miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts

Carcinogenesis

Volumn 36, Issue 8, 2015, Pages 894-903

  Tanaka, Koji ^a   Miyata, Hiroshi ^a   Sugimura, Keijiro ^a   Fukuda, Shuichi ^a   Kanemura, Takashi ^a   Yamashita, Kotaro ^a   Miyazaki, Yasuhiro ^a   Takahashi, Tsuyoshi ^a   Kurokawa, Yukinori ^a   Yamasaki, Makoto ^a   Wada, Hisashi ^a   Nakajima, Kiyokazu ^a   Takiguchi, Shuji ^a   Mori, Masaki ^a   Doki, Yuichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CISPLATIN; MICRORNA; MICRORNA 107; MICRORNA 16; MICRORNA 19B; MICRORNA 223; MICRORNA 25; MICRORNA 27; MICRORNA 27A; MICRORNA 27B; MICRORNA 373; MICRORNA 378B; MICRORNA 411; MICRORNA 449C; MICRORNA 451; MICRORNA 490 3P; MICRORNA 519B 3P; MICRORNA 520E; MICRORNA 598; MICRORNA 648; MICRORNA 875 3P; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACTA2 PROTEIN, HUMAN; ACTIN; MIRN27 MICRORNA, HUMAN;

APOPTOSIS; ARTICLE; BLAST TRANSFORMATION; CANCER ASSOCIATED FIBROBLAST; CANCER CHEMOTHERAPY; CAUSE SPECIFIC SURVIVAL; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; DRUG RESISTANCE; ENDOSCOPY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CANCER; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR MICROENVIRONMENT; UPREGULATION; AGED; BLOOD; CELL CULTURE; CELL TRANSFORMATION; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; REFERENCE VALUE; VERY ELDERLY;

ACTINS; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CISPLATIN; DRUG RESISTANCE, NEOPLASM; ESOPHAGEAL NEOPLASMS; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; MIDDLE AGED; REFERENCE VALUES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84938691134     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv067     Document Type: Article

References (54)

