Moderate intensity exercise mediates comparable increases in exhaled chloride as albuterol in individuals with cystic fibrosis

Respiratory Medicine

Volumn 109, Issue 8, 2015, Pages 1001-1011

  Wheatley, Courtney M ^a,b   Baker, Sarah E ^a,b   Morgan, Mary A ^a   Martinez, Marina G ^a,c   Liu, Bo ^d   Rowe, Steven M ^d   Morgan, Wayne J ^a   Wong, Eric C ^a   Karpen, Stephen R ^a   Snyder, Eric M ^e  

^a UNIVERSITY OF ARIZONA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Airway surface liquid; Beta 2 adrenergic receptor (ADBR2); Epithelial sodium channels (ENaC); Exhaled breath condensate (EBC); Nasal potential difference (NPD); Purinergic receptor (P2Y2)

Indexed keywords

AMILORIDE; CHLORIDE; EPITHELIAL SODIUM CHANNEL; SALBUTAMOL; SODIUM; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT;

ADOLESCENT; ADULT; ARTICLE; BREATH ANALYSIS; CHLORIDE TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLING; CYSTIC FIBROSIS; ELECTRIC POTENTIAL; EXERCISE INTENSITY; EXHALED BREATH CONDENSATE; FEMALE; HUMAN; MALE; NASAL POTENTIAL DIFFERENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT PARAMETERS; SODIUM TRANSPORT; CROSSOVER PROCEDURE; DOSE RESPONSE; EXERCISE TOLERANCE; KINESIOTHERAPY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADULT; ALBUTEROL; CHLORIDES; CROSS-OVER STUDIES; CYSTIC FIBROSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXERCISE THERAPY; EXERCISE TOLERANCE; FEMALE; HUMANS; MALE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84938417999     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2015.05.018     Document Type: Article

References (54)

