Implications of the apportionment of human genetic diversity for the apportionment of human phenotypic diversity

Studies in History and Philosophy of Science Part C :Studies in History and Philosophy of Biological and Biomedical Sciences

Volumn 52, Issue , 2015, Pages 32-45

  Edge, Michael D ^a   Rosenberg, Noah A ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Genetic differentiation; Population genetics; Quantitative genetics; Race

Indexed keywords

ANCESTRY GROUP; BIOLOGICAL MODEL; GENETIC VARIATION; HUMAN; PHENOTYPE; QUANTITATIVE TRAIT LOCUS;

CONTINENTAL POPULATION GROUPS; GENETIC VARIATION; HUMANS; MODELS, GENETIC; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 84938415837     PISSN: 13698486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.shpsc.2014.12.005     Document Type: Article

References (54)

1. Andreasen R.O. The cladistic race concept: A defense. Biology and Philosophy 2004, 19:425-442.
2. Bamshad M.J., Wooding S., Watkins W.S., Ostler C.T., Batzer M.A., Jorde L.B. Human population genetic structure and inference of group membership. American Journal of Human Genetics 2003, 72:578-589.
3. Barbujani G., Ghirotto S., Tassi F. Nine things to remember about human genome diversity. Tissue Antigens 2013, 82:155-164.
4. Barbujani G., Magagni A., Minch E., Cavalli-Sforza L.L. An apportionment of human DNA diversity. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:4516-4519.
5. Berg J.J., Coop G. Apopulation genetic signal of polygenic adaptation. PLoS Genetics 2014, 10:e1004412.
6. Bowcock A.M., Ruiz-Linares A., Tomfohrde J., Minch E., Kidd J.R., Cavalli-Sforza L.L. High resolution of human evolutionary trees with polymorphic microsatellites. Nature 1994, 368:455-457.
7. Brown R.A., Armelagos G.J. Apportionment of racial diversity: A review. Evolutionary Anthropology 2001, 10:34-40.
8. Chakraborty R., Nei M. Genetic differentiation of quantitative characters between populations or species: I. Mutation and random genetic drift. Genetical Research 1982, 39:303-314.
9. Cohen J. Statistical power analysis for the behavioral sciences 1988, Lawrence Erlbaum Associates, Hillsdale, New Jersey. 2nd ed.
10. Deheuvels P., Puri M.L., Ralescu S.S. Asymptotic expansions for sums of nonidentically distributed Bernoulli random variables. Journal of Multivariate Analysis 1989, 28:282-303.
11. Donovan B.M. Putting humanity back into the teaching of human biology. Studies in History and Philosophy of Biological and Biomedical Sciences 2015, 52:65-75.
12. Edwards A.W.F. Human genetic diversity: Lewontin's fallacy. Bioessays 2003, 25:798-801.
13. Feldman M.W., Lewontin R.C. Race, ancestry, and medicine. Revisiting race in a genomic age 2008, 89-101. Rutgers, Piscataway, New Jersey. B.A. Koenig, S.S.-J. Lee, S.S. Richardson (Eds.).
14. Felsenstein J. Maximum-likelihood estimation of evolutionary trees from continuous characters. American Journal of Human Genetics 1973, 25:471-492.
15. Felsenstein J. Population differences in quantitative characters and gene frequencies: A comment on papers by Lewontin and Rogers. American Naturalist 1986, 127:731-732.
16. Gannett L. Questions asked and unasked: How by worrying less about the 'really real' philosophers of science might better contribute to debates about genetics and race. Synthese 2010, 177:363-385.
17. Glasgow J.M. On the new biology of race. The Journal of Philosophy 2003, 100:456-474.
18. Goodman A.H. Why genes don't count (for racial differences in health). American Journal of Public Health 2000, 90:1699-1702.
19. Hardimon M.O. The idea of a scientific concept of race. Journal of Philosophical Research 2012, 37:249-282.
20. Hochman A. Against the new racial naturalism. The Journal of Philosophy 2013, 110:331-351.
21. Holsinger K.E., Weir B.S. Genetics in geographically structured populations: Defining, estimating and interpreting FST. Nature Reviews Genetics 2009, 10:639-650.
22. Kaplan J.M., Winther R.G. Realism, antirealism, and conventionalism about race. Philosophy of Science 2014, 81:1039-1052.
23. Kitcher P. Does 'race' have a future?. Philosophy & Public Affairs 2007, 35:293-317.
24. Kopec M. Clines, clusters, and clades in the race debate. Philosophy of Science 2015, (in press).
