Effects of exercise intensity compared to albuterol in individuals with cystic fibrosis

Respiratory Medicine

Volumn 109, Issue 4, 2015, Pages 463-474

  Wheatley, Courtney M ^a,b   Baker, Sarah E ^a,c   Morgan, Mary A ^a   Martinez, Marina G ^a   Morgan, Wayne J ^a   Wong, Eric C ^a   Karpen, Stephen R ^a   Snyder, Eric M ^a,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Albuterol; Bronchodilation; Catecholamines; Cycle ergometer; Diffusion capacity of the lungs for nitric oxide; Submaximal exercise

Indexed keywords

ADRENALIN; NITRIC OXIDE; SALBUTAMOL; BRONCHODILATING AGENT;

ADULT; AEROBIC CAPACITY; ARTICLE; BICYCLE ERGOMETER; BICYCLE ERGOMETRY; BODY MASS; BODY SURFACE; BRONCHODILATATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; EXERCISE; EXERCISE INTENSITY; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GAS DIFFUSION; HEART OUTPUT; HUMAN; LUNG DIFFUSION CAPACITY; LUNG FUNCTION; MALE; MAXIMAL EXPIRATORY FLOW; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SPIROMETRY; WORKLOAD; YOUNG ADULT; ADOLESCENT; BLOOD GAS ANALYSIS; BREATHING EXERCISE; CROSSOVER PROCEDURE; DIFFUSION; DRUG EFFECTS; EXERCISE TEST; EXERCISE TOLERANCE; KINESIOTHERAPY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ALBUTEROL; BLOOD GAS ANALYSIS; BREATHING EXERCISES; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; CYSTIC FIBROSIS; EXERCISE TEST; EXERCISE THERAPY; EXERCISE TOLERANCE; FACILITATED DIFFUSION; FEMALE; HUMANS; MALE; NITRIC OXIDE; SPIROMETRY; TREATMENT OUTCOME;

EID: 84925728521     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2014.12.002     Document Type: Article

References (49)