1. R.C. Boucher Molecular insights into the physiology of the 'thin film' of airway surface liquid J. Physiol. 516 Pt 3 1999 631 638
2. H. Matsui, B.R. Grubb, R. Tarran, and et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease Cell. 95 7 1998 1005 1015
3. M. Mall, B.R. Grubb, J.R. Harkema, W.K. O'Neal, and R.C. Boucher Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice Nat. Med. 10 5 2004 487 493
4. S.M. Rowe, S. Miller, and E.J. Sorscher Cystic fibrosis N. Engl. J. Med. 352 19 2005 1992 2001
5. J. Schneiderman-Walker, S.L. Pollock, M. Corey, and et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis J. Pediatr. 136 3 2000 304 310
6. D.M. Orenstein, B.A. Franklin, C.F. Doershuk, and et al. Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program Chest. 80 4 1981 392 398
7. T.J. Dwyer, J.A. Alison, Z.J. McKeough, E. Daviskas, and P.T. Bye Effects of exercise on respiratory flow and sputum properties in patients with cystic fibrosis Chest. 139 4 2011 870 877
8. D.R. Baldwin, A.L. Hill, D.G. Peckham, and A.J. Knox Effect of addition of exercise to chest physiotherapy on sputum expectoration and lung function in adults with cystic fibrosis Respir. Med. 88 1 1994 49 53
9. P.A. Nixon, D.M. Orenstein, S.F. Kelsey, and C.F. Doershuk The prognostic value of exercise testing in patients with cystic fibrosis N. Engl. J. Med. 327 25 1992 1785 1788
10. P. Pianosi, J. Leblanc, and A. Almudevar Peak oxygen uptake and mortality in children with cystic fibrosis Thorax. 60 1 2005 50 54
11. S. Alsuwaidan, A. Li Wan Po, G. Morrison, and et al. Effect of exercise on the nasal transmucosal potential difference in patients with cystic fibrosis and normal subjects Thorax. 49 12 1994 1249 1250
12. A. Hebestreit, U. Kersting, B. Basler, R. Jeschke, and H. Hebestreit Exercise inhibits epithelial sodium channels in patients with cystic fibrosis Am. J. Respir. Crit. Care Med. 164 3 2001 443 446
13. Schmitt L, Wiebel M, Frese F, et al. Exercise reduces airway Na-reabsorption in cystic fibrosis but not in exercise asthma. Eur. Respir. J.
14. C. Haws, M.E. Krouse, Y. Xia, D.C. Gruenert, and J.J. Wine CFTR channels in immortalized human airway cells Am. J. physiology 263 6 Pt 1 1992 L692 L707
15. T.C. Hwang, G. Nagel, A.C. Nairn, and D.C. Gadsby Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis Proc. Natl. Acad. Sci. U. S. A. 91 11 1994 4698 4702
16. X.J. Chen, D.C. Eaton, and L. Jain Beta-adrenergic regulation of amiloride-sensitive lung sodium channels Am. J. physiology. Lung Cell. Mol. physiology 282 4 2002 L609 L620
17. M.J. Stutts, C.M. Canessa, J.C. Olsen, and et al. CFTR as a cAMP-dependent regulator of sodium channels Science. 269 5225 1995 847 850
18. M.J. Stutts, B.C. Rossier, and R.C. Boucher Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics J. Biol. Chem. 272 22 1997 14037 14040
19. K. Kunzelmann, R. Schreiber, R. Nitschke, and M. Mall Control of epithelial Na+ conductance by the cystic fibrosis transmembrane conductance regulator Pflugers Archiv: Eur. J. physiology 440 2 2000 193 201
20. L.A. Chambers, B.M. Rollins, and R. Tarran Liquid movement across the surface epithelium of large airways Respir. Physiol. Neurobiol. 159 3 2007 256 270
21. + channels in human normal and cystic fibrosis airway epithelia Pediatr. Res. 53 4 2003 608 618
22. B. Nilius, and G. Droogmans Amazing chloride channels: an overview Acta Physiol. Scand. 177 2 2003 119 147
23. G. Com, and J.P. Clancy Adenosine receptors, cystic fibrosis, and airway hydration Handb. Exp. Pharmacol. 193 2009 363 381
24. C.M. Wheatley, B.W. Wilkins, and E.M. Snyder Exercise is medicine in cystic fibrosis Exerc Sport Sci. Rev. 39 3 2011 155 160
25. C.M. Wheatley, S.E. Baker, M.A. Morgan, M.G. Martinez, W.J. Morgan, E.C. Wong, S.R. Karpen, and E.M. Snyder Effects of exercise intensity compared to albuterol in individuals with cystic fibrosis Respir. Med. 109 4 2014 463 474
26. C.M. Wheatley, W.J. Morgan, N.A. Cassuto, and et al. Exhaled breath condensate detects baseline reductions in chloride and increases in response to albuterol in cystic fibrosis patients Clin. Med. Insights: Circulatory, Respir. Pulm. Med. 7 2013 79 90
27. R.M. Effros, J. Biller, B. Foss, and et al. A simple method for estimating respiratory solute dilution in exhaled breath condensates Am. J. Respir. Crit. Care Med. 168 12 2003 1500 1505
