-
1
-
-
84931569160
-
Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): A randomised, open-label trial
-
Hézode C, Asselah T, Reddy KR et al. Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet 385(9986), 2502-2509 (2015).
-
(2015)
Lancet
, vol.385
, Issue.9986
, pp. 2502-2509
-
-
Hézode, C.1
Asselah, T.2
Reddy, K.R.3
-
2
-
-
84898669547
-
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
-
Afdhal N, Reddy KR, Nelson DR et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N. Engl. J. Med. 370 (16), 1483-1493 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, Issue.16
, pp. 1483-1493
-
-
Afdhal, N.1
Reddy, K.R.2
Nelson, D.R.3
-
3
-
-
84878459431
-
Reactivation of latent HIV by histone deacetylase inhibitors
-
Shirakawa K, Chavez L, Hakre S, Calvanese V, Verdin E. Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol. 21(6), 277-285 (2013).
-
(2013)
Trends Microbiol.
, vol.21
, Issue.6
, pp. 277-285
-
-
Shirakawa, K.1
Chavez, L.2
Hakre, S.3
Calvanese, V.4
Verdin, E.5
-
4
-
-
84878873135
-
Targeting HIV latency: Pharmacologic strategies toward eradication
-
Xing S, Siliciano RF. Targeting HIV latency: pharmacologic strategies toward eradication. Drug Discov. Today 18(11-12), 541-551 (2013).
-
(2013)
Drug Discov. Today
, vol.18
, Issue.11-12
, pp. 541-551
-
-
Xing, S.1
Siliciano, R.F.2
-
5
-
-
84903615913
-
Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1
-
Siliciano JD, Siliciano R F. Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1. J. Allergy Clin. Immun. 134(1), 12-19 (2014).
-
(2014)
J. Allergy Clin. Immun.
, vol.134
, Issue.1
, pp. 12-19
-
-
Siliciano, J.D.1
Siliciano, R.F.2
-
6
-
-
84925842804
-
Towards an HIV-1 cure: Measuring the latent reservoir
-
Bruner KM, Hosmane NN, Siliciano RF. Towards an HIV-1 cure: measuring the latent reservoir. Trends Microbiol. 23(4), 192-203 (2015).
-
(2015)
Trends Microbiol.
, vol.23
, Issue.4
, pp. 192-203
-
-
Bruner, K.M.1
Hosmane, N.N.2
Siliciano, R.F.3
-
7
-
-
84925604110
-
Regulation of HIV-1 latency by chromatin structure and nuclear architecture
-
Lusic M, Giacca M. Regulation of HIV-1 latency by chromatin structure and nuclear architecture. J. Mol. Biol. 427(3), 688-694 (2015).
-
(2015)
J. Mol. Biol.
, vol.427
, Issue.3
, pp. 688-694
-
-
Lusic, M.1
Giacca, M.2
-
8
-
-
84929094317
-
Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1
-
Campbell GR, Bruckman RS, Chu YL, Spector SA. Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1. J. Biol. Chem. 290(8), 5028-5040 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, Issue.8
, pp. 5028-5040
-
-
Campbell, G.R.1
Bruckman, R.S.2
Chu, Y.L.3
Spector, S.A.4
-
9
-
-
56149115918
-
Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
-
Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 48(5), 1420-1429 (2008).
-
(2008)
Hepatology
, vol.48
, Issue.5
, pp. 1420-1429
-
-
Miura, K.1
Taura, K.2
Kodama, Y.3
Schnabl, B.4
Brenner, D.A.5
-
10
-
-
84867692347
-
Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus
-
Liu H, Trinh TL, Dong H, Keith R, Nelson D, Liu C. Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus. PLoS ONE 7(10), e46631 (2012).
-
(2012)
PLoS ONE
, vol.7
, Issue.10
, pp. e46631
-
-
Liu, H.1
Trinh, T.L.2
Dong, H.3
Keith, R.4
Nelson, D.5
Liu, C.6
-
11
-
-
84901752244
-
Low hepcidin triggers hepatic iron accumulation in patients with hepatitis C
-
Horl WH, Schmidt A. Low hepcidin triggers hepatic iron accumulation in patients with hepatitis C. Nephrol. Dial. Transpl. 29 (6), 1141-1144 (2014).
-
(2014)
Nephrol. Dial. Transpl.
, vol.29
, Issue.6
, pp. 1141-1144
-
-
Horl, W.H.1
Schmidt, A.2
-
12
-
-
84880918097
-
Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy
-
López-Rodríguez R, Hernández-Bartolomé Á, Borque MJ et al. Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy. Genes Immun. 14(5), 317-324 (2013).
-
(2013)
Genes Immun.
, vol.14
, Issue.5
, pp. 317-324
-
-
López-Rodríguez, R.1
Hernández-Bartolomé Á.2
Borque, M.J.3
-
13
-
-
84881390839
-
Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication
-
Sato A, Saito Y, Sugiyama K et al. Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. J. Cell. Biochem. 114 (9), 1987-1996 (2013).
-
(2013)
J. Cell. Biochem.
, vol.114
, Issue.9
, pp. 1987-1996
-
-
Sato, A.1
Saito, Y.2
Sugiyama, K.3
-
14
-
-
84885177103
-
Benzohydroxamic acids as potent and selective anti-HCV agents
-
Kozlov MV, Kleymenova AA, Romanova LI et al. Benzohydroxamic acids as potent and selective anti-HCV agents. Bioorg. Med. Chem. Lett. 23(21), 5936-5940 (2013).
