Pregabalin and pain after total knee arthroplasty: A double-blind, randomized, placebo-controlled, multidose trial

British Journal of Anaesthesia

Volumn 115, Issue 2, 2015, Pages 285-293

  YaDeau, J T ^a   Lin, Y ^a   Mayman, D J ^a   Goytizolo, E A ^a   Alexiades, M M ^a   Padgett, D E ^a   Kahn, R L ^a   Jules Elysee, K M ^a   Ranawat, A S ^a   Bhagat, D D ^a   Fields, K G ^a   Goon, A K ^a   Curren, J ^a   Westrich, G H ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

analgesia; anticonvulsants; arthroplasty; knee; pain management; perioperative care; replacement

Indexed keywords

ADRENALIN; BUPIVACAINE; DEXAMETHASONE; HYDROMORPHONE; MELOXICAM; OXYCODONE; PARACETAMOL; PLACEBO; PREGABALIN; PROPOFOL; 4 AMINOBUTYRIC ACID; ANALGESIC AGENT;

ADULT; AGED; ARTICLE; BEDTIME DOSAGE; CHRONIC PAIN; CONFUSION; CONTROLLED STUDY; DOSE RESPONSE; DROWSINESS; DRUG USE; DRUG WITHDRAWAL; EPIDURAL ANESTHESIA; FEMALE; FEMORAL NERVE; HUMAN; KNEE FUNCTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; NERVE BLOCK; NEUROPATHIC PAIN; PAIN ASSESSMENT; PATIENT COMPLIANCE; PATIENT MOBILITY; PATIENT SATISFACTION; POSTOPERATIVE ANALGESIA; POSTOPERATIVE NAUSEA; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REST; SEDATION; SURGICAL PATIENT; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME; TREATMENT WITHDRAWAL; ANALOGS AND DERIVATIVES; DOUBLE BLIND PROCEDURE; KNEE ARTHROPLASTY; MIDDLE AGED; PAIN, POSTOPERATIVE;

ADULT; AGED; ANALGESICS; ARTHROPLASTY, REPLACEMENT, KNEE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; PREGABALIN; PROSPECTIVE STUDIES;

EID: 84938592977     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aev217     Document Type: Article

References (31)

1. Schmidt PC, Ruchelli G, Mackey SC, Carroll IR. Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain. Anesthesiology 2013; 119: 1215-21
2. Buvanendran A, Kroin JS, Della Valle CJ, Kari M, Moric M, Tuman KJ. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg 2010; 110: 199-207
3. Chaparro LE, Clarke H, Valdes PA, Mira M, Duque L, Mitsakakis N. Adding pregabalin to a multimodal analgesic regimen does not reduce pain scores following cosmetic surgery: a randomized trial. J Anesth 2012; 26: 829-35
4. YaDeau JT, Paroli L, Kahn RL, et al. Addition of pregabalin to multimodal analgesic therapy following ankle surgery: a randomized double-blind, placebo-controlled trial. Reg Anesth Pain Med 2012; 37: 302-7
5. Engelman E, Cateloy F. Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta Anaesthesiol Scand 2011; 55: 927-43
6. Clarke H, Bonin RP, Orser BA, Englesakis M,Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesth Analg 2012; 115: 428-42
7. YaDeau JT, Cahill JB, Zawadsky MW, et al. The effects of femoral nerve blockade in conjunction with epidural analgesia after total knee arthroplasty. Anesth Analg 2005; 101: 891-5
8. Brander VA, Stulberg SD, Adams AD, et al. Predicting total knee replacement pain: a prospective, observational study. Clin Orthop Relat Res 2003; 416: 27-36
9. Buvanendran A, Kroin JS, Tuman KJ, et al. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. JAMA 2003; 290: 2411-8
10. Liu SS, Buvanendran A, Rathmell JP, et al. A cross-sectional survey on prevalence and risk factors for persistent postsurgical pain 1 year after total hip and knee replacement. Reg Anesth Pain Med 2012; 37: 415-22
11. YaDeau JT, Liu SS, Rade MC, Marcello D, Liguori GA. Performance characteristics and validation of the Opioid-Related Symptom Distress Scale for evaluation of analgesic side effects after orthopedic surgery. Anesth Analg 2011; 113: 369-77
12. Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 1990; 113: 941-8
13. Inouye SK. The Confusion Assessment Method (CAM): Training Manual and Coding Guide. New Haven: Yale University School of Medicine, 2003
14. Rade MC, YaDeau JT, Ford C, Reid MC. Postoperative delirium in elderly patients after elective hip or knee arthroplasty performed under regional anesthesia. HSS J 2011; 7: 151-6
15. Apfelbaum JL, Gan TJ, Zhao S, Hanna DB, Chen C. Reliability and validity of the perioperative opioid-related symptom distress scale. Anesth Analg 2004; 99: 699-709
16. Bennett MI, Smith BH, Torrance N, Potter J. The S-LANSS scores for identifying pain of predominantly neuropathic origin: validation for use in clinical and postal research. J Pain 2005; 6: 149-58
17. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)-a metadatadriven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377-81
18. Ma Y, Mazumdar M, Memtsoudis SG. Beyond repeated-measures analysis of variance: advanced statistical methods for the analysis of longitudinal data in anesthesia research. Reg Anesth Pain Med 2012; 37: 99-105
19. Zeger SL, Liang KY, Albert PS. Models for longitudinal data: a generalized estimating equation approach. Biometrics 1988; 44: 1049-60
20. Bang H, Flaherty SP, Kolahi J, Park J. Blinding assessment in clinical trials: a review of statistical methods and a proposal of blinding assessment protocol. Clin Res Regul Aff 2010; 27: 42-51
21. Cnaan A, Zhao H, Silber JH. Measuring compliance and its effect on analyses in longitudinal clinical trials. Proceedings of the ENAR Spring Meeting-Biometric Section to Include ENAR & WNAR. Washington, DC, USA: 2002; 591-95
22. Vander Stichele R. Measurement of patient compliance and the interpretation of randomized clinical trials. Eur J Clin Pharmacol 1991; 41: 27-35
23. Singer AJ, Thode HC Jr. Determination of the minimal clinically significant difference on a patient visual analog satisfaction scale. Acad Emerg Med 1998; 5: 1007-11
24. Paul JE, Nantha-Aree M, Buckley N, et al. Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial. Can J Anaesth 2013; 60: 423-31
25. Wang H, Boctor B, Verner J. The effect of single-injection femoral nerve block on rehabilitation and length of hospital stay after total knee replacement. Reg Anesth Pain Med 2002; 27: 139-44
26. Stern JM, Simes RJ. Publication bias: evidence of delayed publication in a cohort study of clinical research projects. Br Med J 1997; 315: 640-5
27. Burke SM, Shorten GD. Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. Anesth Analg 2010; 110: 1180-5
28. Pesonen A, Suojaranta-Ylinen R, Hammarén E, et al. Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. Br J Anaesth 2011; 106: 873-81
29. Gossec L, Tubach F, Dougados M, Ravaud P. Reporting of adherence to medication in recent randomized controlled trials of 6 chronic diseases: a systematic literature review. Am J Med Sci 2007; 334: 248-54
30. Moore A,Wiffen P, Kalso E. Antiepileptic drugs for neuropathic pain and fibromyalgia. JAMA 2014; 312: 182-331
31. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation 2009; 119: 3028-35