Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Zhang, Yiming ^a,c   Liu, Guodong ^a,c   Engqvist, Martin K M ^a,c   Krivoruchko, Anastasia ^a,c   Hallström, Björn M ^b   Chen, Yun ^a,c   Siewers, Verena ^a,c   Nielsen, Jens ^a,c  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^c Chalmers University of Technology   (Sweden)

Author keywords

Citrate synthase; Genomic DNA sequencing; Hexose transporter; Histone deacetylase; MTH1; Pyruvate decarboxylase; Reverse engineering; Yeast

Indexed keywords

CARBON; CITRATE SYNTHASE; GENOMIC DNA; GLUCOSE; GLUCOSE TRANSPORTER; HISTONE DEACETYLASE; PYRUVATE DECARBOXYLASE; SUGAR; CULTURE MEDIUM; HXT2 PROTEIN, S CEREVISIAE; MTH1 PROTEIN, S CEREVISIAE; RPD3 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADAPTATION; ALLELE; ARTICLE; BIOENGINEERING; CARBOHYDRATE METABOLISM; CARBON SOURCE; CIT1 GENE; CONTROLLED STUDY; DNA MODIFICATION; DNA SEQUENCE; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; GENE DELETION; GROWTH RATE; HXT2 GENE; MTH1 GENE; NONHUMAN; POINT MUTATION; RPD3 GENE; SIGNAL TRANSDUCTION; CULTURE MEDIUM; DEFICIENCY; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CULTURE MEDIA; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HISTONE DEACETYLASES; MUTATION; PYRUVATE DECARBOXYLASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84938561675     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0305-6     Document Type: Article

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