Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson's disease: A pilot study

International Journal of Neuroscience

Volumn 125, Issue 7, 2015, Pages 526-530

  Dragan, Elizabeth M ^a   Chen, Zhongxue ^b   Ondo, William G ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

iron; neurodegeneration; Parkinson's disease; prognosis; Restless legs syndrome; Willis Ekbom disease

Indexed keywords

ENTACAPONE; LEVODOPA; PERGOLIDE; PRAMIPEXOLE; ROPINIROLE; TOLCAPONE; ANTIPARKINSON AGENT;

ADULT; ARTICLE; BRADYKINESIA; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSKINESIA; FAMILY HISTORY; FEMALE; FOLLOW UP; HUMAN; MALE; MIDDLE AGED; MOTOR DYSFUNCTION; ONSET AGE; PARKINSON DISEASE; PHENOTYPE; PILOT STUDY; RESTLESS LEGS SYNDROME; RISK FACTOR; RISK REDUCTION; TREMOR; AGE; AGED; COMPLICATION; DISEASE COURSE; DYSKINESIAS; LONGITUDINAL STUDY; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

AGE FACTORS; AGED; ANTIPARKINSON AGENTS; DISEASE PROGRESSION; DYSKINESIAS; FEMALE; HUMANS; LEVODOPA; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PARKINSON DISEASE; PILOT PROJECTS; RESTLESS LEGS SYNDROME; SEVERITY OF ILLNESS INDEX;

EID: 84938680957     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2014.987771     Document Type: Article

References (24)

1. Peralta CM, Frauscher B, Seppi K, et al. Restless legs syndrome in Parkinson's disease. Mov Disord 2009; 24 (14): 2076-80.
2. Gomez-Esteban JC, Zarranz JJ, Tijero B, et al. Restless legs syndrome in Parkinson's disease. Mov Disord 2007; 22 (13): 1912-6.
3. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002; 59 (3): 421-4.
4. Tan EK, Lum SY, Wong MC. Restless legs syndrome in Parkinson's disease. J Neurol Sci 2002; 196 (1-2): 33-6.
5. Kumar S, Bhatia M, Behari M. Sleep disorders in Parkinson's disease. Mov Disord 2002; 17 (4): 775-81.
6. Angelini M, Negrotti A, Marchesi E, et al. A study of the prevalence of restless legs syndrome in previously untreated Parkinson's disease patients: absence of co-morbid association. J Neurol Sci 2011; 310 (1-2): 286-8.
7. Gjerstad M, Tysnes O, Larsen J. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 2011; 77 (22): 1941-6.
8. Gao X, Schwarzschild MA, O'Reilly E, et al. Restless legs syndrome and Parkinson's disease in men. Mov Disord 2010; 25: 2654-7.
9. Shin HY, Youn J, Yoon WT, et al. Restless legs syndrome in Korean patients with drug-naive Parkinson's disease: a nation-wide study. Parkinsonism Relat Disord. 2013; 19 (3): 355-8.
10. Walters AS, LeBrocq C, Passi V, et al. A preliminary look at the percentage of patients with restless legs syndrome who also have Parkinson disease, essential tremor or Tourette syndrome in a single practice. J Sleep Res 2003; 12 (4): 343-5.
11. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003; 61 (3): 304-9.
12. Connor JR, Wang XS, Allen RP, et al. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 2009; 132 (Pt 9): 2403-12.
13. Friedman A, Galazka-Friedman J, Koziorowski D. Iron as a cause of Parkinson disease-a myth or a well established hypothesis? Parkinsonism Relat Disord 2009; 15 Suppl 3: S212-4.
14. Martin WR, Wieler M, Gee M. Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Neurology 2008; 70 (16 Pt 2): 1411-7.
15. Oakley AE, Collingwood JF, Dobson J, et al. Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 2007; 68 (21): 1820-5.
16. Earley CJ, Barker, PB, Horska A, Allen RP. MRI-determined regional brain iron concentrations in early-and late-onset restless legs syndrome. Sleep Med 2006; 7 (5): 458-61.
17. De Rosa A, Guacci A, Peluso S, et al. A case of restless leg syndrome in a family with LRRK2 gene mutation. Int J Neurosci. 2013; 123 (4): 283-5.
18. Ben-Shachar D, Finberg JP, Youdim MB. Effect of iron chelators on dopamine D2 receptors. J Neurochem 1985; 45 (4): 999-1005.
19. Zhao H, Zhu W, Pan T, et al. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res 2007; 85 (5): 1065-76.
20. Qu S, Le W, Zhang X, et al. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol 2007; 66 (5): 383-8.
21. Scatton B, Dennis T, L'Heureux R, et al. Degeneration of Noradrenergic and serotonergic but not dopaminerigic neurons in the lumbar spinal cord of parkinsonian patients. Brain Res 1986; 380: 181-5.
22. Wang X, Wiesinger J, Beard J, et al. Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome. J Neurol Sci 2004; 220 (1-2): 59-66.
23. Ryu J, Lee M, Baik J. Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease. Park and Rel Disord 2011; 17 (3): 201-201.
24. Kwon D, Seo W, Yoon H, et al. Transcranial brain sonography in Parkinson's disease with restless legs syndrome 2010; 25 (10): 1373-8.