Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: A systematic review

British Journal of Sports Medicine

Volumn 49, Issue 16, 2015, Pages 1050-1055

  Gardner, Andrew J ^a   Tan, Can Ozan ^b,c   Ainslie, Philip N ^d,e   Van Donkelaar, Paul ^f   Stanwell, Peter ^g   Levi, Christopher R ^a   Iverson, Grant L ^b,c  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d and Vascular Health   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^g UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; BRAIN CIRCULATION; BRAIN CONCUSSION; CASE CONTROL STUDY; ECHOGRAPHY; FEMALE; HUMAN; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SPORT INJURY; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; YOUNG ADULT;

ADOLESCENT; ADULT; ATHLETIC INJURIES; BRAIN CONCUSSION; CASE-CONTROL STUDIES; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; MALE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; YOUNG ADULT;

EID: 84938835069     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2014-093901     Document Type: Review

References (48)

1. Giza C, Kutcher JS, Ashwal S, et al. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the guideline development subcommittee of the American Academy of Neurology. Neurology 2013;80:2250-7.
2. McCrory P, Meeuwisse WH, Aubry M, et al. Consensus statement on concussion in sport: the 4th international conference on concussion in sport held in Zurich, November 2012. Br J Sports Med 2013;47:250-8.
3. Harmon KG, Drezner JA, Harmon KG, et al. American Medical Society for Sports Medicine position statement: concussion in sport. Br J Sports Med 2013;47:15-26.
4. Macciocchi S, Barth J, Alves W, et al. Neuropsychological functioning and recovery after mild head injury in collegiate athletes. Neurosurgery 1996;39:510-14.
5. McCrea M, Kelly JP, Randolph C, et al. Immediate neurocognitive effects of concussion. Neurosurgery 2002;50:1032-40.
6. Bleiberg J, Cernich AN, Cameron K, et al. Duration of cognitive impairment after sports concussion. Neurosurgery 2004;50:1073-8.
7. Warden DL, Bleiberg J, Cameron KL, et al. Persistent prolongation of simple reaction time in sports concussion. Neurology 2001;57:524-6.
8. McCrea M, Guskiewicz K, Randolph C, et al. Incidence, clinical course, and predictors of prolonged recovery time following sport-related concussion in high school and college athletes. J Int Neuropsychol Soc 2013;19:22-33.
9. Willer B, Leddy JJ. Management of concussion and post-concussion syndrome. Curr Treat Options Neurol 2006;8:415-26.
10. Ainslie PN, Duffin J. Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 2009;296:1473-95.
11. Enevoldsen EM, Jensen FT. Autoregulation and CO2 responses of cerebral blood flow in patients with acute severe head injury. J Neurosurg 1978;48:689-703.
12. Lee JH, Kelly DF, Oertel M, et al. Carbon dioxide reactivity, pressure autoregulation, and metabolic suppression reactivity after head injury: a transcranial Doppler study. J Neurosurg 2001;95:222-32.
13. Golding EM, Steenberg ML, Contant CFJ, et al. Cerebrovascular reactivity to CO(2) and hypotension after mild cortical impact injury. Am J Physiol 1999;277(4 Pt 2):H1457-66.
14. Len TK, Neary JP, Asmundson GJ, et al. Cerebrovascular reactivity impairment after sport-induced concussion. Med Sci Sports Exerc 2011;43:2241-8.
15. Chan ST, Tam Y, Lai CY, et al. Transcranial Doppler study of cerebrovascular reactivity: are migraineurs more sensitive to breath-hold challenge? Brain Res 2009;1291:53-9.
16. Jørgensen LG, Perko M, Hanel B, et al. Middle cerebral artery flow velocity and blood flow during exercise and muscle ischemia in humans. J Appl Physiol 1992;72:1123-32.
17. Secher NH, Seifert T, Van Lieshout JJ. Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 2008;104:306-14.
18. Lynch DR, Dawson TM. Secondary mechanisms in neuronal trauma. Curr Opin Neurol 1994;7:510-16.
19. Clark RS, Kochanek PM, Schwarz MA, et al. Inducible nitric oxide synthase expression in cerebrovascular smooth muscle and neutrophils after traumatic brain injury in immature rats. Pediatr Res 1996;39:784-90.
20. Cobbs CS, Fenoy A, Bredt DS, et al. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Res 1997;751:334-8.