1. D.M. Orenstein, B.A. Franklin, and C.F. Doershuk Exercise conditioning and cardiopulmonary fitness in cystic fibrosis. The effects of a three-month supervised running program Chest 80 4 1981 392 398
2. D.R. Baldwin, A.L. Hill, D.G. Peckham, and A.J. Knox Effect of addition of exercise to chest physiotherapy on sputum expectoration and lung function in adults with cystic fibrosis Respir Med 88 1 1994 49 53
3. T.J. Dwyer, J.A. Alison, Z.J. McKeough, E. Daviskas, and P.T. Bye Effects of exercise on respiratory flow and sputum properties in cystic fibrosis Chest 139 4 2011 870 877
4. P.A. Nixon, D.M. Orenstein, S.F. Kelsey, and C.F. Doershuk The prognostic value of exercise testing in patients with cystic fibrosis N Engl J Med 327 25 1992 1785 1788
5. L.B. Myers An exploratory study investigating factors associated with adherence to chest physiotherapy and exercise in adults with cystic fibrosis J Cyst Fibros 8 6 2009 425 427
6. W. Gruber, D.M. Orenstein, K.M. Braumann, and R. Beneke Interval exercise training in cystic fibrosis - effects on exercise capacity in severely affected adults J Cyst Fibros 13 1 2014 86 91
7. F.J. Moola, G.E. Faulkner, and J.E. Schneiderman "No time to play": perceptions toward physical activity in youth with cystic fibrosis Adapt Phys Act Q 29 1 2012 44 62
8. D. White, K. Stiller, and N. Haensel Adherence of adult cystic fibrosis patients with airway clearance and exercise regimens J Cyst Fibros 6 3 2007 163 170
9. S.A. Prasad, and F.J. Cerny Factors that influence adherence to exercise and their effectiveness: application to cystic fibrosis Pediatr Pulmonol 34 1 2002 66 72
10. J. Schneiderman-Walker, S.L. Pollock, and M. Corey A randomized controlled trial of a 3-year home exercise program in cystic fibrosis J Pediatr 136 3 2000 304 310
11. + transport Circ Res 96 9 2005 999 1005
12. G.M. Mutlu, W.J. Koch, and P. Factor Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport Am J Respir Crit Care Med 170 12 2004 1270 1275
13. 2+]i in human tracheal epithelial cells in primary culture J Cell Sci 107 10 1994 2899 2907
14. + transport is dependent on beta2-adrenergic receptor signaling Circ Res 94 8 2004 1091 1100
15. M. Salathe Effects of beta-agonists on airway epithelial cells J Allergy Clin Immunol 110 6 Suppl 2002 S275 S281
16. R.W. Gotshall Airway response during exercise and hyperpnoea in non-asthmatic and asthmatic individuals Sports Med 36 6 2006 513 527
17. C.K. Billington, and R.B. Penn Signaling and regulation of G protein-coupled receptors in airway smooth muscle Respir Res 4 2003 2
18. J.B. Warren, and N. Dalton A comparison of the bronchodilator and vasopressor effects of exercise levels of adrenaline in man Clin Sci 64 5 1983 475 479
19. B.D. Johnson, P.D. Scanlon, and K.C. Beck Regulation of ventilatory capacity during exercise in asthmatics J Appl Phys 79 3 1995 892 901
20. E.M. Snyder, K.C. Beck, N.M. Dietz, M.J. Joyner, S.T. Turner, and B.D. Johnson Influence of {beta}2-Adrenergic receptor genotype on airway function during exercise in healthy adults Chest 129 3 2006 762 770
21. J. Leipziger Control of epithelial transport via luminal P2 receptors Am J Physiol Renal Physiol 284 3 2003 F419 F432
22. + channel Clin Exp Pharmacol Physiol 36 10 2009 1016 1022
23. A. Hebestreit, U. Kersting, B. Basler, R. Jeschke, and H. Hebestreit Exercise inhibits epithelial sodium channels in patients with cystic fibrosis Am J Respir Crit Care Med 164 3 2001 443 446
24. L. Schmitt, M. Wiebel, and F. Frese Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma Eur Respir J 37 2 2011 342 348
25. C. Halfhide, H.J. Evans, and J. Couriel Inhaled bronchodilators for cystic fibrosis Cochrane Database Syst Rev 4 2005 CD003428
26. J.L. Colombo Long-acting bronchodilators in cystic fibrosis Curr Opin Pulm Med 9 6 2003 504 508
27. G.F. Fletcher, G. Balady, V.F. Froelicher, L.H. Hartley, W.L. Haskell, and M.L. Pollock Exercise standards. A statement for healthcare professionals from the American Heart Association. Writing Group Circulation 91 2 1995 580 615
28. G.A.V. Borg A category scale with ratio properties for intermodal and interindividual comparisons H. Geissler, P. Pezold, Psychophysial judgement and the process of perception 1982 Veb Deutsche Verlag Wissen Schaften Berlin 25 34
29. J.E. Hansen, D.Y. Sue, and K. Wasserman Predicted values for clinical exercise testing Am Rev Respir Dis 129 2 Pt 2 1984 S49 S55
30. D.M. Orenstein, M.F. Hovell, and M. Mulvihill Strength vs aerobic training in children with cystic fibrosis: a randomized controlled trial Chest 126 4 2004 1204 1214
31. E.M. Snyder, K.C. Beck, M.L. Hulsebus, J.F. Breen, E.A. Hoffman, and B.D. Johnson Short-term hypoxic exposure at rest and during exercise reduces lung water in healthy humans J Appl Phys 101 6 2006 1623 1632
32. E.M. Snyder, B.D. Johnson, and K.C. Beck An open-circuit method for determining lung diffusing capacity during exercise: comparison to rebreathe J Appl Phys 99 5 2005 1985 1991
33. C.M. Wheatley, J.C. Baldi, N.A. Cassuto, W.T. Foxx-Lupo, and E.M. Snyder Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes: alveolar-capillary membrane conductance in type 1 diabetes Eur J Appl Physiol 111 3 2011 567 578
34. C.M. Wheatley, W.T. Foxx-Lupo, and N.A. Cassuto Impaired lung diffusing capacity for nitric oxide and alveolar-capillary membrane conductance results in oxygen desaturation during exercise in patients with cystic fibrosis J Cyst Fibros 10 1 2011 45 53
35. F.J. Roughton, and R.E. Forster Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries J Appl Phys 11 2 1957 290 302
36. C.C. Hsia Recruitment of lung diffusing capacity: update of concept and application Chest 122 5 2002 1774 1783
37. R.M. Tamhane, R.L. Johnson Jr., and C.C. Hsia Pulmonary membrane diffusing capacity and capillary blood volume measured during exercise from nitric oxide uptake Chest 120 6 2001 1850 1856
38. C.C. Hsia, and P. Raskin The diabetic lung: relevance of alveolar microangiopathy for the use of inhaled insulin Am J Med 118 3 2005 205 211
39. H. Dressel, L. Filser, and R. Fischer Lung diffusing capacity for nitric oxide and carbon monoxide in relation to morphological changes as assessed by computed tomography in patients with cystic fibrosis BMC Pulm Med 9 2009 30
40. C.C. Hsia, L.F. Herazo, M. Ramanathan, and R.L. Johnson Jr. Cardiac output during exercise measured by acetylene rebreathing, thermodilution, and fick techniques J Appl Phys 78 4 1995 1612 1616
41. J. Saur, F. Trinkmann, and C. Doesch The impact of pulmonary disease on noninvasive measurement of cardiac output by the inert gas rebreathing method Lung 188 5 2010 433 440
42. R.J. Pierce, C.F. McDonald, C.A. Thuys, P.D. Rochford, and C.E. Barter Measurement of effective pulmonary blood flow by soluble gas uptake in patients with chronic airflow obstruction Thorax 42 8 1987 604 614
43. M.R. Miller, J. Hankinson, and V. Brusasco Standardisation of spirometry Eur Respir J 26 2 2005 319 338
44. J.L. Hankinson, J.R. Odencrantz, and K.B. Fedan Spirometric reference values from a sample of the general U.S. population Am J Respir Crit Care Med 159 1 1999 179 187
45. C.D. Borland, and T.W. Higenbottam A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide Eur Respir J 2 1 1989 56 63
46. J.A. Regnis, P.M. Donnelly, M. Robinson, J.A. Alison, and P.T. Bye Ventilatory mechanics at rest and during exercise in patients with cystic fibrosis Am J Respir Crit Care Med 154 5 1996 1418 1425
47. P.B. Davis, and M. Kaliner Autonomic nervous system abnormalities in cystic fibrosis J Chronic Dis 36 3 1983 269 278
48. P.B. Davis, M. Braunstein, and C. Jay Decreased adenosine 3′:5′-monophosphate response to isoproterenol in cystic fibrosis leukocytes Pediatr Res 12 6 1978 703 707
49. P.B. Davis, J.R. Shelhamer, and M. Kaliner Abnormal adrenergic and cholinergic sensitivity in cystic fibrosis N Engl J Med 302 26 1980 1453 1456