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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 17, 2015, Pages 3468-3475

Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space

(10) Ross, Audrey G a Benton, Bret M b Chin, Donovan a De Pascale, Gianfranco b Fuller, John b Leeds, Jennifer A b Reck, Folkert b Richie, Daryl L b Vo, Jason b LaMarche, Matthew J a

a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

b Norvartis Institute for BioMedical Research (United States)

Author keywords

Antibacterial; Antibiotic; Bacterial permeability; Chemical space; Dimer; DNA gyrase; Fluoroquinolone; Middle space

Indexed keywords

CIPROFLOXACIN; DIMER; DNA TOPOISOMERASE (ATP HYDROLYSING); ERYTHROMYCIN; MACROLIDE; QUINOLONE DERIVATIVE; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICOCHEMICAL MODEL; PRINCIPAL COMPONENT ANALYSIS; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; CHEMISTRY; METABOLISM; PERMEABILITY; SYNTHESIS;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CIPROFLOXACIN; DNA, BACTERIAL; PERMEABILITY;

EID: 84938404528 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.07.010 Document Type: Article

Times cited : (24)

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