1. Miyata, H. et al. (2011) Survival factors in patients with recurrence after curative resection of esophageal squamous cell carcinomas. Ann. Surg. Oncol., 18, 3353-3361.
2. Miyata, H. et al. (2009) Tumor budding in tumor invasive front predicts prognosis and survival of patients with esophageal squamous cell carcinomas receiving neoadjuvant chemotherapy. Cancer, 115, 3324-3334.
3. Hamano, R. et al. (2011) Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin. Cancer Res., 17, 3029-3038.
4. Imanaka, Y. et al. (2011) MicroRNA-141 confers resistance to cisplatininduced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. J. Hum. Genet., 56, 270-276.
5. Hummel, R. et al. (2011) Mir-148a improves response to chemotherapy in sensitive and resistant oesophageal adenocarcinoma and squamous cell carcinoma cells. J. Gastrointest. Surg., 15, 429-438.
6. Zhang, H. et al. (2010) Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma. Dig. Dis. Sci., 55, 2545-2551.
7. Sugimura, K. et al. (2012) Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma. Clin. Cancer Res., 18, 5144-5153.
8. Arroyo, J.D. et al. (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl Acad. Sci. USA, 108, 5003-5008.
9. Vickers, K.C. et al. (2011) MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell Biol., 13, 423-433.
10. Mitchell, P.S. et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA, 105, 10513-10518.
11. Hasselmann, D.O. et al. (2001) Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin. Chem., 47, 1488-1489.
12. Kosaka, N. et al. (2010) Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem., 285, 17442-17452.
13. Jung, E.J. et al. (2012) Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. Cancer, 118, 2603-2614.
14. Zhang, H.L. et al. (2011) Serum miRNA-21: elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy. Prostate, 71, 326-331.
15. Li, Y. et al. (2014) Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. Biomed Res. Int., 2014, 498491.
16. Wu, K.C. et al. (2012) Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol. Appl. Pharmacol., 262, 321-329.
17. Kadera, B.E. et al. (2013) MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. PLoS One, 8, e71978.
18. Kalluri, R. et al. (2006) Fibroblasts in cancer. Nat. Rev. Cancer, 6, 392-401.
19. Yano, M. et al. (2006) Preoperative chemotherapy for clinically nodepositive patients with squamous cell carcinoma of the esophagus. Dis. Esophagus, 19, 158-163.
20. Yamasaki, M. et al. (2011) Multicenter phase I/II study of docetaxel, cisplatin and fluorouracil combination chemotherapy in patients with advanced or recurrent squamous cell carcinoma of the esophagus. Oncology, 80, 307-313.
21. Miller, A.B. et al. (1981) Reporting results of cancer treatment. Cancer, 47, 207-214.
22. Herrera, M., et al. (2013) Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res., 19, 5914-5926.
23. Duyverman, A.M. et al. (2012) Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nat. Protoc., 7, 756-762.
24. Jörres, A. et al. (1996) Establishment and functional characterization of human peritoneal fibroblasts in culture: regulation of interleukin-6 production by proinflammatory cytokines. J. Am. Soc. Nephrol., 7, 2192-2201.
25. Cortez, M.A. et al. (2009) MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin. Biol. Ther., 9, 703-711.
26. Cheng, H. et al. (2011) Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One, 6, e17745.
27. Schmittgen, T.D. et al. (2004) A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res., 32, e43.
28. Venturini, M. et al. (1997) In Saccharomyces cerevisiae a short amino acid sequence facilitates excretion in the growth medium of periplasmic proteins. Mol. Microbiol., 23, 997-1007.
29. Martinez-Outschoorn, U.E. et al. (2010) Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle, 9, 3515-3533.
30. Mitra, A.K. et al. (2012) MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov., 2, 1100-1108.
31. Rosenthal, E. et al. (2004) Elevated expression of TGF-beta1 in head and neck cancer-associated fibroblasts. Mol. Carcinog., 40, 116-121.
32. San Francisco, I.F. et al. (2004) Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinomaassociated fibroblasts from normal prostate fibroblasts. Int. J. Cancer, 112, 213-218.
33. Fingas, C.D. et al. (2011) Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology, 54, 2076-2088.
34. Tyan, S.W. et al. (2011) Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One, 6, e15313.
35. Erez, N. et al. (2013) Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem. Biophys. Res. Commun., 437, 397-402.
36. Guttilla, I.K. et al. (2009) Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J. Biol. Chem., 284, 23204-23216.
37. Acunzo, M. et al. (2013) Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. Proc. Natl Acad. Sci. USA, 110, 8573-8578.
38. Li, Z. et al. (2010) MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells. Gynecol. Oncol., 119, 125-130.
39. Zhao, X. et al. (2011) Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. J. Exp. Clin. Cancer Res., 30, 55.
40. Micke, P. et al. (2004) Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer, 45 (suppl. 2), S163-S175.
41. Aprelikova, O. et al. (2010) The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts. Cell Cycle, 9, 4387-4398.
42. Xu, Y. et al. (2008) TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells. Br. J. Haematol., 142, 192-201.
43. Tabe, Y. et al. (2013) TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment. PLoS One, 8, e62785.
44. Yu, Y. et al. (2010) Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells. Mol. Cancer Res., 8, 1633-1642.
45. Al-Azayzih, A. et al. (2012) TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases. Biochem. Biophys. Res. Commun., 427, 165-170.
46. Ha Thi, H.T. et al. (2013) Transcriptional and post-translational regulation of Bim is essential for TGF-β and TNF-α-induced apoptosis of gastric cancer cell. Biochim. Biophys. Acta, 1830, 3584-3592.
47. Shin, I. et al. (2001) Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol. Biol. Cell, 12, 3328-3339.
48. Huang, Y. et al. (2000) Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities. J. Biol. Chem., 275, 18234-18242.
49. Cheng, J.C. et al. (2012) TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in lowgrade serous ovarian carcinoma cells. PLoS One, 7, e42436.
50. Weber, J.A. et al. (2010) The microRNA spectrum in 12 body fluids. Clin. Chem., 56, 1733-1741.
51. Hunter, M.P. et al. (2008) Detection of microRNA expression in human peripheral blood microvesicles. PLoS One, 3, e3694.
52. Wang, H. et al. (2014) Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed Res. Int., 2014, 864894.
53. Komatsu, S. et al. (2014) Circulating miR-18a: a sensitive cancer screening biomarker in human cancer. In Vivo, 28, 293-297.
54. Turchinovich, A. et al. (2013) Circulating miRNAs: cell-cell communication function? Front. Genet., 4, 119.