메뉴 건너뛰기




Volumn 3, Issue 11, 2014, Pages e967142-1-e967142-7

The tumor immune microenvironment in octogenarians with stage I non-small cell lung cancer

Author keywords

forkhead box P3; non small cell lung cancer; octogenarians; old age; tumor infiltrating lymphocytes

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

EID: 84938631463     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/21624011.2014.967142     Document Type: Article
Times cited : (5)

References (44)
  • 1
    • 0037093947 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden
    • 12173348
    • B.K.Edwards, H.L.Howe, L.A.Ries, M.J.Thun, H.M.Rosenberg, R.Yancik, P.A.Wingo, A.Jemal, E.G.Feigal. Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden. Cancer 2002; 94(10):2766-92; PMID:12173348; http://dx.doi.org/10.1002/cncr.10593
    • (2002) Cancer , vol.94 , Issue.10 , pp. 2766-2792
    • Edwards, B.K.1    Howe, H.L.2    Ries, L.A.3    Thun, M.J.4    Rosenberg, H.M.5    Yancik, R.6    Wingo, P.A.7    Jemal, A.8    Feigal, E.G.9
  • 2
    • 37649004819 scopus 로고    scopus 로고
    • Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database
    • 18065729
    • T.K.Owonikoko, C.C.Ragin, C.P.Belani, A.B.Oton, W.E.Gooding, E.Taioli, S.S.Ramalingam. Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database. J clin oncol 2007; 25(35):5570-7; PMID:18065729; http://dx.doi.org/10.1200/JCO.2007.12.5435
    • (2007) J clin oncol , vol.25 , Issue.35 , pp. 5570-5577
    • Owonikoko, T.K.1    Ragin, C.C.2    Belani, C.P.3    Oton, A.B.4    Gooding, W.E.5    Taioli, E.6    Ramalingam, S.S.7
  • 3
    • 84938657358 scopus 로고    scopus 로고
    • The Older Population: 2010. The 2010 Census Briefs
    • C.A.Werner. The Older Population: 2010. The 2010 Census Briefs 2011.
    • (2011)
    • Werner, C.A.1
  • 4
    • 33846564385 scopus 로고    scopus 로고
    • Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON)
    • 17131307
    • C.A.van Iersel, H.J.de Koning, G.Draisma, W.P.Mali, E.T.Scholten, K.Nackaerts, M.Prokop, J.D.Habbema, M.Oudkerk, R.J.van Klaveren. Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON). Int J Cancer 2007; 120(4):868-74; PMID:17131307; http://dx.doi.org/10.1002/ijc.22134
    • (2007) Int J Cancer , vol.120 , Issue.4 , pp. 868-874
    • van Iersel, C.A.1    de Koning, H.J.2    Draisma, G.3    Mali, W.P.4    Scholten, E.T.5    Nackaerts, K.6    Prokop, M.7    Habbema, J.D.8    Oudkerk, M.9    van Klaveren, R.J.10
  • 7
    • 84874048519 scopus 로고    scopus 로고
    • Elderly patients with advanced NSCLC in phase III clinical trials: are the elderly excluded from practice-changing trials in advanced NSCLC
    • 23407560
    • A.G.Sacher, L.W.Le, N.B.Leighl, L.E.Coate. Elderly patients with advanced NSCLC in phase III clinical trials: are the elderly excluded from practice-changing trials in advanced NSCLC? J Thorac Oncol 2013; 8(3):366-8; PMID:23407560; http://dx.doi.org/10.1097/JTO.0b013e31827e2145
    • (2013) J Thorac Oncol , vol.8 , Issue.3 , pp. 366-368
    • Sacher, A.G.1    Le, L.W.2    Leighl, N.B.3    Coate, L.E.4
  • 8
    • 84863889174 scopus 로고    scopus 로고
    • Under-representation of older adults in cancer registration trials: known problem, little progress
    • 22547597
