P53 suppresses cell proliferation, metastasis, and angiogenesis of osteosarcoma through inhibition of the PI3K/AKT/mTOR pathway

International Journal of Surgery

Volumn 20, Issue , 2015, Pages 80-87

  Song, Ruipeng ^a   Tian, Ke ^a   Wang, Weidong ^a   Wang, Limin ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Invasion; Mammalian target of rapamycin (mTOR); MG63; Migration; Osteosarcoma; P53; PI3K AKT mTOR pathway; Target therapy

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; ANGIOGENESIS INHIBITOR; COLLAGEN; DRUG COMBINATION; LAMININ; MATRIGEL; MTOR PROTEIN, HUMAN; PROTEOGLYCAN; TARGET OF RAPAMYCIN KINASE;

ACTIN POLYMERIZATION; ANGIOGENESIS; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CAPILLARY TUBE; CELL COUNTING; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METASTASIS; OSTEOBLAST; OSTEOSARCOMA; OSTEOSARCOMA CELL LINE; PATHOGENESIS; PRIORITY JOURNAL; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BONE TUMOR; DRUG COMBINATION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; HUMANS; LAMININ; NEOVASCULARIZATION, PATHOLOGIC; OSTEOSARCOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84938813166     PISSN: 17439191     EISSN: 17439159     Source Type: Journal    
DOI: 10.1016/j.ijsu.2015.04.050     Document Type: Article

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