Resibufogenin induces G1-phase arrest through the proteasomal degradation of cyclin D1 in human malignant tumor cells

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Ichikawa, Masami ^a   Sowa, Yoshihiro ^a   Iizumi, Yosuke ^a   Aono, Yuichi ^a   Sakai, Toshiyuki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BUFOGENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEASOME; RETINOBLASTOMA PROTEIN; BUFADIENOLIDE DERIVATIVE; CARDIOTONIC AGENT; CCND1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, HUMAN; INDOLE DERIVATIVE; LIPOCORTIN 5; MALEIMIDE DERIVATIVE; PROTEASOME INHIBITOR;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HT 29 CELL LINE; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; APOPTOSIS; BIOSYNTHESIS; CELL AGING; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CHINESE MEDICINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASM; PHOSPHORYLATION; TUMOR CELL LINE;

ANURA;

ANNEXIN A5; APOPTOSIS; BUFANOLIDES; CARDIOTONIC AGENTS; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; INDOLES; MALEIMIDES; MEDICINE, CHINESE TRADITIONAL; NEOPLASMS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; RETINOBLASTOMA PROTEIN;

EID: 84938634611     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129851     Document Type: Article

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