Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

ACS Medicinal Chemistry Letters

Volumn 6, Issue 8, 2015, Pages 913-918

  Ndubaku, Chudi O ^a   Crawford, Terry D ^a   Chen, Huifen ^a   Boggs, Jason W ^a,c   Drobnick, Joy ^a   Harris, Seth F ^a   Jesudason, Rajiv ^a   McNamara, Erin ^a   Nonomiya, Jim ^a   Sambrone, Amy ^a   Schmidt, Stephen ^a   Smyczek, Tanya ^a   Vitorino, Philip ^a,d   Wang, Lan ^a   Wu, Ping ^a   Yeung, Stacey ^a   Chen, Jinhua ^b   Chen, Kevin ^b   Ding, Charles Z ^b   Wang, Tao ^b   Xu, Zijin ^b   Gould, Stephen E ^a   Murray, Lesley J ^a   Ye, Weilan ^a   more..

^a GENENTECH INC   (United States)

^b WUXI APPTEC   (China)

^c WIL RESEARCH LABORATORIES   (United States)

^d GILEAD SCIENCES   (United States)

Author keywords

Angiogenesis; GNE 495; MAP4K4; naphthyridine; P loop

Indexed keywords

GNE 495; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; IN VIVO STUDY; INTERVENTION STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINAL ANGIOGENESIS;

MUS;

EID: 84938920129     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00174     Document Type: Article

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