25. Lande R. Natural selection and random genetic drift in phenotypic evolution. Evolution 1976, 30:314-334.
26. Lande R. Neutral theory of quantitative genetic variance in an island model with local extinction and colonization. Evolution 1992, 46:381-389.
27. Leinonen T., McCairns R.J.S., O'Hara R.B., Merilä J. QST-FST comparisons: Evolutionary and ecological insights from genomic heterogeneity. Nature Reviews Genetics 2013, 14:179-190.
28. Lewontin R.C. The apportionment of human diversity. Evolutionary biology 1972, Vol. 6:381-398. Appleton-Century-Crofts, New York.
29. Li J.Z., Absher D.M., Tang H., Southwick A.M., Casto A.M., Ramachandran S., et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science 2008, 319:1100-1104.
30. Ludwig D. Against the new metaphysics of race. Philosophy of Science 2015, (in press).
31. Lynch M., Spitze K. Evolutionary genetics of Daphnia. Ecological genetics 1994, 109-128. Princeton University Press, Princeton. L. Real (Ed.).
32. Mahalanobis P.C. On the generalized distance in statistics. Proceedings of the National Institute of Sciences of India 1936, 2:49-55.
33. Mitton J.B. Genetic differentiation of races of man as judged by single-locus and multilocus analyses. The American Naturalist 1977, 111:203-212.
34. Mountain J.L., Cavalli-Sforza L.L. Multilocus genotypes, a tree of individuals, and human evolutionary history. American Journal of Human Genetics 1997, 61:705-718.
35. Neel J.V. The major ethnic groups: Diversity in the midst of similarity. American Naturalist 1981, 117:83-87.
36. Pujol B., Wilson A.J., Ross R.I.C., Pannell J.R. Are QST-FST comparisons for natural populations meaningful?. Molecular Ecology 2008, 17:4782-4785.
37. Relethford J.H. Apportionment of global human genetic diversity based on craniometrics and skin color. American Journal of Physical Anthropology 2002, 118:393-398.
38. Risch N., Burchard E., Ziv E., Tang H. Categorization of humans in biomedical research: Genes, race and disease. Genome Biology 2002, 3:1-12. (comment2007).
39. Rogers A.R., Harpending H.C. Population structure and quantitative characters. Genetics 1983, 105:985-1002.
40. Rosenberg N.A. Apopulation-genetic perspective on the similarities and differences among worldwide human populations. Human Biology 2011, 83:659-684.
41. Rosenberg N.A., Li L.M., Ward R., Pritchard J.K. Informativeness of genetic markers for inference of ancestry. American Journal of Human Genetics 2003, 73:1402-1422.
42. Rosenberg N.A., Pritchard J.K., Weber J.L., Cann H.M., Kidd K.K., Zhivotovsky L.A., et al. Genetic structure of human populations. Science 2002, 298:2381-2385.
43. Rosenberg N.A., Pritchard J.K., Weber J.L., Cann H.M., Kidd K.K., Zhivotovsky L.A., et al. Response to comment on "Genetic structure of human populations". Science 2003, 300:1877.
44. Samuels S.M. On the number of successes in independent trials. Annals of Mathematical Statistics 1965, 36:1272-1278.
45. Sesardic N. Race: A social destruction of a biological concept. Biology & Philosophy 2010, 25:143-162.
46. Smouse P.E., Spielman R.S., Park M.H. Multiple-locus allocation of individuals to groups as a function of the genetic variation within and differences among human populations. American Naturalist 1982, 119:445-460.
47. Spencer Q. Aradical solution to the race problem. Philosophy of Science 2014, 81:1025-1038.
48. Spencer Q. Philosophy of race meets population genetics. Studies in History and Philosophy of Biological and Biomedical Sciences 2015, 52:46-55.
49. Spitze K. Population structure in Daphnia obtusa: Quantitative genetic and allozymic variation. Genetics 1993, 135:367-374.
50. Tal O. The cumulative effect of genetic markers on classification performance: Insights from simple models. Journal of Theoretical Biology 2012, 293:206-218.
51. Tang H., Quertermous T., Rodriguez B., Kardia S.L.R., Zhu X., Brown A., et al. Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. American Journal of Human Genetics 2005, 76:268-275.
52. Whitlock M.C. Neutral additive genetic variance in a metapopulation. Genetical Research 1999, 74:215-221.
53. Whitlock M.C. Evolutionary inference from QST. Molecular Ecology 2008, 17:1885-1896.
54. Winther R.G. The genetic reification of 'race'? A story of two mathematical methods. Critical Philosophy of Race 2014, 2:204-223.