Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis

Research in Veterinary Science

Volumn 101, Issue , 2015, Pages 57-62

  Roels, E ^a   Krafft, E ^a   Antoine, N ^a   Farnir, F ^a   Laurila, H P ^b   Holopainen, S ^b   Rajamaki M M ^b   Clercx, C ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Canine idiopathic pulmonary fibrosis; CCL2; CXCL8; Serotonin; VEGF

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; SEROTONIN; VASCULOTROPIN; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULOTROPIN A;

ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOG BREED; FEMALE; FIBROSING ALVEOLITIS; JACK RUSSELL TERRIER; KING CHARLES SPANIEL; LABRADOR RETRIEVER; MALE; MALINOIS BELGIAN SHEPHERD; MALTESE; NONHUMAN; PATHOGENESIS; PROTEIN BLOOD LEVEL; SCOTTISH TERRIER; TERRIER; THROMBOCYTE COUNT; WEST HIGHLAND WHITE TERRIER; ANIMAL; BLOOD; DOG; DOG DISEASE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; SPECIES DIFFERENCE; VETERINARY;

CANIS FAMILIARIS;

ANIMALS; CHEMOKINE CCL2; DOG DISEASES; DOGS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; IDIOPATHIC PULMONARY FIBROSIS; INTERLEUKIN-8; SEROTONIN; SPECIES SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84938723665     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2015.05.020     Document Type: Article

References (54)

