-
1
-
-
84855994257
-
Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern
-
Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A: Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care 16(1):R12, 2012.
-
(2012)
Crit Care
, vol.16
, Issue.1
, pp. R12
-
-
Heffernan, D.S.1
Monaghan, S.F.2
Thakkar, R.K.3
Machan, J.T.4
Cioffi, W.G.5
Ayala, A.6
-
2
-
-
77958534644
-
Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
-
de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC: Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 14(5):R192, 2010.
-
(2010)
Crit Care
, vol.14
, Issue.5
, pp. R192
-
-
De Jager, C.P.1
Van Wijk, P.T.2
Mathoera, R.B.3
De Jongh-Leuvenink, J.4
Van Der Poll, T.5
Wever, P.C.6
-
3
-
-
84930084195
-
Persistent lymphopenia after diagnosis of sepsis predicts mortality
-
Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS: Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock 42(5):383-391, 2014.
-
(2014)
Shock
, vol.42
, Issue.5
, pp. 383-391
-
-
Drewry, A.M.1
Samra, N.2
Skrupky, L.P.3
Fuller, B.M.4
Compton, S.M.5
Hotchkiss, R.S.6
-
4
-
-
0030976184
-
Lymphocytopenia in a hospital populationV what does it signify?
-
Castelino DJ, McNair P, Kay TW: Lymphocytopenia in a hospital populationV what does it signify? Aust N Z J Med 27(2):170-174, 1997.
-
(1997)
Aust N Z J Med
, vol.27
, Issue.2
, pp. 170-174
-
-
Castelino, D.J.1
McNair, P.2
Kay, T.W.3
-
5
-
-
77957690699
-
Early assessment of leukocyte alterations at diagnosis of septic shock
-
Venet F, Davin F, Guignant C, Larue A, Cazalis MA, Darbon R, Allombert C, Mougin B, Malcus C, Poitevin-Later F, et al. Early assessment of leukocyte alterations at diagnosis of septic shock. Shock 34(4):358-363, 2010.
-
(2010)
Shock
, vol.34
, Issue.4
, pp. 358-363
-
-
Venet, F.1
Davin, F.2
Guignant, C.3
Larue, A.4
Cazalis, M.A.5
Darbon, R.6
Allombert, C.7
Mougin, B.8
Malcus, C.9
Poitevin-Later, F.10
-
6
-
-
84872059919
-
Decreased T-cell repertoire diversity in sepsis: A preliminary study
-
Venet F, Filipe-Santos O, Lepape A, Malcus C, Poitevin-Later F, Grives A, Plantier N, Pasqual N, Monneret G: Decreased T-cell repertoire diversity in sepsis: a preliminary study. Crit Care Med 41(1):111-119, 2013.
-
(2013)
Crit Care Med
, vol.41
, Issue.1
, pp. 111-119
-
-
Venet, F.1
Filipe-Santos, O.2
Lepape, A.3
Malcus, C.4
Poitevin-Later, F.5
Grives, A.6
Plantier, N.7
Pasqual, N.8
Monneret, G.9
-
7
-
-
84874938284
-
Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly
-
Inoue S, Suzuki-Utsunomiya K, Okada Y, Taira T, Iida Y, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, et al. Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly. Crit Care Med 41(3):810-819, 2013.
-
(2013)
Crit Care Med
, vol.41
, Issue.3
, pp. 810-819
-
-
Inoue, S.1
Suzuki-Utsunomiya, K.2
Okada, Y.3
Taira, T.4
Iida, Y.5
Miura, N.6
Tsuji, T.7
Yamagiwa, T.8
Morita, S.9
Chiba, T.10
-
8
-
-
6444244641
-
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome
-
Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L, Tattevin P, Thomas R, Fauchet R, Drenou B: Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 18(6): 487-494, 2002.
-
(2002)
Shock
, vol.18
, Issue.6
, pp. 487-494
-
-
Le Tulzo, Y.1
Pangault, C.2
Gacouin, A.3
Guilloux, V.4
Tribut, O.5
Amiot, L.6
Tattevin, P.7
Thomas, R.8
Fauchet, R.9
Drenou, B.10
-
9
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
-
Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 1(6): 496-501, 2000.
-
(2000)
Nat Immunol
, vol.1
, Issue.6
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
Tinsley, K.W.4
Hui, J.J.5
Klender, P.6
Xanthoudakis, S.7
Roy, S.8
Black, C.9
Grimm, E.10
-
10
-
-
0033120115
-
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
-
Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ, Karl IE: Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162(7):4148-4156, 1999.
-
(1999)
J Immunol
, vol.162
, Issue.7
, pp. 4148-4156
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Knudson, C.M.3
Chang, K.C.4
Cobb, J.P.5
Osborne, D.F.6
Zollner, K.M.7
Buchman, T.G.8
Korsmeyer, S.J.9
Karl, I.E.10
-
11
-
-
52149119860
-
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis
-
Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, et al. Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock 30(2):127-134, 2008.