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, Issue.21
, pp. 5936-5940
-
-
Kozlov, M.V.1
Kleymenova, A.A.2
Romanova, L.I.3
-
15
-
-
84906228124
-
Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes
-
Kozlov MV, Kleymenova AA, Konduktorov KA, Malikova AZ, Kochetkov SN. Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes. Biochemistry (Mosc.) 79(7), 637-642 (2014).
-
(2014)
Biochemistry (Mosc.)
, vol.79
, Issue.7
, pp. 637-642
-
-
Kozlov, M.V.1
Kleymenova, A.A.2
Konduktorov, K.A.3
Malikova, A.Z.4
Kochetkov, S.N.5
-
16
-
-
84937765299
-
Pyridine hydroxamic acids are specifc anti-HCV agents affecting HDAC6
-
Kozlov MV, Kleymenova AA, Romanova LI et al. Pyridine hydroxamic acids are specifc anti-HCV agents affecting HDAC6. Bioorg. Med. Chem. Lett. 25(11), 2382-2385 (2015).
-
(2015)
Bioorg. Med. Chem. Lett.
, vol.25
, Issue.11
, pp. 2382-2385
-
-
Kozlov, M.V.1
Kleymenova, A.A.2
Romanova, L.I.3
-
17
-
-
21144444486
-
HDAC6 Regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJM, Gaillard S et al. HDAC6 Regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18(5), 601-607 (2005).
-
(2005)
Mol. Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
Pjm, M.2
Gaillard, S.3
-
18
-
-
47749156827
-
HDAC6 is a specifc deacetylase of peroxiredoxins and is involved in redox regulation
-
Parmigiani RB, Xu WS, Venta-Perez G et al. HDAC6 is a specifc deacetylase of peroxiredoxins and is involved in redox regulation. Proc. Natl Acad. Sci. USA 105(28), 9633-9638 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.28
, pp. 9633-9638
-
-
Parmigiani, R.B.1
Xu, W.S.2
Venta-Perez, G.3
-
19
-
-
84921458292
-
Hydroxamic acids block replication of hepatitis C virus
-
Ai T, Xu Y, Qiu L, Geraghty RJ, Chen L. Hydroxamic acids block replication of hepatitis C virus. J. Med. Chem. 58(2), 785-800 (2015).
-
(2015)
J. Med. Chem.
, vol.58
, Issue.2
, pp. 785-800
-
-
Ai, T.1
Xu, Y.2
Qiu, L.3
Geraghty, R.J.4
Chen, L.5
-
20
-
-
84903710585
-
"Old friends in new guise": Exploiting privileged structures for scaffold re-evolution/refning
-
Song Y, Chen W, Kang D et al. "Old friends in new guise": exploiting privileged structures for scaffold re-evolution/refning. Comb. Chem. High Throughput Screen. 17(6), 536-553 (2014).
-
(2014)
Comb. Chem. High Throughput Screen.
, vol.17
, Issue.6
, pp. 536-553
-
-
Song, Y.1
Chen, W.2
Kang, D.3
-
21
-
-
84866247757
-
Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors
-
Li X, Zhan P, Liu H et al. Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors. Bioorg. Med. Chem. 20 (18), 5527-5536 (2012).
-
(2012)
Bioorg. Med. Chem.
, vol.20
, Issue.18
, pp. 5527-5536
-
-
Li, X.1
Zhan, P.2
Liu, H.3
-
22
-
-
84902185122
-
Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate
-
Song Y, Lin X, Kang D et al. Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate. Eur. J. Med. Chem. 82, 293-307 (2014).
-
(2014)
Eur. J. Med. Chem.
, vol.82
, pp. 293-307
-
-
Song, Y.1
Lin, X.2
Kang, D.3
-
23
-
-
0034681683
-
The Nobel chronicles. 1988: James Whyte Black, (b 1924), Gertrude Elion (1918-99), and George H Hitchings 1905-98)
-
Raju TN. The Nobel chronicles. 1988: James Whyte Black, (b 1924), Gertrude Elion (1918-99), and George H Hitchings (1905-98). Lancet 355, 1022 (2000).
-
(2000)
Lancet
, vol.355
, pp. 1022
-
-
Raju, T.N.1
-
24
-
-
84903743047
-
Heterocycle-thioacetic acid motif: A privileged molecular scaffold with potent, broad-ranging pharmacological activities
-
Song Y, Zhan P, Liu X. Heterocycle-thioacetic acid motif: a privileged molecular scaffold with potent, broad-ranging pharmacological activities. Curr. Pharm. Design 19 (40), 7141-7154 (2013).
-
(2013)
Curr. Pharm. Design
, vol.19
, Issue.40
, pp. 7141-7154
-
-
Song, Y.1
Zhan, P.2
Liu, X.3
-
25
-
-
84876720656
-
Privileged scaffolds or promiscuous binders: A glance of pyrrolo[2, 1-f][1, 2, 4] triazines and related bridgehead nitrogen heterocycles in medicinal chemistry
-
Song Y, Zhan P, Zhang Q, Liu X. Privileged scaffolds or promiscuous binders: a glance of pyrrolo[2, 1-f][1, 2, 4] triazines and related bridgehead nitrogen heterocycles in medicinal chemistry. Curr. Pharm. Design 19 (8), 1528-1548 (2013).
-
(2013)
Curr. Pharm. Design
, vol.19
, Issue.8
, pp. 1528-1548
-
-
Song, Y.1
Zhan, P.2
Zhang, Q.3
Liu, X.4
|