1. Ahn M.H., Park B.L., Lee S.H., Park S.W., Park J.S., Kim D.J., Jang A.S., Park J.S., Shin H.K., Uh S.T., Kim Y.K., Kim Y.W., Han S.K., Jung K.S., Lee K.Y., Jeong S.H., Park J.W., Choi B.W., Park I.W., Chung M.P., Shin H.D., Song J.W., Kim D.S., Park C.S., Shim Y.S. A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode. Respiratory Research 2011, 12:73.
2. Alhamad E.H., Cal J.G., Shakoor Z., Almogren A., Alboukai A.A. Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis. BMC Medical Genetics 2013, 14:66.
3. Ando M., Miyazaki E., Ito T., Hiroshige S., Nureki S.I., Ueno T., Takenaka R., Fukami T., Kumamoto T. Significance of serum vascular endothelial growth factor level in patients with idiopathic pulmonary fibrosis. Lung 2010, 188:247-252.
4. Antoniou K.M., Tzouvelekis A., Alexandrakis M.G., Sfiridaki K., Tsiligianni I., Rachiotis G., Tzanakis N., Bouros D., Milic-Emili J., Siafakas N.M. Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis. Chest 2006, 130:982-988.
5. Arkwright P.D., Laurie S., Super M., Pravica V., Schwarz M., Webb A.K., Hutchinson I.V. TGF-β1 genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax 2000, 55:459-462.
6. Arndt J.W., Reynolds C.A., Singletary G.E., Connolly J.M., Levy R.J., Oyama M.A. Serum serotonin concentrations in dogs with degenerative mitral valve disease. Journal of Veterinary Internal Medicine 2009, 23:1208-1213.
7. Baran C.P., Opalek J.M., McMaken S., Newland C.A., O'Brien J.M., Hunter M.G., Bringardner B.D., Monick M.M., Brigstock D.R., Stromberg P.C., Hunninghake G.W., Marsh C.B. Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine 2007, 176:78-89.
8. Borgarelli M., Buchanan J.W. Historical review, epidemiology and natural history of degenerative mitral valve disease. Journal of Veterinary Cardiology 2012, 14:93-101.
9. Capelli A., Di Stefano A., Gnemmi I., Donner C.F. CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. The European Respiratory Journal 2005, 25:701-707.
10. Corcoran B.M., Cobb M., Martin M.W., Dukes-McEwan J., French A., Fuentes V.L., Boswood A., Rhind S. Chronic pulmonary disease in West Highland white terriers. The Veterinary Record 1999, 144:611-616.
11. Coward W.R., Saini G., Jenkins G. The pathogenesis of idiopathic pulmonary fibrosis. Therapeutic Advances in Respiratory Disease 2010, 4:367-388.
12. Cremer S.E., Singletary G.E., Olsen L.H., Wallace K., Haggstrom J., Ljungvall I., Hoglund K., Reynolds C.A., Pizzinat N., Oyama M.A. Serotonin concentrations in platelets, plasma, mitral valve leaflet, and left ventricular myocardial tissue in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine 2014, 28:1534-1540.
13. Crooks M.G., Fahim A., Nassem K.M., Morice A.H., Hart S.P. Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. Plos One 2014, 9:e111347.
14. Cui A., Anhenn O., Theegarten D., Ohshimo S., Bonella F., Sixt S.U., Peters J., Sarria R., Guzman J., Costabel U. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Respiration 2010, 80:372-378.
15. Davis B., Toivio-Kinnucan M., Schuller S., Boudreaux M.K. Mutation in β1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine 2008, 22:540-545.
16. Emad A., Emad V. Increased levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. Toxicology 2007, 240:60-69.
17. Fabre A., Crestani B. Serotonin: a new start for an old friend. Thorax 2010, 65:946-947.
18. Fernandez I.E., Eickelberg O. The impact of TGF-β on lung fibrosis, from targeting to biomarkers. Proceedings of the American Thoracic Society 2012, 9:111-116.
19. Fujiwara A., Kobayashi H., Masuya M., Maruyama M., Nakamura S., Ibata H., Fujimoto H., Ohnishi M., Urawa M., Naito M., Takagi T., Kobayashi T., Gabazza E.C., Takei Y., Taguchi O. Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases. Respirology 2012, 17:693-698.
20. Gallagher A.E., Panciera D.L., Panciera R.J. Hyperphosphatasemia in scottish terriers: 7 cases. Journal of Veterinary Internal Medicine 2006, 20:418-421.
21. Gharaee-Kermani M., Denholm E.M., Phan S.H. Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. The Journal of Biological Chemistry 1996, 271:17779-17784.
22. Heikkilä H.P., Lappalainen A.K., Day M.J., Clercx C., Rajamäki M.M. Clinical, bronchoscopic, histopathologic, diagnostic imaging, and arterial oxygenation findings in West Highland White Terriers with idiopathic pulmonary fibrosis. Journal of Veterinary Internal Medicine 2011, 25:433-439.
23. Heikkilä-Laurila H.P., Rajamäki M.M. Idiopathic pulmonary fibrosis in West Highland white terriers. The Veterinary Clinics of North America. Small Animal Practice 2014, 44:129-142.
24. Inomata M., Kamio K., Azuma A., Matsuda K., Kokuho N., Miura Y., Hayashi H., Nei T., Fujita K., Saito Y., Gemma A. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respiratory Research 2014, 15:16.
25. Johnson V.S., Corcoran B.M., Wotton P.R., Schwarz T., Sullivan M. Thoracic high-resolution computed tomographic findings in dogs with canine idiopathic pulmonary fibrosis. The Journal of Small Animal Practice 2005, 46:381-388.
26. Konigshoff M., Dumitrascu R., Udalov S., Amarie O.V., Reiter R., Grimminger F., Seeger W., Schermuly R.T., Eickelberg O. Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention. Thorax 2010, 65:949-955.
27. Koyama S., Sato E., Haniuda M., Numanami H., Nagai S., Izumi T. Decreased level of vascular endothelial growth factor in bronchoalveolar lavage fluid of normal smokers and patients with pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine 2002, 166:382-385.
28. Krafft E., Heikkilä H.P., Jespers P., Peeters D., Day M.J., Rajamäki M.M., Mc Entee K., Clercx C. Serum and bronchoalveolar lavage fluid endothelin-1 concentrations as diagnostic biomarkers of canine idiopathic pulmonary fibrosis. Journal of Veterinary Internal Medicine 2011, 25:990-996.
29. Krafft E., Laurila H.P., Peters I.R., Bureau F., Peeters D., Day M.J., Rajamäki M.M., Clercx C. Analysis of gene expression in canine idiopathic pulmonary fibrosis. Veterinary Journal 2013, 198:479-486.