-
(2008)
Shock
, vol.30
, Issue.2
, pp. 127-134
-
-
Schwulst, S.J.1
Muenzer, J.T.2
Peck-Palmer, O.M.3
Chang, K.C.4
Davis, C.G.5
McDonough, J.S.6
Osborne, D.F.7
Walton, A.H.8
Unsinger, J.9
McDunn, J.E.10
-
12
-
-
77954183132
-
Immunotherapy for sepsisVa new approach against an ancient foe
-
Hotchkiss RS, Opal S: Immunotherapy for sepsisVa new approach against an ancient foe. N Engl J Med 363(1):87-89, 2010.
-
(2010)
N Engl J Med
, vol.363
, Issue.1
, pp. 87-89
-
-
Hotchkiss, R.S.1
Opal, S.2
-
13
-
-
0036672918
-
Maintaining the norm: T-cell homeostasis
-
Jameson SC: Maintaining the norm: T-cell homeostasis. Nat Rev Immunol 2(8): 547-556, 2002.
-
(2002)
Nat Rev Immunol
, vol.2
, Issue.8
, pp. 547-556
-
-
Jameson, S.C.1
-
14
-
-
77949317183
-
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
-
Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol 184(3):1401-1409, 2010.
-
(2010)
J Immunol
, vol.184
, Issue.3
, pp. 1401-1409
-
-
Inoue, S.1
Unsinger, J.2
Davis, C.G.3
Muenzer, J.T.4
Ferguson, T.A.5
Chang, K.6
Osborne, D.F.7
Clark, A.T.8
Coopersmith, C.M.9
McDunn, J.E.10
-
15
-
-
77951648850
-
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
-
Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol 184(7):3768-3779, 2010.
-
(2010)
J Immunol
, vol.184
, Issue.7
, pp. 3768-3779
-
-
Unsinger, J.1
McGlynn, M.2
Kasten, K.R.3
Hoekzema, A.S.4
Watanabe, E.5
Muenzer, J.T.6
McDonough, J.S.7
Tschoep, J.8
Ferguson, T.A.9
McDunn, J.E.10
-
16
-
-
84868549577
-
IL-7 restores lymphocyte functions in septic patients
-
Venet F, Foray AP, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G: IL-7 restores lymphocyte functions in septic patients. J Immunol 189(10):5073-5081, 2012.
-
(2012)
J Immunol
, vol.189
, Issue.10
, pp. 5073-5081
-
-
Venet, F.1
Foray, A.P.2
Villars-Mechin, A.3
Malcus, C.4
Poitevin-Later, F.5
Lepape, A.6
Monneret, G.7
-
17
-
-
79957888573
-
Mechanisms of HIV-associated lymphocyte apoptosis: 2010
-
Cummins NW, Badley AD: Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis 1:e99, 2010.
-
(2010)
Cell Death Dis
, vol.1
, pp. e99
-
-
Cummins, N.W.1
Badley, A.D.2
-
18
-
-
0035138982
-
Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: Implications for T-cell homeostasis
-
Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM: Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7(1):73-79, 2001.
-
(2001)
Nat Med
, vol.7
, Issue.1
, pp. 73-79
-
-
Napolitano, L.A.1
Grant, R.M.2
Deeks, S.G.3
Schmidt, D.4
De Rosa, S.C.5
Herzenberg, L.A.6
Herndier, B.G.7
Andersson, J.8
McCune, J.M.9
-
19
-
-
22944469422
-
IL-15 and HIV infection: Lessons for immunotherapy and vaccination
-
Ahmad A, Ahmad R, Iannello A, Toma E, Morisset R, Sindhu ST: IL-15 and HIV infection: lessons for immunotherapy and vaccination. Curr HIV Res 3(3): 261-270, 2005.
-
(2005)
Curr HIV Res
, vol.3
, Issue.3
, pp. 261-270
-
-
Ahmad, A.1
Ahmad, R.2
Iannello, A.3
Toma, E.4
Morisset, R.5
Sindhu, S.T.6
-
20
-
-
34250890678
-
IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells
-
Sandau MM, Winstead CJ, Jameson SC: IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol 179(1):120-125, 2007.
-
(2007)
J Immunol
, vol.179
, Issue.1
, pp. 120-125
-
-
Sandau, M.M.1
Winstead, C.J.2
Jameson, S.C.3
-
21
-
-
84873339299
-
Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012
-
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41(2):580-637, 2013.
