Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia

Frontiers in Aging Neuroscience

Volumn 7, Issue JUL, 2015, Pages

  Tan, Rachel H ^a,b   Devenney, Emma ^a,b   Kiernan, Matthew C ^a,c   Halliday, Glenda M ^a,b   Hodges, John R ^a,b,d   Hornberger, Michael ^a,e  

^a NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d ARC CENTRE OF EXCELLENCE IN COGNITION AND ITS DISORDERS   (Australia)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Behavioral variant frontotemporal dementia; Cerebellum; Cognition; Neural correlates; Neuropsychiatric processes

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN FUNCTION; CEREBELLUM; CEREBELLUM VERMIS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; EMOTION; EXECUTIVE FUNCTION; FEMALE; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; GRAY MATTER; HUMAN; LANGUAGE; LANGUAGE DISABILITY; MALE; MEMORY; MENTAL DISEASE; MOTIVATION; NEUROIMAGING; VISUOSPATIAL FUNCTION; VOXEL BASED MORPHOMETRY;

EID: 84938568647     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00121     Document Type: Article

References (46)

1. Andersson, J.L. R., Jenkinson, M., and Smith, S. (2007a). Non-linear optimisation FMRIB Technial Report TR07JA1. Oxford: FMRIB Centre.
2. Bak, T.H., and Hodges, J.R. (2001). Motor neurone disease, dementia and aphasia: coincidence, co-occurrence or continuum? J. Neurol. 248, 260-270. doi: 10.1007/s004150170199.
3. Baumann, O., and Mattingley, J.B. (2012). Functional topography of primary emotion processing in the human cerebellum. Neuroimage 61, 805-811. doi: 10.1016/j.neuroimage.2012.03.044.
4. Bertoux, M., Volle, E., De Souza, L.C., Funkiewiez, A., Dubois, B., and Habert, M.O. (2014). Neural correlates of the mini-SEA (social cognition and emotional assessment) in behavioral variant frontotemporal dementia. Brain Imaging Behav. 8, 1-6. doi: 10.1007/s11682-013-9261-0.
5. Brooks, B.R., Miller, R.G., Swash, M., and Munsat, T.L. (2000). El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1, 293-299. doi: 10.1080/146608200300079536.
6. Eslinger, P.J., Moore, P., Antani, S., Anderson, C., and Grossman, M. (2012). Apathy in frontotemporal dementia: behavioral and neuroimaging correlates. Behav. Neurol. 25, 127-136. doi: 10.1155/2012/286427.
7. Frisch, S., Dukart, J., Vogt, B., Horstmann, A., Becker, G., Villringer, A., et al. (2013). Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy. PLoS ONE 8:e55251. doi: 10.1371/journal.pone.0055251.
8. Goodglass, H., K.E. (2000). Boston Naming Test, 2nd Edn. Philadelphia, PA: Lippincott Williams & Wilkins.
9. Grossman, M., McMillan, C., Moore, P., Ding, L., Glosser, G., Work, M., et al. (2004). What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration. Brain 127, 628-649. doi: 10.1093/brain/awh075.
10. Hornberger, M., Piguet, O., Kipps, C., and Hodges, J.R. (2008). Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia. Neurology 71, 1481-1488. doi: 10.1212/01.wnl.0000334299.72023.c8.
11. Hornberger, M., Wong, S., Tan, R., Irish, M., Piguet, O., Kril, J., et al. (2012). In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain 135, 3015-3025. doi: 10.1093/brain/aws239.
12. Huey, E.D., Goveia, E.N., Paviol, S., Pardini, M., Krueger, F., Zamboni, G., et al. (2009). Executive dysfunction in frontotemporal dementia and corticobasal syndrome. Neurology 72, 453-459. doi: 10.1212/01.wnl.0000341781.39164.26.