    • K.S.Scher, A.Hurria. Under-representation of older adults in cancer registration trials: known problem, little progress. J clin oncol 2012; 30(17):2036-8; PMID:22547597; http://dx.doi.org/10.1200/JCO.2012.41.6727
    • (2012) J clin oncol , vol.30 , Issue.17 , pp. 2036-2038
    • Scher, K.S.1    Hurria, A.2
  • 10
    • 58149100407 scopus 로고    scopus 로고
    • The ageing immune system: is it ever too old to become young again
    • 19104499
    • K.Dorshkind, E.Montecino-Rodriguez, R.A.Signer. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol 2009; 9(1):57-62; PMID:19104499; http://dx.doi.org/10.1038/nri2471
    • (2009) Nat Rev Immunol , vol.9 , Issue.1 , pp. 57-62
    • Dorshkind, K.1    Montecino-Rodriguez, E.2    Signer, R.A.3
  • 12
    • 77955040477 scopus 로고    scopus 로고
    • Immunosenescence and cancer
    • 20656212
    • G.Pawelec, E.Derhovanessian, A.Larbi. Immunosenescence and cancer. Crit Rev Oncol Hematol 2010; 75(2):165-72; PMID:20656212; http://dx.doi.org/10.1016/j.critrevonc.2010.06.012
    • (2010) Crit Rev Oncol Hematol , vol.75 , Issue.2 , pp. 165-172
    • Pawelec, G.1    Derhovanessian, E.2    Larbi, A.3
  • 13
    • 63149184826 scopus 로고    scopus 로고
    • OX40-enhanced tumor rejection and effector T cell differentiation decreases with age
    • 19155495
    • C.E.Ruby, A.D.Weinberg. OX40-enhanced tumor rejection and effector T cell differentiation decreases with age. J Immunol 2009; 182(3):1481-9; PMID:19155495; http://dx.doi.org/10.4049/jimmunol.182.3.1481
    • (2009) J Immunol , vol.182 , Issue.3 , pp. 1481-1489
    • Ruby, C.E.1    Weinberg, A.D.2
  • 14
    • 0034066895 scopus 로고    scopus 로고
    • Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice
    • 10819579
    • M.Provinciali, K.Argentati, A.Tibaldi. Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice. Gene Ther 2000; 7(7):624-32; PMID:10819579; http://dx.doi.org/10.1038/sj.gt.3301131
    • (2000) Gene Ther , vol.7 , Issue.7 , pp. 624-632
    • Provinciali, M.1    Argentati, K.2    Tibaldi, A.3
  • 16
    • 79952093380 scopus 로고    scopus 로고
    • Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
    • 21245428
    • B.Mlecnik, M.Tosolini, A.Kirilovsky, A.Kirilovsky, B.Mlecnik, C.Lagorce-Pagès, M.Tosolini, M.Camus, A.Berger, P.Wind, Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol 2011; 29(6):610-8; PMID:21245428; http://dx.doi.org/10.1200/JCO.2010.30.5425
    • (2011) J Clin Oncol , vol.29 , Issue.6 , pp. 610-618
    • Mlecnik, B.1    Tosolini, M.2    Kirilovsky, A.3    Kirilovsky, A.4    Mlecnik, B.5    Lagorce-Pagès, C.6    Tosolini, M.7    Camus, M.8    Berger, A.9    Wind, P.10
  • 20
    • 84874792010 scopus 로고    scopus 로고
    • Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor beta2 (IL-12Rbeta2), IL-7R, and stromal FoxP3CD3 ratio are independent predictors of recurrence
    • 23269987
    • K.Suzuki, K.Kadota, C.S.Sima, J.Nitadori, V.W.Rusch, W.D.Travis, M.Sadelain, P.S.Adusumilli, Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor beta2 (IL-12Rbeta2), IL-7R, and stromal FoxP3CD3 ratio are independent predictors of recurrence. J Clin Oncol 2013; 31(4):490-8; PMID:23269987; http://dx.doi.org/10.1200/JCO.2012.45.2052
    • (2013) J Clin Oncol , vol.31 , Issue.4 , pp. 490-498