21. Gahm C, Holmin S, Mathiesen T. Temporal profiles and cellular sources of three nitric oxide synthase isoforms in the brain after experimental contusion. Neurosurgery 2000;46:169-77.
22. Lu YC, Liu S, Gong QZ, et al. Inhibition of nitric oxide synthase potentiates hypertension and increases mortality in traumatically brain-injured rats. Mol Chem Neuropathol 1997;30:125-37.
23. Mesenge C, Verrecchia C, Allix M, et al. Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors. J Neurotrauma 1996;13:209-14.
24. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
25. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982;57:769-74.
26. Gardner A, Kay-Lambkin F, Stanwell P, et al. A systematic review of diffusion tensor imaging findings in sports-related concussion. J Neurotrauma 2012;29:2521-38.
27. Gardner A, Iverson GL, Stanwell P. A systematic review of proton magnetic resonance spectroscopy findings in sport-related concussion. J Neurotrauma 2014;31:1-18.
28. Gardner A, Iverson GL, Levi CR, et al. A systematic review of concussion in rugby league. Br J Sports Med 2014. Published Online First.
29. Gardner AJ, Iverson GL, Williams WH, et al. A systematic review and meta-analysis of concussion in Rugby union. Sports Med 2014, Published Online First.
30. Bailey DM, Jones DW, Sinnott A, et al. Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers. Clin Sci (Lond) 2013;124:177-89.
31. Len TK, Neary JP, Asmundson GJG, et al. Serial monitoring of CO2 reactivity following sport concussion using hypocapnia and hypercapnia. Brain Inj 2013;27:346-53.
32. Jordan J, Shannon JR, Diedrich A, et al. Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension 2000;36:383-8.
33. Moppett IK, Wild MJ, Sherman RW, et al. Effects of ephedrine, dobutamine and dopexamine on cerebral haemodynamics: transcranial Doppler studies in healthy volunteers. Br J Anaesth 2004;92:39-44.
34. Schroeder T, Schierbeck J, Howardy P, et al. Effect of labetalol on cerebral blood flow and middle cerebral arterial flow velocity in healthy volunteers. Neurol Res 1991;13:10-12.
35. Karasawa A, Kumada Y, Yamada K, et al. Protective effect of flunarizine against cerebral hypoxia-anoxia in mice and rats. J Pharmacobiodyn 1982;5:295-300.
36. Czernicki Z, Jurkiewicz J, Bojanowski K, et al. Effects of the calcium channel blockers Dotarizine and Flunarizine on cerebrovascular reactivity. J Neurol Sci 1996;143:60-3.
37. Czernicki Z, Kuridze N, Jurkiewicz J, et al. The effect of Dotarizine (Ca2+ channel blocker) on cerebral vessel reactivity in animals subjected to hyperventilation and anoxia. Acta Neurochir Suppl 1997;70(Suppl):209-11.
38. Oishi M, Niimi T, Takagi S, et al. Chemical control of cerebral circulation. Modification by a new vasodilator (YC-93). J Neurol Sci 1978;36:403-10.
39. Takenaka M, Iida H, Iida M, et al. The comparative effects of prostaglandin E1 and nicardipine on cerebral microcirculation in rabbits. Anesth Analg 2003;96:1139-44.
40. Endoh H, Honda T, Komura N, et al. Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. J Clin Anesth 1999;11:545-9.
41. Kawaguchi M, Furuya H, Kurehara K, et al. Effects of nicardipine on cerebral vascular responses to hypocapnia and blood flow velocity in the middle cerebral artery. Stroke 1991;22:1170-2.
42. Abe K, Iwanaga H, Shimada Y, et al. The effect of nicardipine on carotid blood flow velocity, local cerebral blood flow, and carbon dioxide reactivity during cerebral aneurysm surgery. Anesth Analg 1993;76:1227-33.
43. Schmetterer L, Findl O, Strenn K, et al. Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans. Am J Physiol 1997;273(6 Pt 2):2005-12.
44. Zimmermann C, Haberl RL. L-arginine improves diminished cerebral CO2 reactivity in patients. Stroke 2003;34:643-7.
45. Lavi S, Gaitini D, Milloul V, et al. Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction. Am J Physiol Heart Circ Physiol 2006;291:1856-61.
46. Makdissi M, Davis G, Jordan B, et al. Revisiting the modifiers: how should the evaluation and management of acute concussions differ in specific groups? Br J Sports Med 2013;47:314-20.
47. Becelewski J, Pierzchala K. Cerebrovascular reactivity in patients with mild head injury. Neurol Neurochir Pol 2003;37:339-50.
48. Mossberg KA, Ayala D, Baker T, et al. Aerobic capacity after traumatic brain injury: comparison with a nondisabled cohort. Arch Phys Med Rehabil 2007;88:315-20.