The Effects of Pretreatment versus de Novo Treatment with Selective Serotonin Reuptake Inhibitors on Short-term Outcome after Acute Ischemic Stroke

Journal of Stroke and Cerebrovascular Diseases

Volumn 24, Issue 8, 2015, Pages 1886-1892

  Siepmann, Timo ^a   Kepplinger, Jessica ^a   Zerna, Charlotte ^a   Schatz, Ulrike ^a   Penzlin, Ana Isabel ^a   Pallesen, Lars Peder ^a   Illigens, Ben Min Woo ^b   Weidner, Kerstin ^a   Reichmann, Heinz ^a   Puetz, Volker ^a   Bodechtel, Ulf ^a   Barlinn, Kristian ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ischemic stroke; neurogenesis; neuroprotection; poststroke SSRI; prestroke SSRI; SSRI

Indexed keywords

CITALOPRAM; ESCITALOPRAM; FLUOXETINE; SEROTONIN UPTAKE INHIBITOR;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; FEMALE; FUNCTIONAL ASSESSMENT; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OUTCOME ASSESSMENT; POSTSTROKE TREATMENT; PRESCRIPTION; PRESTROKE TREATMENT; PRIORITY JOURNAL; RANKIN SCALE; TIME TO TREATMENT; COMPLICATION; CONVALESCENCE; DRUG EFFECTS; LENGTH OF STAY; MIDDLE AGED; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; STROKE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; STROKE;

EID: 84938751482     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2015.04.033     Document Type: Article

References (26)

1. W. Hacke, M. Kaste, E. Bluhmki, and et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N Engl J Med 359 2008 1317 1329
2. A.S. Go, D. Mozaffarian, V.L. Roger, and et al. Heart disease and stroke statistics-2014 update: a report from the American Heart Association Circulation 129 2014 e28 e292
3. F. Chollet, J. Tardy, J.-F. Albucher, and et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial Lancet Neurol 10 2011 123 130
4. G.E. Mead, C.F. Hsieh, R. Lee, and et al. Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery Cochrane Database Syst Rev 11 2012 CD009286
5. S. Zittel, C. Weiller, and J. Liepert Citalopram improves dexterity in chronic stroke patients Neurorehabil Neural Repair 22 2008 311 314
6. M. Acler, E. Robol, A. Fiaschi, and et al. A double blind placebo RCT to investigate the effects of serotonergic modulation on brain excitability and motor recovery in stroke patients J Neurol 256 2009 1152 1158
7. H.D. Schmidt, and R.S. Duman The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behaviour Behav Pharmacol 18 2007 391 418
8. C.M. Lim, S.W. Kim, J.Y. Park, and et al. Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect Neurosci Res 87 2009 1037 1045
9. C. Wiltrout, B. Lang, Y. Yan, and et al. Repairing brain after stroke: a review on post-ischaemic neurogenesis Neurochem Int 50 2007 1028 1041
10. J.E. Malberg, A.J. Eisch, E.J. Nestler, and et al. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 2000 9104 9110
11. F. Chollet, S.C. Cramer, C. Stinear, and et al. Pharmacological therapies in post stroke recovery: recommendations for future clinical trials J Neurol 261 2014 1461 1568
12. J.K. Mortensen, H. Larsson, S.P. Johnsen, and et al. Impact of prestroke selective serotonin reuptake inhibitor treatment on stroke severity and mortality Stroke 45 2014 2121 2123
13. M. Bauer, B.U. Monz, A.L. Montejo, and et al. Prescribing patterns of antidepressants in Europe: results from the Factors Influencing Depression Endpoints Research (FINDER) study Eur Psychiatry 23 2008 66 73
14. H.P. Adams Jr., B.H. Bendixen, L.J. Kappelle, and et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial Stroke 24 1993 35 41
15. A.I. Qureshi, S.A. Chaudhry, B.L. Sapkota, and et al. Discharge destination as a surrogate for Modified Rankin Scale defined outcomes at 3- and 12-months poststroke among stroke survivors Arch Phys Med Rehabil 93 2012 1408 1413
16. D.M. Kerr, R.L. Fulton, K.R. Lees, and et al. Seven-day NIHSS is a sensitive outcome measure for exploratory clinical trials in acute stroke: evidence from the Virtual International Stroke Trials Archive Stroke 43 2012 1401 1403
17. I. Miedema, K.M. Horvath, M. Uyttenboogaart, and et al. Effect of selective serotonin re-uptake inhibitors (SSRIs) on functional outcome in patients with acute ischemic stroke treated with tPA J Neurol Sci 293 2010 65 67
18. L. Santarelli, M. Saxe, C. Gross, and et al. Requirement of hippocampal neurogenesis antidepressant treatments and animal models of depressive-like behaviour Science 301 2003 805 809
19. A.U. Hicks, K. Hewlett, V. Windle, and et al. Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke Neuroscience 146 2007 31 40
20. A. Arvidsson, T. Collin, D. Kirik, and et al. Neuronal replacement from endogenous precursors in the adult brain after stroke Nat Med 8 2002 963 970
21. M. Vaswani, F.K. Linda, and S. Ramesh Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review Prog Neuropsychopharmacol Biol Psychiatry 27 2003 85 102
22. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Arch Gen Psychiatry 54 1997 597 606
23. T. Kirino Delayed neuronal death Neuropathology 20 Suppl 2000 S95 S97
24. F.R. Walker A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? Neuropharmacology 67 2013 304 317
25. M.L. Hackett, and C.S. Anderson Predictors of depression after stroke: a systematic review of observational studies Stroke 36 2005 2296 2301
26. K. Barlinn, J. Kepplinger, V. Puetz, and et al. Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis Neuropsychiatr Dis Treat 11 2014 1 14