    • Suzuki, K.1    Kadota, K.2    Sima, C.S.3    Nitadori, J.4    Rusch, V.W.5    Travis, W.D.6    Sadelain, M.7    Adusumilli, P.S.8
  • 21
    • 82355175864 scopus 로고    scopus 로고
    • Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma
    • 21913025
    • A.J.Bograd, K.Suzuki, E.Vertes, C.Colovos, E.A.Morales, M.Sadelain, P.S.Adusumilli. Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma. Cancer Immunol Immunother 2011; 60(11):1509-27; PMID:21913025; http://dx.doi.org/10.1007/s00262-011-1103-6
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.11 , pp. 1509-1527
    • Bograd, A.J.1    Suzuki, K.2    Vertes, E.3    Colovos, C.4    Morales, E.A.5    Sadelain, M.6    Adusumilli, P.S.7
  • 23
    • 82355182060 scopus 로고    scopus 로고
    • Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients
    • 21769693
    • K.Suzuki, K.Kadota, C.S.Sima, M.Sadelain, V.W.Rusch, W.D.Travis, P.S.Adusumilli, Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients. Cancer Immunol Immunother 2011; 60(12):1721-8; PMID:21769693; http://dx.doi.org/10.1007/s00262-011-1073-8
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.12 , pp. 1721-1728
    • Suzuki, K.1    Kadota, K.2    Sima, C.S.3    Sadelain, M.4    Rusch, V.W.5    Travis, W.D.6    Adusumilli, P.S.7
  • 25
    • 0347506020 scopus 로고    scopus 로고
    • CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers
    • 14611679
    • O.Wakabayashi, K.Yamazaki, S.Oizumi, F.Hommura, I.Kinoshita, S.Ogura, H.Dosaka-Akita, M.Nishimura. CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers. Cancer Sci 2003; 94(11):1003-9; PMID:14611679; http://dx.doi.org/10.1111/j.1349-7006.2003.tb01392.x
    • (2003) Cancer Sci , vol.94 , Issue.11 , pp. 1003-1009
    • Wakabayashi, O.1    Yamazaki, K.2    Oizumi, S.3    Hommura, F.4    Kinoshita, I.5    Ogura, S.6    Dosaka-Akita, H.7    Nishimura, M.8
  • 26
    • 77951877847 scopus 로고    scopus 로고
    • Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer
    • 20234320
    • K.Shimizu, M.Nakata, Y.Hirami, T.Yukawa, A.Maeda, K.Tanemoto. Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol 2010; 5(5):585-90; PMID:20234320
    • (2010) J Thorac Oncol , vol.5 , Issue.5 , pp. 585-590
    • Shimizu, K.1    Nakata, M.2    Hirami, Y.3    Yukawa, T.4    Maeda, A.5    Tanemoto, K.6
  • 27
    • 70349423483 scopus 로고    scopus 로고
    • Intraepithelial effector (CD3+)regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    • 19577568
    • F.A.Sinicrope, R.L.Rego, S.M.Ansell, K.L.Knutson, N.R.Foster, D.J.Sargent. Intraepithelial effector (CD3+)regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009; 137(4):1270-9; PMID:19577568; http://dx.doi.org/10.1053/j.gastro.2009.06.053
    • (2009) Gastroenterology , vol.137 , Issue.4 , pp. 1270-1279
    • Sinicrope, F.A.1    Rego, R.L.2    Ansell, S.M.3    Knutson, K.L.4    Foster, N.R.5    Sargent, D.J.6
  • 28
    • 33244473948 scopus 로고    scopus 로고
    • Undertreatment of elderly patients with non-small-cell lung cancer
    • 16354310
    • R.Ng, R.de Boer, M.D.Green. Undertreatment of elderly patients with non-small-cell lung cancer. Clin Lung Cancer 2005; 7(3):168-74; PMID:16354310; http://dx.doi.org/10.3816/CLC.2005.n.031
