Inhibition of nitric oxide synthase potentiates hypertension and increases mortality in traumatically brain-injured rats

Molecular and Chemical Neuropathology

Volumn 30, Issue 1-2, 1997, Pages 125-137

  Lu, Yi Cheng ^a   Liu, Shanliang ^a   Gong, Qin Zhi ^a   Hamm, Robert J ^a   Lyeth, Bruce G ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

blood pressure; fluid percussion; L NAME; morbidity; mortality; rat; traumatic brain injury

Indexed keywords

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BRAIN INJURY; CARDIOVASCULAR PARAMETERS; COGNITIVE DEFECT; ENZYME INHIBITION; HYPERMETABOLISM; HYPERTENSION; MALE; MORTALITY; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION;

ANIMALIA;

EID: 0031052459     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815154     Document Type: Article

References (44)

1. Ashwal S., Cole D. J., Osborne T. N., and Pearce W. J. (1993) Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model. J. Neurosurg. Anesthesiol. 5, 241-249.
2. Bouma G. J. and Muizelaar J. P. (1992) Cerebral blood flow, cerbral blood volume, and cerebrovascular reactivity after severe head injury. J. Neurotrauma 9 (Suppl. 1), S333-S348.
3. Buchanan J. E. and Phillis J. W. (1993) The role of nitric oxide in the regulation of cerebral blood flow. Brain Res. 610, 248-255.
4. Buisson A., Plotkine M., and Boulu R. G. (1992) The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal ischemia. Br. J. Pharmacol. 106, 766-767.
5. Bullock R., Teasdale G. M., Kotake A., Stewart L., and Wagstaff A. (1994) Experience with the glutamate antagonist CGS19755 in severe human head injury: Evidence for ICP lowering effect, in Intracranial Pressure IX (Nagai H., Kamiya K., and Ishii S., eds), Springer-Verlag, Tokyo, pp. 238-241.
6. Bullock R., Zauner A., Tsuji O., Woodward J J., Marmarou A. T., and Young H. F. (1995) Patterns of excitatory amino acid release and ionic flux after severe human head trauma, in Neurochemical Monitoring in the Intensive Care Unit (Tsubokawa T., Marmarou A., Robertson C., and Teasdale G., eds), Springer-Verlag, Tokyo, pp. 64-71.
7. Chi O. Z., Wei H. M., Sinha A. K., and Weiss H. R. (1994) Effects of inhibition of nitric oxide synthase on blood-brain barrier transport in focal cerebral ischemia. Pharmacology 48, 367-373.
8. Dawson V. L., Dawson T. M., Bartley D. A., Uhl G. R., and Snyder S. H. (1993) Mechanisms of nitric oxide mediated neurotoxicity in primary brain cultures. J. Neurosci. 13, 2651-2661.
9. Dirnagl U., Lindauer U., and Villringer A. (1993) Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neurosci. Lett. 149, 43-46.
10. Dixon C. E., Lyeth B. G., Povlishock J. T., Findling R. L., Hamm R. J., Marmarou A., Young H. F., and Hayes R. L. (1987) A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
11. ωL-arginine) on blood pressure and plasma renin. Clin. Exp. Hypertension 15, 819-832.
12. Faden A. I., Demediuk P., Panter S. S., and Vink R. (1989) The role of excitatory amino acid receptors and NMDA receptors in traumatic brain injury. Science 244, 798-800.
13. Faraci F. M., and Breese K. R. (1993) Nitric oxide mediates vasodilation in response to activation of N-Methyl-D-Aspartate receptors in brain. Circ. Res. 72, 476-480.
14. Feldman P. L., Griffith O. W., and Struhr D. J. (1993) The surprising life of nitric oxide. Chem. Eng. News 12, 26-38.
15. Gardiner S. M., Compton A. M., Bennett T., Palmer R. M. J., and Moncada S. (1990) Control of regional blood flow by endothelium-derived nitric oxide. Hypertension 15, 486-492.
16. Hamm R. J., O'Dell D. M., Pike B. R., and Lyeth B. G. (1993) Cognitive impairment following traumatic brain injury: The effect of pre- and post-injury administration of scopolamine and MK-801. J. Cognitive Brain Res. 1, 223-226.
17. Hayes R. L., Jenkins L. W., Lyeth B. G., Balster R. L., Robinson S. E., Miller L. P., Clifton G. L., and Young H. F. (1988) Pretreatment with phencyclidine, an N-methyl-D-aspartate receptor antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury. J. Neurotrauma 5, 259-273.
18. Herberg L. J., Grottick A., and Rose I. C. (1995) Nitric oxide synthesis, epileptic seizures and kindling. Psychopharmacology 119, 115-123.
