Physicochemical characterisation of rVIII-SingleChain, a novel recombinant single-chain factor VIII

Thrombosis Research

Volumn 136, Issue 2, 2015, Pages 388-395

  Schmidbauer, Stefan ^a   Witzel, Reinhild ^a   Robbel, Lars ^a   Sebastian, Petra ^a   Grammel, Nicolas ^b   Metzner, Hubert J ^a   Schulte, Stefan ^a  

^a CSL BEHRING GMBH   (Germany)

^b GlycoThera GmbH   (Germany)

Author keywords

Factor VIII; Physicochemical; Recombinant; rVIII SingleChain

Indexed keywords

FLUORESCENT DYE; GLYCAN; PEPTIDE; RECOMBINANT BLOOD CLOTTING FACTOR 8; THROMBIN; TRYPSIN; TYROSINE; BLOOD CLOTTING FACTOR 8; FACTOR VIII-FC FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; PEPTIDE FRAGMENT; PROTEIN BINDING; TYROSINE O-SULFATE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NONHUMAN; PHYSICAL CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PURIFICATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; TIME OF FLIGHT MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HUMAN; MOLECULAR GENETICS; MOLECULAR WEIGHT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; FACTOR VIII; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TYROSINE;

EID: 84938556132     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2015.05.005     Document Type: Article

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