    • (2005) Clin Lung Cancer , vol.7 , Issue.3 , pp. 168-174
    • Ng, R.1    de Boer, R.2    Green, M.D.3
  • 29
    • 24944445043 scopus 로고    scopus 로고
    • Advanced age is not correlated with either short-term or long-term postoperative results in lung cancer patients in good clinical condition
    • 16162758
    • S.Sawada, E.Komori, N.Nogami, A.Bessho, Y.Segawa, T.Shinkai, M.Nakata, M.Yamashita. Advanced age is not correlated with either short-term or long-term postoperative results in lung cancer patients in good clinical condition. Chest 2005; 128(3):1557-63; PMID:16162758; http://dx.doi.org/10.1378/chest.128.3.1557
    • (2005) Chest , vol.128 , Issue.3 , pp. 1557-1563
    • Sawada, S.1    Komori, E.2    Nogami, N.3    Bessho, A.4    Segawa, Y.5    Shinkai, T.6    Nakata, M.7    Yamashita, M.8
  • 30
    • 77953173038 scopus 로고    scopus 로고
    • Lung cancer in octogenarians
    • 20521358
    • E.M.Blanchard, K.Arnaoutakis, P.J.Hesketh. Lung cancer in octogenarians. J Thorac Oncol 2010; 5(6):909-16; PMID:20521358; http://dx.doi.org/10.1097/JTO.0b013e3181d89b48
    • (2010) J Thorac Oncol , vol.5 , Issue.6 , pp. 909-916
    • Blanchard, E.M.1    Arnaoutakis, K.2    Hesketh, P.J.3
  • 31
    • 70449580653 scopus 로고    scopus 로고
    • Risk of recurrence of resected stage I non-small cell lung cancer in elderly patients as compared with younger patients
    • 19692932
    • B.Goodgame, A.Viswanathan, J.Zoole, F.Gao, C.R.Miller, J.Subramanian, B.F.Meyers, A.G.Patterson, R.Govindan. Risk of recurrence of resected stage I non-small cell lung cancer in elderly patients as compared with younger patients. J Thorac Oncol 2009; 4(11):1370-4; PMID:19692932; http://dx.doi.org/10.1097/JTO.0b013e3181b6bc1b
    • (2009) J Thorac Oncol , vol.4 , Issue.11 , pp. 1370-1374
    • Goodgame, B.1    Viswanathan, A.2    Zoole, J.3    Gao, F.4    Miller, C.R.5    Subramanian, J.6    Meyers, B.F.7    Patterson, A.G.8    Govindan, R.9
  • 32
    • 0033020457 scopus 로고    scopus 로고
    • Results of surgical treatment of lung cancer in octogenarians
    • 10217616
    • T.Hanagiri, H.Muranaka, M.Hashimoto, A.Nagashima, K.Yasumoto. Results of surgical treatment of lung cancer in octogenarians. Lung Cancer 1999; 23(2):129-33; PMID:10217616; http://dx.doi.org/10.1016/S0169-5002(99)00006-9
    • (1999) Lung Cancer , vol.23 , Issue.2 , pp. 129-133
    • Hanagiri, T.1    Muranaka, H.2    Hashimoto, M.3    Nagashima, A.4    Yasumoto, K.5
  • 33
    • 2642573558 scopus 로고    scopus 로고
    • Participation in cancer clinical trials: race-, sex-, and age-based disparities
    • 15187053
    • V.H.Murthy, H.M.Krumholz, C.P.Gross. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 2004; 291(22):2720-6; PMID:15187053; http://dx.doi.org/10.1001/jama.291.22.2720
    • (2004) JAMA , vol.291 , Issue.22 , pp. 2720-2726
    • Murthy, V.H.1    Krumholz, H.M.2    Gross, C.P.3
  • 34
    • 33645346222 scopus 로고    scopus 로고
    • Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials
    • 16640737
    • R.R.Jennens, G.G.Giles, R.M.Fox. Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials. Intern Med J 2006; 36(4):216-20; PMID:16640737; http://dx.doi.org/10.1111/j.1445-5994.2006.01033.x