-
(2013)
Crit Care Med
, vol.41
, Issue.2
, pp. 580-637
-
-
Dellinger, R.P.1
Levy, M.M.2
Rhodes, A.3
Annane, D.4
Gerlach, H.5
Opal, S.M.6
Sevransky, J.E.7
Sprung, C.L.8
Douglas, I.S.9
Jaeschke, R.10
-
22
-
-
84862490519
-
Acute respiratory distress syndrome: The Berlin Definition
-
Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS: Acute respiratory distress syndrome: the Berlin Definition. JAMA 307(23):2526-2533, 2012.
-
(2012)
JAMA
, vol.307
, Issue.23
, pp. 2526-2533
-
-
Ranieri, V.M.1
Rubenfeld, G.D.2
Thompson, B.T.3
Ferguson, N.D.4
Caldwell, E.5
Fan, E.6
Camporota, L.7
Slutsky, A.S.8
-
23
-
-
34247235247
-
Acute Kidney Injury Network: Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury
-
Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31, 2007.
-
(2007)
Crit Care
, vol.11
, Issue.2
, pp. R31
-
-
Mehta, R.L.1
Kellum, J.A.2
Shah, S.V.3
Molitoris, B.A.4
Ronco, C.5
Warnock, D.G.6
Levin, A.7
-
24
-
-
84871774938
-
-
version 4.0
-
National Cancer Institute: common terminology criteria for adverse events (CTCAE), version 4.0.Available at: (http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE- 4.03-2010-06-14-QuickReference-8.5x11.pdf)
-
Common Terminology Criteria for Adverse Events (CTCAE)
-
-
-
25
-
-
0141542480
-
Real-time reverse transcription-PCR assay for future management of ERBB2- based clinical applications
-
Bieche I, Onody P, Laurendeau I, Olivi M, Vidaud D, Lidereau R, Vidaud M: Real-time reverse transcription-PCR assay for future management of ERBB2- based clinical applications. Clin Chem 45(8):1148-1156, 1999.
-
(1999)
Clin Chem
, vol.45
, Issue.8
, pp. 1148-1156
-
-
Bieche, I.1
Onody, P.2
Laurendeau, I.3
Olivi, M.4
Vidaud, D.5
Lidereau, R.6
Vidaud, M.7
-
26
-
-
84255194001
-
Immunosuppression in patients who die of sepsis and multiple organ failure
-
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD2nd, Kreisel D, Krupnick AS, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306(23):2594-2605, 2011.
-
(2011)
JAMA
, vol.306
, Issue.23
, pp. 2594-2605
-
-
Boomer, J.S.1
To, K.2
Chang, K.C.3
Takasu, O.4
Osborne, D.F.5
Walton, A.H.6
Bricker, T.L.7
Jarman, I.I.S.D.8
Kreisel, D.9
Krupnick, A.S.10
-
27
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27(7):1230-1251, 1999.
-
(1999)
Crit Care Med
, vol.27
, Issue.7
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Freeman, B.D.3
Tinsley, K.W.4
Cobb, J.P.5
Matuschak, G.M.6
Buchman, T.G.7
Karl, I.E.8
-
28
-
-
79952236016
-
An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes
-
Vaki I, Kranidioti H, Karagianni V, Spyridaki A, Kotsaki A, Routsi C, Giamarellos-Bourboulis EJ: An early circulating factor in severe sepsis modulates apoptosis of monocytes and lymphocytes. J Leukoc Biol 89(3):343-349, 2011.
-
(2011)
J Leukoc Biol
, vol.89
, Issue.3
, pp. 343-349
-
-
Vaki, I.1
Kranidioti, H.2
Karagianni, V.3
Spyridaki, A.4
Kotsaki, A.5
Routsi, C.6
Giamarellos-Bourboulis, E.J.7
-
29
-
-
84874260721
-
Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice
-
Inoue S, Sato T, Suzuki-Utsunomiya K, Komori Y, Hozumi K, Chiba T, Yahata T, Nakai K, Inokuchi S: Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice. Shock 39(3):311-316, 2013.
-
(2013)
Shock
, vol.39
, Issue.3
, pp. 311-316
-
-
Inoue, S.1
Sato, T.2
Suzuki-Utsunomiya, K.3
Komori, Y.4
Hozumi, K.5
Chiba, T.6
Yahata, T.7
Nakai, K.8
Inokuchi, S.9
-
30
-
-
33847401104
-
Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis
-
Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A, Hotchkiss RS: Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis. FASEB 21(3): 708-719, 2007.
-
(2007)
FASEB
, vol.21
, Issue.3
, pp. 708-719
-
-
Chang, K.C.1
Unsinger, J.2
Davis, C.G.3
Schwulst, S.J.4
Muenzer, J.T.5
Strasser, A.6
Hotchkiss, R.S.7
-
31
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE: Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 174(8):5110-5118, 2005.
-
(2005)
J Immunol
, vol.174
, Issue.8
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
Wagner, T.H.4
Coopersmith, C.M.5
Karl, I.E.6
|