28. S.M. Rowe, B. Liu, A. Hill, and et al. Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation PLoS One. 8 7 2013 e66955
29. J.P. Clancy, Z. Bebök, F. Ruiz, and et al. Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis Am. J. Respir. Crit. Care Med. 163 7 2001 1683 1692
30. S.M. Rowe, F. Accurso, and J.P. Clancy Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials Proc. Am. Thorac. Soc. 4 4 2007 387 398
31. F.J. Accurso, S.M. Rowe, J.P. Clancy, and et al. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation N. Engl. J. Med. 363 21 2010 1991 2003
32. M. Wilschanski, Y. Yahav, Y. Yaacov, and et al. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations N. Engl. J. Med. 349 15 2003 1433 1441
33. G.M. Solomon, M.W. Konstan, M. Wilschanski, and et al. An international randomized multicenter comparison of nasal potential difference techniques Chest 138 4 2010 919 928
34. I. Sermet-Gaudelus, E. Girodon, D. Sands, and et al. Clinical phenotype and genotype of children with borderline sweat test and abnormal nasal epithelial chloride transport Am. J. Respir. Crit. Care Med. 182 7 2010 929 936
35. S.M. Rowe, F. Accurso, and J.P. Clancy Detection of cystic fibrosis transmembrane conductance regulator activity in early-phase clinical trials Proc. Am. Thorac. Soc. 4 4 2007 387 398
36. M. Knowles, J. Gatzy, and R. Boucher Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis N. Engl. J. Med. 305 25 1981 1489 1495
37. D. Penque, F. Mendes, S. Beck, and et al. Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells Laboratory investigation; a J. Tech. methods pathology 80 6 2000 857 868
38. M.L. Drumm, D.J. Wilkinson, L.S. Smit, and et al. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes Science 254 5039 1991 1797 1799
39. W. Dalemans, P. Barbry, G. Champigny, and et al. Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation Nature 354 6354 1991 526 528
40. F. Delavoie, M. Molinari, M. Milliot, and et al. Salmeterol restores secretory functions in cystic fibrosis airway submucosal gland serous cells Am. J. Respir. cell Mol. Biol. 40 4 2009 388 397
41. J.R. Riordan Assembly of functional CFTR chloride channels Annu. Rev. physiology 67 2005 701 718
42. G.L. Lukacs, G. Segal, N. Kartner, S. Grinstein, and F. Zhang Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation Biochem. J. 328 Pt 2 1997 353 361
43. L. Schmitt, M. Wiebel, F. Frese, and et al. Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma Eur. Respir. J. 37 2 2011 342 348
44. B. Button, and R.C. Boucher Role of mechanical stress in regulating airway surface hydration and mucus clearance rates Respir. Physiol. Neurobiol. 163 1-3 2008 189 201
45. M. Rosenfeld, R.L. Gibson, S. McNamara, and et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis Pediatr. Pulmonol. 32 5 2001 356 366
46. P.A. de Jong, A. Lindblad, L. Rubin, and et al. Progression of lung disease on computed tomography and pulmonary function tests in children and adults with cystic fibrosis Thorax 61 1 2006 80 85
47. A.G. Durmowicz, K.A. Witzmann, C.J. Rosebraugh, and B.A. Chowdhury Response. Chest 144 4 2013 1418 1419
48. A.G. Durmowicz, K.A. Witzmann, C.J. Rosebraugh, and B.A. Chowdhury Change in sweat chloride as a clinical end point in cystic fibrosis clinical trials: the ivacaftor experience Chest. 143 1 2013 14 18
49. S.L. Heltshe, N. Mayer-Hamblett, and S.M. Rowe Understanding the relationship between sweat chloride and lung function in cystic fibrosis Chest. 144 4 2013 1418
50. S.E. Baker, C.M. Wheatley, N.A. Cassuto, W.T. Foxx-Lupo, R. Sprissler, and E.M. Snyder Genetic variation of alphaENaC influences lung diffusion during exercise in humans Respir. Physiol. Neurobiol. 179 2-3 2011 212 218
51. S.E. Baker, E.C. Wong, C.M. Wheatley, and et al. Genetic variation of SCNN1A influences lung diffusing capacity in cystic fibrosis Med. Sci. Sports Exerc. 12 2012 Dec 2315 2321
52. I. Horvath, J. Hunt, P.J. Barnes, and et al. Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J. 26 3 2005 523 548
53. R.M. Effros, K.W. Hoagland, M. Bosbous, and et al. Dilution of respiratory solutes in exhaled condensates Am. J. Respir. Crit. Care Med. 165 5 2002 663 669
54. C.M. Wheatley, N.A. Cassuto, W.T. Foxx-Lupo, and E.M. Snyder Variability in measures of exhaled breath na, influence of pulmonary blood flow and salivary na Clin. Med. Insights Circ. Respir. Pulm. Med. 4 2010 25 34