    • (2006) Intern Med J , vol.36 , Issue.4 , pp. 216-220
    • Jennens, R.R.1    Giles, G.G.2    Fox, R.M.3
  • 35
    • 84876942195 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic T cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer
    • 23580578
    • J.G.Aerts, J.P.Hegmans. Tumor-specific cytotoxic T cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer. Cancer Res 2013; 73(8):2381-8; PMID:23580578; http://dx.doi.org/10.1158/0008-5472.CAN-12-3932
    • (2013) Cancer Res , vol.73 , Issue.8 , pp. 2381-2388
    • Aerts, J.G.1    Hegmans, J.P.2
  • 36
    • 32644466544 scopus 로고    scopus 로고
    • Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer
    • 16219934
    • T.J.Welsh, R.H.Green, D.Richardson, Waller DA, K.J.O'Byrne, P.Bradding. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 2005; 23(35):8959-67; PMID:16219934; http://dx.doi.org/10.1200/JCO.2005.01.4910
    • (2005) J Clin Oncol , vol.23 , Issue.35 , pp. 8959-8967
    • Welsh, T.J.1    Green, R.H.2    Richardson, D.3    Waller, D.A.4    O'Byrne, K.J.5    Bradding, P.6
  • 37
    • 77952937103 scopus 로고    scopus 로고
    • The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time
    • 20338029
    • J.Ma, L.Liu, G.Che, N.Yu, F.Dai, Z.You. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC cancer 2010; 10:112; PMID:20338029; http://dx.doi.org/10.1186/1471-2407-10-112
    • (2010) BMC cancer , vol.10 , pp. 112
    • Ma, J.1    Liu, L.2    Che, G.3    Yu, N.4    Dai, F.5    You, Z.6
  • 38
    • 84867583274 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer
    • 22456757
    • H.Liu, T.Zhang, J.Ye, H.Li, J.Huang, X.Li, B.Wu, X.Huang, J.Hou. Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer. Cancer Immunol Immunother 2012; 61(10):1849-56; PMID:22456757; http://dx.doi.org/10.1007/s00262-012-1231-7
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.10 , pp. 1849-1856
    • Liu, H.1    Zhang, T.2    Ye, J.3    Li, H.4    Huang, J.5    Li, X.6    Wu, B.7    Huang, X.8    Hou, J.9
  • 42
    • 84859828691 scopus 로고    scopus 로고
    • Competing risk analyses: how are they different and why should you care
    • 22427347
    • R.Chappell. Competing risk analyses: how are they different and why should you care? Clin Cancer Res 2012; 18(8):2127-9; PMID:22427347; http://dx.doi.org/10.1158/1078-0432.CCR-12-0455
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2127-2129
    • Chappell, R.1
  • 43
    • 84859842971 scopus 로고    scopus 로고
    • The use and interpretation of competing risks regression models
    • 22282466
    • J.J.Dignam, Q.Zhang, M.Kocherginsky. The use and interpretation of competing risks regression models. Clin Cancer Res 2012; 18(8):2301-8; PMID:22282466; http://dx.doi.org/10.1158/1078-0432.CCR-11-2097
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2301-2308
    • Dignam, J.J.1    Zhang, Q.2    Kocherginsky, M.3
  • 44
    • 0000120995 scopus 로고
    • A class of K-sample tests for comparing the cumulative incidence of a competing risk
    • R.J.Gray. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988; 16(3):1141-54; http://dx.doi.org/10.1214/aos/1176350951
    • (1988) Ann Stat , vol.16 , Issue.3 , pp. 1141-1154
    • Gray, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.