-1054
34. van Remoortere A, van Zeijl RJ, van den Oever N, Franck J, Longuespee R, Wisztorski M, Salzet M, Deelder AM, Fournier I, McDonnell LA (2010) MALDI imaging and profiling MS of higher mass proteins from tissue. J Am Soc Mass Spectr 21(11):1922-1929
35. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J (2007) Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-1049
36. von Eggeling F, Davies H, Lomas L, Fiedler W, Junker K, Claussen U, Ernst G (2000) Tissue-specific microdissection coupled with protein chip array technologies: applications in cancer research. Biotechniques 29(5):1066-1070
37. von Eggeling F, Junker K, Fiedle W, Wollscheid V, Dürst M, Claussen U, Ernst G (2001) Mass spectrometry meets chip technology: a new proteomic tool in cancer research? Electrophoresis 22(14):2898-2902. doi: 10.1002/1522- 2683(200108)22:14<2898:AID-ELPS2898>3.0.CO;2-A
38. von Eggeling F, Melle C, Ernst G (2007) Microdissecting the proteome. Proteomics 7(16):2729-2737
39. Walch A, Rauser S, Deininger SO, Hofler H (2008) MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology. Histochem Cell Biol 130(3):421-434. doi: 10.1007/s00418-008-0469-9
40. Ward DG, Suggett N, Cheng Y, Wei W, Johnson H, Billingham LJ, Ismail T, Wakelam MJ, Johnson PJ, Martin A (2006) Identification of serum biomarkers for colon cancer by proteomic analysis. BrJ Cancer 94(12):1898-1905
41. Wehder L, Ernst G, Crecelius AC, Guntinas-Lichius O, Melle C, Schubert US, von Eggeling F (2010) Depicting the spatial distribution of proteins in human tumor tissue combining SELDI and MALDI imaging and immunohistochemistry. J Histochem Cytochem 58(10):929-937
42. Yong HY, Moon A (2007) Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cells. Arch Pharm Res 30(1):75-81