MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation

Biomedicine and Pharmacotherapy

Volumn 67, Issue 5, 2013, Pages 381-386

  Xu, Jianli ^a   Yao, Qi ^a   Hou, Yu ^a   Xu, Meng ^b   Liu, Sheng ^c   Yang, Longqiu ^d   Zhang, Lei ^e   Xu, Hui ^e  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d FIRST HOSPITAL OF SHIJIAZHUANG   (China)

^e SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Cycle progression; Ect2; MicroRNA233; Osteosarcoma cell; P21; Proliferation

Indexed keywords

EPITHELIAL CELL TRANSFORMING SEQUENCE 2 PROTEIN; MICRORNA 223; PROTEIN; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; DOWN REGULATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BONE NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICRORNAS; OSTEOSARCOMA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION;

EID: 84878372074     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2013.03.013     Document Type: Article

References (22)

1. Mohanty S., Inchara Y.K., Crasta J.A., et al. An unusual case of primary osteosarcoma of the rib in an adult. Indian J Med Paediatr Oncol 2010, 31(1):18-20.
2. Lopez-Martinez J.J., Garcia-Sandoval P.P., Fernandez-Hernandez J.A., et al. Functionality and osteointegration of bone allografts in long bone osteosarcomas. Acta Ortop Mex 2012, 26(1):30-34.
3. Wang Y.H., Xiong J., Wang S.F., et al. Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. Mol Cell Biochem 2010, 341(1-2):225-233.
4. Yang H.L., Dong Y.B., Elliott M.J., et al. Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. Cancer Gene Ther 2001, 8(4):241-251.
5. Kobayashi E., Hornicek F.J., Duan Z. MicroRNA involvement in osteosarcoma. Sarcoma 2012, 2012:359739.
6. Zhao H., Ma B., Wang Y., et al. miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44. Oncol Rep 2013, 10.3892/or.2013.2234.
7. Lynam-Lennon N., Maher S.G., Reynolds J.V. The roles of microRNA in cancer and apoptosis. Biol Rev Camb Philos Soc 2009, 84(1):55-71.
8. Chiaretti S., Messina M., Tavolaro S., et al. Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223. Haematologica 2010, 95(7):1114-1121.
9. Li B.S., Zhao Y.L., Guo G., et al. Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection. PloS One 2012, 7(7):e41629.
10. Karakatsanis A., Papaconstantinou I., Gazouli M., et al. Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog 2011, 52(4):297-303. 10.1002/mc.21864.
11. Li S., Li Z., Guo F., et al. miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma. J Biomed Sci 2011, 18:24.
12. Namlos H.M., Meza-Zepeda L.A., Baroy T., et al. Modulation of the osteosarcoma expression phenotype by microRNAs. PloS One 2012, 7(10):e48086.
13. Jia C.Y., Li H.H., Zhu X.C., et al. MiR-223 suppresses cell proliferation by targeting IGF-1R. PloS One 2011, 6(11):e27008.
14. Iyoda M., Kasamatsu A., Ishigami T., et al. Epithelial cell transforming sequence 2 in human oral cancer. PloS One 2010, 5(11):e14082.
15. Li X., Zhang Y., Zhang H., et al. miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res 2011, 9(7):824-833.
16. Fields A.P., Justilien V. The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul 2010, 50(1):190-200.
17. Niiya F., Tatsumoto T., Lee K.S., et al. Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene 2006, 25(6):827-837.
18. Justilien V., Fields A.P. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene 2009, 28(41):3597-3607.
19. Fortin S.P., Ennis M.J., Schumacher C.A., et al. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Mol Cancer Res 2012, 10(7):958-968.
20. Zhang M.L., Lu S., Zhou L., et al. Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer. Hepatobiliary Pancreat Dis Int 2008, 7(5):533-538.
21. Hirata D., Yamabuki T., Miki D., et al. Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res 2009, 15(1):256-266.
22. Zhang S., Tang Q., Xu F., et al. RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. Mol Cancer Res 2009, 7(4):570-580.