MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

Nature

Volumn 519, Issue 7544, 2015, Pages 425-430

  Vitorino, Philip ^a   Yeung, Stacey ^a   Crow, Ailey ^a   Bakke, Jesse ^b   Smyczek, Tanya ^a   West, Kristina ^a   McNamara, Erin ^a   Eastham Anderson, Jeffrey ^a   Gould, Stephen ^a   Harris, Seth F ^a   Ndubaku, Chudi ^a   Ye, Weilan ^a  

^a GENENTECH INC   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 1H PYRAZOL 4 YL) 8 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL] 3,5 DIHYDRO 4H PYRIDO[3',2':4,5]PYRROLO[3,2 D]PYRIMIDIN 4 ONE; 2 (3 CYANOPYRIDIN 2 YLAMINO)ACETAMIDE; 2 (5 BROMO 3 CYANOPYRIDIN 2 YLAMINO)ACETAMIDE; 3 AMINO 5 BROMO 1H PYRROLO[2,3 B]PYRIDINE 2 CARBOXYLIC ACID AMIDE; 4 CHLORO 2 (1 METHYL 1H PYRAZOL 4 YL) 8 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL] 5H PYRIDO[3',2':4,5]PYRROLO[3,2 D]PYRIMIDINE; 4 METHYL 2 (1 METHYL 1H PYRAZOL 4 YL) 8 [4 (4 METHYLPIPERAZIN 1 YL)PHENYL] 5H PYRIDO[3',2':4,5]PYRROLO[3,2 D]PYRIMIDINE; 5 BROMO 3 [(1 METHYL 1H PYRAZOLE 4 CARBONYL)AMINO] 1H PYRROLO[2,3 B]PYRIDINE 2 CARBOXYLIC ACID AMIDE; 5 FLUORO 2 (3 FLUOROPHENYL)PYRIDINE; 5 FLUORO 2 (3 FLUOROPHENYL)PYRIDINE 1 OXIDE; 8 AMINO N [1 (CYCLOPROPANECARBONYL)AZETIDIN 3 YL] 2 (3 FLUOROPHENYL) 1,7 NAPHTHYRIDINE 5 CARBOXAMIDE; 8 BROMO 2 (1 METHYL 1H PYRZOL 4 YL) 3,5 DIHYDRO 4H PYRIDO[3',2':4,5]PYRROLO[3,2 D]PYRIMIDIN 4 ONE; ANGIOGENESIS INHIBITOR; BETA1 INTEGRIN; DIETHYL 2 [2 CYANO 6 (3 FLUOROPHENYL)PYRIDIN 3 YL]MALONATE; ERYTHROCYTE BAND 4.1 PROTEIN; ETHYL 2 [2 CYANO 6 (3 FLUOROPHENYL)PYRIDIN 3 YL] 3 (DIMETHYLAMINO)ACRYLATE; ETHYL 2 [2 CYANO 6 (3 FLUOROPHENYL)PYRIDIN 3 YL]MALONATE; EZRIN; INTEGRIN; MAP4K4 PROTEIN; MAP4K4 PROTEIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MOESIN; PROTEIN SERINE THREONINE KINASE; RADIXIN; SMALL INTERFERING RNA; SMALL MOLECULE TRANSPORT AGENT; TALIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERY LATE ACTIVATION ANTIGEN 5; ACTIN BINDING PROTEIN; ALPHA1 INTEGRIN; MAP4K4 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL PEPTIDE;

CHEMICAL BINDING; EPISTASIS; GENE EXPRESSION; INHIBITOR; MEMBRANE; MOLECULAR ANALYSIS; MOTILITY; RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; EPISTASIS; FOCAL ADHESION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE BIOLOGY; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; CELL MOTION; CELL SHAPE; CHEMISTRY; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PHOSPHORYLATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD29; CELL MEMBRANE; CELL MOVEMENT; CELL SHAPE; ENDOTHELIAL CELLS; EPISTASIS, GENETIC; FOCAL ADHESIONS; HUMANS; INTEGRIN ALPHA1; INTEGRINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICROFILAMENT PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TALIN;

EID: 84925798972     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14323     Document Type: Article

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