13. Irish, M., Devenney, E., Wong, S., Dobson-Stone, C., Kwok, J.B., Piguet, O., et al. (2013). Neural substrates of episodic memory dysfunction in behavioural variant frontotemporal dementia with and without C9ORF72 expansions. Neuroimage Clin. 2, 836-843. doi: 10.1016/j.nicl.2013.06.005.
14. Irish, M., Piguet, O., Hodges, J.R., and Hornberger, M. (2014). Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and Alzheimer's Disease. Hum. Brain Mapp. 35, 1422-1435. doi: 10.1002/hbm.22263.
15. Kelly, R.M., and Strick, P.L. (2003). Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J. Neurosci. 23, 8432-8444.
16. Keren-Happuch, E., Chen, S.H. A., Ho, M.H. R., and Desmond, J.E. (2014). A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI Studies. Hum. Brain Mapp. 35, 593-615. doi: 10.1002/hbm.22194.
17. Krienen, F.M., and Buckner, R.L. (2009). Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity. Cereb. Cortex 19, 2485-2497. doi: 10.1093/cercor/bhp135.
18. Kumfor, F., Irish, M., Hodges, J.R., and Piguet, O. (2013). Discrete neural correlates for the recognition of negative emotions: insights from frontotemporal dementia. PLoS ONE 8:e67457. doi: 10.1371/journal.pone.0067457.
19. Kumfor, F., Sapey-Triomphe, L.A., Leyton, C.E., Burrell, J.R., Hodges, J.R., and Piguet, O. (2014). Degradation of emotion processing ability in corticobasal syndrome and Alzheimer's disease. Brain 137, 3061-3072. doi: 10.1093/brain/awu246.
20. Lillo, P., Garcin, B., Hornberger, M., Bak, T.H., and Hodges, J.R. (2010). Neurobehavioral features in frontotemporal dementia with amyotrophic lateral sclerosis. Arch. Neurol. 67, 826-830. doi: 10.1001/archneurol.2010.146.
21. Links, K.A., Black, S.E., Graff-Guerrero, A., Wilson, A.A., Houle, S., Pollock, B.G., et al. (2013). A case of apathy due to frontotemporal dementia responsive to memantine. Neurocase 19, 256-261. doi: 10.1080/13554794.2012.667120.
22. Middleton, F.A., and Strick, P.L. (2000). Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res. Brain Res. Rev. 31, 236-250. doi: 10.1016/S0165-0173(99)00040-5.
23. Middleton, F.A., and Strick, P.L. (2001). Cerebellar projections to the prefrontal cortex of the primate. J. Neurosci. 21, 700-712.
24. Miller, L.A., Hsieh, S., Lah, S., Savage, S., Hodges, J.R., and Piguet, O. (2012). One size does not fit all: face emotion processing impairments in semantic dementia, behavioural-variant frontotemporal dementia and Alzheimer's disease are mediated by distinct cognitive deficits. Behav. Neurol. 25, 53-60. doi: 10.1155/2012/683052.
25. Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., and Hodges, J.R. (2006). The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int. J. Geriatr. Psychiatry 21, 1078-1085. doi: 10.1002/gps.1610.
26. Nichols, T.E., and Holmes, A.P. (2002). Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum. Brain Mapp. 15, 1-25. doi: 10.1002/hbm.1058.
27. O'Reilly, J.X., Beckmann, C.F., Tomassini, V., Ramnani, N., and Johansen-Berg, H. (2010). Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity. Cereb. Cortex 20, 953-965. doi: 10.1093/cercor/bhp157.
28. Pennington, C., Hodges, J.R., and Hornberger, M. (2011). Neural correlates of episodic memory in behavioral variant frontotemporal dementia. J. Alzheimers Dis. 24, 261-268. doi: 10.3233/JAD-2011-101668.
29. Rabinovici, G.D., Seeley, W.W., Kim, E.J., Gorno-Tempini, M.L., Rascovsky, K., Pagliaro, T.A., et al. (2007). Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration. Am. J. Alzheimers. Dis. Other Demen. 22, 474-488. doi: 10.1177/1533317507308779.
