Cutting edge: Hypoxia-inducible factor 1 negatively regulates Th1 function

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1372-1376

  Shehade, Hussein ^a   Acolty, Valérie ^a   Moser, Muriel ^a   Oldenhove, Guillaume ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HEMAGGLUTININ; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 21; INTERLEUKIN 6; STAT3 PROTEIN; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR T BET; CYTOKINE; HYPOXIA INDUCIBLE FACTOR 1;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL FATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CYTOLOGY; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CELL DIFFERENTIATION; CELL HYPOXIA; CELLS, CULTURED; CYTOKINES; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOMODULATION; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 84938917853     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402552     Document Type: Article

References (19)

1. Thiel, M., C. C. Caldwell, S. Kreth, S. Kuboki, P. Chen, P. Smith, A. Ohta, A. B. Lentsch, D. Lukashev, and M. V. Sitkovsky. 2007. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PLoS One 2: e853.
2. Karhausen, J., G. T. Furuta, J. E. Tomaszewski, R. S. Johnson, S. P. Colgan, and V. H. Haase. 2004. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 114: 1098-1106.
3. Colgan, S. P., and C. T. Taylor. 2010. Hypoxia: an alarm signal during intestinal inflammation. Nat. Rev. Gastroenterol. Hepatol. 7: 281-287.
4. Wang, G. L., B. H. Jiang, E. A. Rue, and G. L. Semenza. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92: 5510-5514.
5. Greer, S. N., J. L. Metcalf, Y. Wang, and M. Ohh. 2012. The updated biology of hypoxia-inducible factor. EMBO J. 31: 2448-2460.
6. Pearce, E. L. 2010. Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 22: 314-320.
7. Frauwirth, K. A., J. L. Riley, M. H. Harris, R. V. Parry, J. C. Rathmell, D. R. Plas, R. L. Elstrom, C. H. June, and C. B. Thompson. 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity 16: 769-777.
8. McNamee, E. N., D. Korns Johnson, D. Homann, and E. T. Clambey. 2013. Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol. Res. 55: 58-70.
9. Dang, E. V., J. Barbi, H.-Y. Yang, D. Jinasena, H. Yu, Y. Zheng, Z. Bordman, J. Fu, Y. Kim, H.-R. Yen, et al. 2011. Control of T(H)17/T(reg) balance by hypoxia-inducible factor. Cell 146: 772-784.
10. Shi, L. Z., R. Wang, G. Huang, P. Vogel, G. Neale, D. R. Green, and H. Chi. 2011. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208: 1367-1376.
11. Clambey, E. T., E. N. McNamee, J. A. Westrich, L. E. Glover, E. L. Campbell, P. Jedlicka, E. F. de Zoeten, J. C. Cambier, K. R. Stenmark, S. P. Colgan, and H. K. Eltzschig. 2012. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl. Acad. Sci. USA 109: E2784-E2793.
12. Yang, X. O., A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong. 2007. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282: 9358-9363.
13. Xu, Q., J. Briggs, S. Park, G. Niu, M. Kortylewski, S. Zhang, T. Gritsko, J. Turkson, H. Kay, G. L. Semenza, et al. 2005. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24: 5552-5560.
14. Kane, A., E. K. Deenick, C. S. Ma, M. C. Cook, G. Uzel, and S. G. Tangye. 2014. STAT3 is a central regulator of lymphocyte differentiation and function. Curr. Opin. Immunol. 28: 49-57.
15. Caldwell, C. C., H. Kojima, D. Lukashev, J. Armstrong, M. Farber, S. G. Apasov, and M. V. Sitkovsky. 2001. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J. Immunol. 167: 6140-6149.
16. Higashiyama, M., R. Hokari, H. Hozumi, C. Kurihara, T. Ueda, C. Watanabe, K. Tomita, M. Nakamura, S. Komoto, Y. Okada, et al. 2012. HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis. J. Leukoc. Biol. 91: 901-909.
17. Vuillefroy de Silly, R., L. Ducimetière, C. Yacoub Maroun, P.-Y. Dietrich, M. Derouazi, and P. R. Walker. 2015. Phenotypic switch of CD8 + T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells. Eur. J. Immunol. DOI: 10.1002/eji.201445284.
18. Naundorf, S., M. Schröder, C. Höflich, N. Suman, H.-D. Volk, and G. Grütz. 2009. IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells. Eur. J. Immunol. 39: 1066-1077.
19. Jankovic, D., M. C. Kullberg, C. G. Feng, R. S. Goldszmid, C. M. Collazo, M. Wilson, T. A. Wynn, M. Kamanaka, R. A. Flavell, and A. Sher. 2007. Conventional T-bet(+)Foxp3(2) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204: 273-283.