Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Gómez Pérez, Gloria P ^a,b   Legarda, Almudena ^a   Muñoz, Jose ^a   Sim, B Kim Lee ^c   Ballester, María Rosa ^d,e   Dobaño, Carlota ^a   Moncunill, Gemma ^a   Campo, Joseph J ^a,f   Cisteró, Pau ^a   Jimenez, Alfons ^a   Barrios, Diana ^a   Mordmüller, Benjamin ^g   Pardos, Josefina ^a   Navarro, Mireia ^a   Zita, Cecilia Justino ^h   Nhamuave, Carlos Arlindo ^h   García Basteiro, Alberto L ^a,h   Sanz, Ariadna ^a   Aldea, Marta ^a,h   Manoj, Anita ^c   Gunasekera, Anusha ^c   Billingsley, Peter F ^c   Aponte, John J ^a   James, Eric R ^c   Guinovart, Caterina ^a   Antonijoan, Rosa M ^d,e   Kremsner, Peter G ^g   Hoffman, Stephen L ^c   Alonso, Pedro L ^a,h   more..

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c SANARIA INC   (United States)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f Antigen Discovery Inc   (United States)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h Ministérioda Saúde   (Mozambique)

Author keywords

Controlled human malaria infection; Cryopreserved sporozoites; Human challenge infection; Malaria; Plasmodium falciparum

Indexed keywords

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED HUMAN MALARIA INFECTION; CONTROLLED STUDY; CRYOPRESERVATION; DISEASE SEVERITY; EDEMA; ERYTHEMA; FEMALE; FEVER; HEADACHE; HUMAN; INFECTION RATE; MALAISE; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; MYALGIA; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; SPOROZOITE; YOUNG ADULT; ADOLESCENT; ANIMAL; CLINICAL TRIAL; DOSE RESPONSE; IMMUNOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; MIDDLE AGED; PARASITEMIA; PARASITOLOGY; SPAIN; VOLUNTEER;

ADOLESCENT; ADULT; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PARASITEMIA; PLASMODIUM FALCIPARUM; SPAIN; SPOROZOITES; VOLUNTEERS; YOUNG ADULT;

EID: 84938775301     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0817-x     Document Type: Article

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