Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study

Journal of Pharmacology and Pharmacotherapeutics

Volumn 6, Issue 3, 2015, Pages 142-146

  Rajanandh, Muhasaparur Ganesan ^a   Nageswari, Arcot D ^b   Prathiksha, Giridharan ^c  

^a SRI RAMACHANDRA UNIVERSITY   (India)

^b SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

^c Occupational Disease Centre   (India)

Author keywords

Asthma; budesonide; FEV1; formoterol; Vitamin D3

Indexed keywords

BUDESONIDE; COLECALCIFEROL; FORMOTEROL;

ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL STUDY; COMPARATIVE STUDY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT ATTITUDE; PATIENT COMPLIANCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEVERE PERSISTENT ASTHMA; ST. GEORGE RESPIRATORY QUESTIONNAIRE; SUPPLEMENTATION; SYMPTOM; TREATMENT DURATION;

EID: 84938825813     PISSN: 0976500X     EISSN: 09765018     Source Type: Journal    
DOI: 10.4103/0976-500X.162022     Document Type: Article

References (20)

1. Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado Y, Panettieri R Jr, et al. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br J Pharmacol 2008;155:84-92.
2. Viswanathan R, Prasad M, Thakur AK, Sinha SP, Prakash N, Mody RK, et al. Epidemiology of asthma in an urban population. A random morbidity survey. J Indian Med Assoc 1966;46:480-3.
3. Clifford RL, Knox AJ. Vitamin D - A new treatment for airway remodelling in asthma. Br J Pharmacol 2009;158:1426-8.
4. Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabry͈ová L, et al. The role of 1,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+CD4+T cells. Eur J Immunol 2012;42:2697-708.
5. Gergen PJ, Teach SJ, Mitchell HE, Freishtat RF, Calatroni A, Matsui E, et al. Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. Am J Clin Nutr 2013;97:1228-34.
6. Rajanandh MG, Nageswari AD, Ilango K. Impact of pharmacist provided patient education on knowledge, attitude, practice and quality of life in asthma patients in a South Indian hospital. J Med Sci 2014;14,254-60.
7. Nageswari AD, Rajanandh MG, Priyanka RK, Rajasekhar P. Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study. Perspect Clin Res 2014;5:167-71.
8. Rajanandh MG, Nageswari AD, Ilango K. Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, tiotropium with budesonide: A randomized controlled study. Clin Ther 2014;36:526-33.
9. Rajanandh MG, Nageswari AD, Ilango K. Assessment of various second-line medications in addition to inhaled corticosteroid in asthma patients: A randomized controlled trial. Clin Exp Pharmacol Physiol 2014;41:509-13.
10. Rajanandh MG, Nageswari AD, Ilango K. Effect of two controller medications with inhaled corticosteroid in mild to moderate persistent asthma patients. J Med Sci 2014;14:81-6.
11. Rajanandh MG, Nageswari AD, Ilango K. Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: Which is the best among the second-line treatment? a randomized trial. Clin Ther 2015;37:418-26.
12. Ma JX, Xia JB, Cheng XM, Wang CZ. 1,25-dihydroxyvitamin D3 pretreatment enhances the efficacy of allergen immunotherapy in a mouse allergic asthma model. Chi. Med J (Engl) 2010;123:3591-6.
13. Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Bjorkhem-Bergman L, et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: A randomised and double-blind intervention study. BMJ Open 2012;2. pii: e001663.
14. Black PN, Scragg R. Relationship between serum 25-dihydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005;128:3792-98.
15. Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr 2014;81:650-4.
16. Arshi S, Fallahpour M, Nabavi M, Bemanian MH, Javad-Mousavi SA, Nojomi M, et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol 2014;113:404-9.
17. Iqbal SF, Freishtat RJ. Mechanism of action of vitamin D in the asthmatic lung. J Investig Med 2011;59:1200-2.
18. Hanson C, Armas L, Lyden E, Anderson-Berry A. Vitamin D status and associations in newborn formula-fed infants during initial hospitalization. J Am Diet Assoc 2011;111:1836-43.
19. Rajanandh MG, Nageswari AD, Ilango K. Influence of demographic status on pulmonary function, quality of life and symptom scores in patients with mild to moderate persistent asthma. J Exp Clin Med 2014;6:102-4.
20. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al.; National Heart, Lung, and Blood Institute's AsthmaNet. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: The VIDA randomized clinical trial. JAMA 2014;311:2083-91.