30. Krafft E., Lybaert P., Roels E., Laurila H.P., Rajamäki M.M., Farnir F., Myllarniemi M., Day M.J., Mc Entee K., Clercx C. Transforming growth factor beta 1 activation, storage, and signaling pathways in idiopathic pulmonary fibrosis in dogs. Journal of Veterinary Internal Medicine 2014, 28:1666-1675.
31. Ljungvall I., Hoglund K., Lilliehook I., Oyama M.A., Tidholm A., Tvedten H., Haggstrom J. Serum serotonin concentration is associated with severity of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine 2013, 27:1105-1112.
32. Lobetti R.G., Milner R., Lane E. Chronic idiopathic pulmonary fibrosis in five dogs. Journal of the American Animal Hospital Association 2001, 37:119-127.
33. Locati M., Bonecchi R., Corsi M.M. Chemokines and their receptors. American Journal of Clinical Pathology 2005, 123:S82-S85.
34. Mangklabruks T., Surachetpong S.D. Plasma and platelet serotonin concentrations in healthy dogs and dogs with myxomatous mitral valve disease. Journal of Veterinary Cardiology 2014, 16:155-162.
35. Martina S., Martina V., Monika M., Jan P., Libor K., Ilja S. Angiostatic versus angiogenic chemokines in IPF and EAA. Respiratory Medicine 2009, 103:1651-1656.
36. Moore B.B. Following the path of CCL2 from prostaglandins to periostin in lung fibrosis. American Journal of Respiratory Cell and Molecular Biology 2014, 50:848-852.
37. Moore B.B., Kolodsick J.E., Thannickal V.J., Cooke K., Moore T.A., Hogaboam C., Wilke C.A., Toews G.B. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. The American Journal of Pathology 2005, 166:675-684.
38. Nestor D.D., Holan K.M., Johnson C.A., Schall W., Kaneene J.B. Serum alkaline phosphatase activity in Scottish Terriers versus dogs of other breeds. Journal of the American Veterinary Medical Association 2006, 228:222-224.
39. Oyama M.A., Levy R.J. Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease. Journal of Veterinary Internal Medicine 2010, 24:27-36.
40. Phillips R.J., Burdick M.D., Hong K., Lutz M.A., Murray L.A., Xue Y.Y., Belperio J.A., Keane M.P., Strieter R.M. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. The Journal of Clinical Investigation 2004, 114:438-446.
41. Raghu G., Collard H.R., Egan J.J., Martinez F.J., Behr J., Brown K.K., Colby T.V., Cordier J.F., Flaherty K.R., Lasky J.A., Lynch D.A., Ryu J.H., Swigris J.J., Wells A.U., Ancochea J., Bouros D., Carvalho C., Costabel U., Ebina M., Hansell D.M., Johkoh T., Kim D.S., King T.E., Kondoh Y., Myers J., Muller N.L., Nicholson A.G., Richeldi L., Selman M., Dudden R.F., Griss B.S., Protzko S.L., Schunemann H.J. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. American Journal of Respiratory and Critical Care Medicine 2011, 183:788-824.
42. Richards T.J., Kaminski N., Baribaud F., Flavin S., Brodmerkel C., Horowitz D., Li K., Choi J., Vuga L.J., Lindell K.O., Klesen M., Zhang Y., Gibson K.F. Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine 2012, 185:67-76.
43. Rosenkilde M.M., Schwartz T.W. The chemokine system - a major regulator of angiogenesis in health and disease. Acta Pathologica, Microbiologica et Immunologica Scandinavica 2004, 112:481-495.
44. Shinoda H., Tasaka S., Fujishima S., Yamasawa W., Miyamoto K., Nakano Y., Kamata H., Hasegawa N., Ishizaka A. Increased CC chemokine level in bronchoalveolar lavage fluids is predictive of a poor outcome in idiopathic pulmonary fibrosis. Respiration 2009, 78:285-292.
45. Skurikhin E.G., Andreeva T.V., Khmelevskaya E.S., Ermolaeva L.A., Pershina O.V., Krupin V.A., Ermakova N.N., Reztsova A.M., Stepanova I.E., Gol'dberg V.E., Dygai A.M. Effect of antiserotonin drug on the development of lung fibrosis and blood system reactions after intratracheal administration of bleomycin. Bulletin of Experimental Biology and Medicine 2012, 152:519-523.
46. Strieter R.M., Belperio J.A., Keane M.P. CXC chemokines in angiogenesis related to pulmonary fibrosis. Chest 2002, 122:298S-301S.
47. Suga M., Iyonaga K., Ichiyasu H., Saita N., Yamasaki H., Ando M. Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases. The European Respiratory Journal 1999, 14:376-382.
48. Syrjä P., Heikkilä H.P., Lilja-Maula L., Krafft E., Clercx C., Day M.J., Ronty M., Myllarniemi M., Rajamäki M.M. The histopathology of idiopathic pulmonary fibrosis in west highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man. Journal of Comparative Pathology 2013, 149:303-313.
49. Totani Y., Saitoh Y., Sakakibara H., Miyamori I., Ishizaki T. Clinical characterization of interleukin-8 in patients with idiopathic pulmonary fibrosis. The Journal of the Japanese Respiratory Society 2002, 40:869-874.
50. Vasakova M., Sterclova M., Kolesar L., Slavcev A., Pohunek P., Sulc J., Skibova J., Striz I. Bronchoalveolar lavage fluid cellular characteristics, functional parameters and cytokine and chemokine levels in interstitial lung diseases. Scandinavian Journal of Immunology 2009, 69:268-274.
51. Woodcock H.V., Molyneaux P.L., Maher T.M. Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib. Journal of Drug Design Development and Therapy 2013, 7:503-510.
52. Ziegenhagen M.W., Schrum S., Zissel G., Zipfel P.F., Schlaak M., Muller-Quernheim J. Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis. Journal of Investigative Medicine 1998, 46:223-231.
53. Ziegenhagen M.W., Zabel P., Zissel G., Schlaak M., Muller-Quernheim J. Serum level of interleukin 8 is increased in idiopathic pulmonary fibrosis and indicates disease activity. American Journal of Respiratory and Critical Care Medicine 1998, 157:762-768.
54. Zimmerman K.L., Panciera D.L., Panciera R.J., Oliver J.W., Hoffmann W.E., Binder E.M., Randall D.C., Kinnarney J.H. Hyperphosphatasemia and concurrent adrenal gland dysfunction in apparently healthy Scottish terriers. Journal of the American Veterinary Medical Association 2010, 237:178-186.