Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699)

Pharmaceutical Research

Volumn 32, Issue 1, 2015, Pages 37-46

  Durmus, Selvi ^a   Sparidans, Rolf W ^b   Van Esch, Anita ^a   Wagenaar, Els ^a   Beijnen, Jos H ^b,c   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

ABC transporters; brain accumulation; oral availability; PARP inhibitor; rucaparib

Indexed keywords

ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCG2 PROTEIN, HUMAN; ABCG2 PROTEIN, MOUSE; INDOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RUCAPARIB; TUMOR PROTEIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; BLOOD; BRAIN; CULTURE TECHNIQUE; DOG; ENZYME SPECIFICITY; FEMALE; GENETICS; HUMAN; KNOCKOUT MOUSE; MDCK CELL LINE; METABOLISM; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BRAIN; CELL CULTURE TECHNIQUES; DOGS; FEMALE; HUMANS; INDOLES; MADIN DARBY CANINE KIDNEY CELLS; MICE, KNOCKOUT; NEOPLASM PROTEINS; P-GLYCOPROTEINS; POLY(ADP-RIBOSE) POLYMERASES; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84938587076     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1442-z     Document Type: Article

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