19. Hirsch D. B., Steiner J. P., Dawson T. M., Mammen A., Hayek E., and Snyder S. H. (1993) Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes. Curr. Biol. 3, 749-754.
20. Ignarro L. J., Buga G. M., Wood K. S., and Chaudhuri G. (1987) Endothelium-derived relaxing factor produced and released from the artery and veins is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265-9269.
21. Jiang J. Y., Lyeth B. G., Clifton G. L., Jenkins L. W., Hamm R. J., Hayes R. L. (1991) Relationship between body and brain temperature in traumatically brain injured rodents. J. Neurosurg. 74, 492-496.
22. Katayama Y., Becker D. P., Tamura T., and Hovda D. A. (1990) Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 884-900.
23. Lewelt W., Jenkins L. W., and Miller J. D. (1982) Effects of experimental fluid-percussion injury of the brain on cerebro-vascular reactivity in hypoxia and to hypercapnia, J. Neurosurg. 56, 332-338.
24. Lindren S., and Rinder L. (1966) Experimental studies on head injury. II. Pressure propagation in "percussion-concussion." Biophysik 3, 174-180.
25. Lyeth B. G., Dixon C. E., Hamm R. J., Jenkins L. W., Young H. F., Stonnington H. H., and Hayes R. L. (1988) Effects of anticholinergic treatment on transient behavioral suppression and physiological responses following concussive brain injury to the rat. Brain Res. 448, 88-97.
26. Lyeth B. G., Jenkins L. W., Hamm R. J., Dixon C. E., Phillips L. L., Clifton G. L., Young H. F., and Hayes R. L. (1990) Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain in the rat. Brain Res. 526, 249-258.
27. Maggio R., Fumagalli F., Donati E., Barbier P., Racagni G., Corsini G. U., and Riva M. (1995) Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. Brain Res. 679, 184-187.
28. McIntosh T. K. (1993) Novel pharmacological therapy in the treatment of experimental traumatic brain injury: A review. J. Neurotrauma 10, 215-261.
29. McIntosh T. K., Vink R., Soares H., Hayes R. L., and Simon R. (1989) Effects of N-methyl-D-aspartate receptor blocker MK-801 on neurologic function after experimental brain injury. J. Neurotrauma 6, 247-259.
30. Mollace V., De Francesco E. Z., and Nistico G. (1992) Evidence that pharmacological manipulations of central L-arginine-NO pathway influence blood pressure and heart rate in rats. Neurosci. Lett. 137, 87-90.
31. Moncada S., Palmer R. M. J., and Higgs E. A. (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
32. Montague P. R., Gancayco C. D., Winn M. J., Marchase R. B., and Friedlander M. J. (1994) Role of NO production in NMDA receptor-mediated neuro transmitter release in cerebral cortex. Science 263, 973-977.
33. Nilsson P., Hillered L., Ponten U., and Ungerstedt U. (1990) Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J. Cereb. Blood Flow Metab. 10, 631-637.
34. Nishakawa T., Kirsch J. R., Koehler R. C., Miyabe M., and Traystman R. J. (1994) Nitric oxide synthase inhibition reduces injury following transient focal ischemia in cats. Stroke 25, 877-885.
35. Palmer R. M. J., Ferrige A. G., and Moncada S. (1987) Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526.
36. Panter S. S. and Faden A. I. (1992) Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury. Neurosci. Lett. 136, 165-168.
37. G-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischema in hyperglycemic rats. Brain Res. 677, 204-212.
38. Rees D.D., Palmer R. M. J., and Moncada S. (1990) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA 86, 3375-3378.
39. Schuman E. M. and Madison D. V. (1994) Nitric oxide and synaptic function. Annu. Rev. Neurosci. 17, 153-183.
40. Tanaka K., Fukuuchi Y., Gomi S., Mihara B., Shirai T., Nogawa S., Nozaki H., and Nagata E. (1993) Inhibition of nitric oxide synthase impairs autoregulation of local cerebral blood flow in the rat. NeuroReport 4, 267-270.
41. Teyler T. J. and DiScenna P. (1987) Long-term potentiation. Annu. Rev. Neurosci. 10, 131-161.
42. ω-Nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils. Neurosci. Lett. 146, 139-142.
43. Yoshino A., Hovda D. A., Kawamata T., Katayama Y., and Becker D. P. (1991) Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: Evidence of a hyper- and subsequent hypometabolic state. Brain Res. 561, 106-119.
44. Zorumski C. F., and Izumi Y. (1993) Nitric oxide and hippocampal synaptic plasticity. Biochem. Pharmacol. 46, 777-785.