Inhibitory effect of a γ-tocopherol-rich mixture of tocopherols on the formation and growth of LNCaP prostate tumors in immunodeficient mice

Cancers

Volumn 3, Issue 4, 2011, Pages 3762-3772

  Zheng, Xi ^a,b   Cui, Xiao Xing ^a   Khor, Tin Oo ^a   Huang, Ying ^a   DiPaola, Robert S ^b   Goodin, Susan ^b   Lee, Mao Jung ^a   Yang, Chung S ^a,b   Kong, Ah Ng ^a,b   Conney, Allan H ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Immunodeficient mice; Prostate cancer; Tocopherol; Xenograft tumor

Indexed keywords

ALPHA TOCOPHEROL; BETA TOCOPHEROL; CASPASE 3; DELTA TOCOPHEROL; GAMMA TOCOPHEROL; GAMMA TOCOPHEROL RICH MIXTURE OF TOCOPHEROL; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN LNCAP; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG MECHANISM; DRUG MIXTURE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PROSTATE CANCER; PROSTATE TUMOR; PROTEIN EXPRESSION; TUMOR XENOGRAFT; VITAMIN BLOOD LEVEL;

EID: 84055184655     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3043762     Document Type: Article

References (33)

1. Traber, M.G. Vitamin E In Modern Nutrition in Health and Disease; Shils, M.E., Shike, M., Ross, A.C., Caballero, B., Cousins, R.J., Eds.; Lippincott, Williams and Wilkins: Baltimore, MD, USA, 2006; pp. 396-411.
2. Eitenmiller, T.; Lee, J. Vitamin E: Food Chemistry, Composition, and Analysis; Marcel Dekker, Inc.: New York, NY, USA, 2004.
3. Ju, J.; Picinich, S.C.; Yang, Z.; Zhao, Y.; Suh, N.; Kong, A.N.; Yang, C.S. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 2010, 31, 533-542.
4. Taylor, P.R.; Qiao, Y.L.; Abnet, C.C.; Dawsey, S.M.; Yang, C.S.; Gunter, E.W.; Wang, W.; Blot, W.J.; Dong, Z.W.; Mark, S.D. Prospective study of serum vitamin E levels and esophageal and gastric cancers. J. Natl. Cancer Inst. 2003, 95, 1414-1416.
5. Greenwald, P.; Clifford, C.K.; Milner, J.A. Diet and cancer prevention. Eur. J. Cancer 2001, 37, 948-965.
6. Knekt, P.; Aromaa, A.; Maatela, J.; Aaran, R.K.; Nikkari, T.; Hakama, M.; Hakulinen, T.; Peto, R.; Teppo, L. Vitamin E and cancer prevention. Am. J. Clin. Nutr. 1991, 53, 283S-286S.
7. Mahabir, S.; Schendel, K.; Dong, Y.Q.; Barrera, S.L.; Spitz, M.R.; Forman, M.R. Dietary alpha-,beta-, gamma- and delta-tocopherols in lung cancer risk. Int. J. Cancer 2008, 123, 1173-1180.
8. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994, 330, 1029-1035.
9. Lippman, S.M.; Klein, E.A.; Goodman, P.J.; Lucia, M.S.; Thompson, I.M.; Ford, L.G.; Parnes, H.L.; Minasian, L.M.; Gaziano, J.M.; Hartline, J.A.; et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009, 301, 39-51.
10. Wolf, G. Gamma-Tocopherol: An efficient protector of lipids against nitric oxide-initiated peroxidative damage. Nutr. Rev. 1997, 55, 376-378.
11. Wagner, K.H.; Kamal-Eldin, A.; Elmadfa, I. Gamma-tocopherol-An underestimated vitamin? Ann. Nutr. Metab. 2004, 48, 169-188.
12. Jiang, Q.; Christen, S.; Shigenaga, M.K.; Ames, B.N. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr. 2001, 74, 714-722.
13. Grammas, P.; Hamdheydari, L.; Benaksas, E.J.; Mou, S.; Pye, Q.N.; Wechter, W.J.; Floyd, R.A.; Stewart, C.; Hensley, K. Anti-inflammatory effects of tocopherol metabolites. Biochem. Biophys. Res. Commun. 2004, 319, 1047-1052.
14. Reiter, E.; Jiang, Q.; Christen, S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol. Aspects Med. 2007, 28, 668-691.
15. Yu, W.; Park, S.K.; Jia, L.; Tiwary, R.; Scott, W.W.; Li, J.; Wang, P.; Simmons-Menchaca, M.; Sanders, B.G.; Kline, K. RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Lett. 2008, 259, 165-176.