30. Raczka, K.A., Becker, G., Seese, A., Frisch, S., Heiner, S., Marschhauser, A., et al. (2010). Executive and behavioral deficits share common neural substrates in frontotemporal lobar degeneration - A pilot FDG-PET study. Psychiatry Res. 182, 274-280. doi: 10.1016/j.pscychresns.2010.02.009.
31. Rascovsky, K., Hodges, J.R., Knopman, D., Mendez, M.F., Kramer, J.H., Neuhaus, J., et al. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134, 2456-2477. doi: 10.1093/brain/awr179.
32. Riva, D., Annunziata, S., Contarino, V., Erbetta, A., Aquino, D., and Bulgheroni, S. (2013). Gray matter reduction in the vermis and CRUS-II is associated with social and interaction deficits in low-functioning children with autistic spectrum disorders: a VBM-DARTEL study. Cerebellum 12, 676-685. doi: 10.1007/s12311-013-0469-8.
33. Savage, S., Hsieh, S., Leslie, F., Foxe, D., Piguet, O., and Hodges, J.R. (2013). Distinguishing subtypes in primary progressive aphasia: application of the Sydney language battery. Dement. Geriatr. Cogn. Disord. 35, 208-218. doi: 10.1159/000346389.
34. Schmahmann, J.D., and Sherman, J.C. (1998). The cerebellar cognitive affective syndrome. Brain 121, 561-579. doi: 10.1093/brain/121.4.561.
35. Seeley, W.W., Crawford, R., Rascovsky, K., Kramer, J.H., Weiner, M., Miller, B.L., et al. (2008). Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Arch. Neurol. 65, 249-E241. doi: 10.1001/archneurol.2007.38.
36. Smith, S.M. (2002). Fast robust automated brain extraction. Hum. Brain Mapp. 17, 143-155. doi: 10.1002/hbm.10062.
37. Smith, S.M., and Nichols, T.E. (2009). Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 44, 83-98. doi: 10.1016/j.neuroimage.2008.03.061.
38. Stoodley, C.J., and Schmahmann, J.D. (2009). Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44, 489-501. doi: 10.1016/j.neuroimage.2008.08.039.
39. Stoodley, C.J., and Schmahmann, J.D. (2010). Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46, 831-844. doi: 10.1016/j.cortex.2009.11.008.
40. Stoodley, C.J., Valera, E.M., and Schmahmann, J.D. (2012). Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study. Neuroimage 59, 1560-1570. doi: 10.1016/j.neuroimage.2011.08.065.
41. Tan, R.H., Devenney, E., Dobson-Stone, C., Kwok, J.B., Hodges, J.R., Kiernan, M.C., et al. (2014). Cerebellar integrity in the amyotrophic lateral sclerosis - frontotemporal dementia continuum. PLoS ONE 9:e105632. doi: 10.1371/journal.pone.0105632.
42. Wedderburn, C., Wear, H., Brown, J., Mason, S.J., Barker, R.A., Hodges, J., et al. (2008). The utility of the Cambridge Behavioural Inventory in neurodegenerative disease. J. Neurol. Neurosurg. Psychiatr. 79, 500-503. doi: 10.1136/jnnp.2007.122028.
43. Woost, T.B., Dukart, J., Frisch, S., Barthel, H., Sabri, O., Mueller, K., et al. (2013). Neural correlates of the DemTect in Alzheimer's disease and frontotemporal lobar degeneration - A combined MRI and FDG-PET study. Neuroimage Clin. 2, 746-758. doi: 10.1016/j.nicl.2013.05.008.
44. Yi, D.S., Bertoux, M., Mioshi, E., Hodges, J., and Hornberger, M. (2013). Fronto-striatal atrophy correlates of neuropsychiatric dysfunction in frontotemporal dementia (FTD) and Alzheimer's disease (AD). Dement Neuropsychol. 7, 75-82.
45. Young Aw, P.D., Calder, A.J., Sprengelmeyer, R., and Ekman, P. (2002). Facial Expressions of Emotion - Stimuli and Tests (FEEST). Bury St Edmunds: Thames Valley Test Company.
46. Zhang, Y., Brady, M., and Smith, S. (2001). Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans. Med. Imaging 20, 45-57. doi: 10.1109/42.906424.