Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro Optimization, Ex-vivo and In-vivo Permeation

Pharmaceutical Research

Volumn 32, Issue 9, 2015, Pages 2901-2911

  El Refaie, Wessam M ^a   Elnaggar, Yosra S R ^b   El Massik, Magda A ^a   Abdallah, Ossama Y ^b  

^a Pharos University of Alexandria   (Egypt)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

elastic nanovesicles; gel core; hyaluronic acid; osteoarthritis; transdermal

Indexed keywords

ANTIRHEUMATIC AGENT; HYALURONIC ACID DERIVATIVE; LIPOSOME; NANOCARRIER; SELF ASSEMBLED GEL CORE HYALUOSOME; SELF ASSEMBLED MONOLAYER; UNCLASSIFIED DRUG; BIOMATERIAL; DRUG CARRIER; GEL; HYALURONIC ACID; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG PENETRATION; DRUG STABILITY; ELASTICITY; EX VIVO STUDY; FEMALE; HYDRATION; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; LIPOSOMAL DELIVERY; MALE; MICROSCOPY; MULTIPLE DRUG DOSE; NANOPHARMACEUTICS; NON INVASIVE PROCEDURE; NONHUMAN; PARTICLE SIZE; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TRANSDERMAL DRUG DELIVERY SYSTEM; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; GEL; INTRAARTICULAR DRUG ADMINISTRATION; INTRADERMAL DRUG ADMINISTRATION; OSTEOARTHRITIS; PERMEABILITY; PROCEDURES; SKIN ABSORPTION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ELASTICITY; FEMALE; GELS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; LIPOSOMES; NANOPARTICLES; OSTEOARTHRITIS; PARTICLE SIZE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION;

EID: 84938741225     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1672-8     Document Type: Article

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