16. Jiang, Q.; Wong, J.; Fyrst, H.; Saba, J.D.; Ames, B.N. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc. Natl. Acad. Sci. USA 2004, 101, 17825-17830.
17. Ju, J.; Hao, X.; Lee, M.J.; Lambert, J.D.; Lu, G.; Xiao, H.; Newmark, H.L.; Yang, C.S. A gammatocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prev. Res. (Phila). 2009, 2, 143-152.
18. Lee, H.J.; Ju, J.; Paul, S.; So, J.Y.; DeCastro, A.; Smolarek, A.; Lee, M.J.; Yang, C.S.; Newmark, H.L.; Suh, N. Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma. Clin. Cancer Res. 2009, 15, 4242-4249.
19. Barve, A.; Khor, T.O.; Nair, S.; Reuhl, K.; Suh, N.; Reddy, B.; Newmark, H.; Kong, A.N. Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. Int. J. Cancer. 2009, 124, 1693-1699.
20. Lambert, J.D.; Lu, G.; Lee, M.J.; Hu, J.; Ju, J.; Yang, C.S. Inhibition of lung cancer growth in mice by dietary mixed tocopherols. Mol. Nutr. Food Res. 2009, 53, 1030-1035.
21. Campbell, S.E.; Stone, W.L.; Lee, S.; Whaley, S.; Yang, H.; Qui, M.; Goforth, P.; Sherman, D.; McHaffie, D.; Krishnan, K. Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer 2006, 6, 13.
22. Gysin, R.; Azzi, A.; Visarius, T. Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. FASEB J. 2002, 16, 1952-1954.
23. Jiang, Q.; Wong, J.; Ames, B.N. Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. Ann. N.Y. Acad. Sci. 2004, 1031, 399-400.
24. Li, G.X.; Lee, M.J.; Liu, A.B.; Yang, Z.; Lin, Y.; Shih, W.J.; Yang, C.S. δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev. Res. (Phila). 2011, 4, 404-413.
25. Devaraj, S.; Leonard, S.; Traber, M.G.; Jialal, I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic. Biol. Med. 2008, 44, 1203-1208.
26. Jiang, Q.; Elson-Schwab, I.; Courtemanche, C.; Ames, B.N. gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc. Natl. Acad. Sci. USA 2000, 97, 11494-11499.
27. Ford, E.S.; Schleicher, R.L.; Mokdad, A.H.; Ajani, U.A.; Liu, S. Distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in the US population. Am. J. Clin. Nutr. 2006, 84, 375-383.
28. Zheng, X.; Cui, X.X.; Avila, G.E.; Huang, M.T.; Liu, Y.; Patel, J.; Kong, A.N.; Paulino, R.; Shih, W.J.; Lin, Y.; et al. Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice. Clin. Cancer Res. 2007, 13, 5480-5487.
29. Zheng, X.; Chang, R.L.; Cui, X.X.; Avila, G.; Huang, M.T.; Liu, Y.; Kong, A.N.; Rabson, A.B.; Conney, A.H. Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells. Int. J. Oncol. 2008, 32, 257-264.
30. Ploszaj, T.; Motyl, T.; Orzechowski, A.; Zimowska, W.; Wareski, P.; Skierski, J.; Zwierzchowski, L. Antiapoptotic action of prolactin is associated with up-regulation of Bcl-2 and down-regulation of Bax in HC11 mouse mammary epithelial cells. Apoptosis 1998, 3, 295-304.
31. Zheng, X.; Chang, R.L.; Cui, X.X.; Avila, G.E.; Hebbar, V.; Garzotto, M.; Shih, W.J.; Lin, Y.; Lu, S.E.; Rabson, A.B.; et al. Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. Clin. Cancer Res. 2006, 12, 3444-3451.
32. Zheng, X.; Chang, R.L.; Cui, X.X.; Avila, G.E.; Lee, S.; Lu, Y.P.; Lou, Y.R.; Shih, W.J.; Lin, Y.; Reuhl, K.; et al. Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice. Cancer Res. 2004, 64, 1811-1820.
33. Zheng, X.; Cui, X.X.; Gao, Z.; Zhao, Y.; Lin, Y.; Shih, W.J.; Huang, M.T.; Liu, Y.; Rabson, A.; Reddy, B.; et al. Atorvastatin and celecoxib in combination inhibits the progression of androgendependent LNCaP xenograft prostate tumors to androgen independence. Cancer Prev. Res. (Phila) 2010, 3, 114-124.