Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats

Neuropharmacology

Volumn 99, Issue , 2015, Pages 51-66

  Mitsui, Katsukuni ^a   Niwa, Tomohiro ^a   Kawahara, Yuji ^a   Morimoto, Noriko ^a   Ohmoto, Kazuyuki ^a   Kato, Masashi ^a   Yamaura, Yoshiyuki ^a   Yoshimoto, Naoki ^a   Suna, Hideaki ^a   Katsumata, Seishi ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Neurosteroid; Noradrenaline; ONO 2952; Stress; Translocator protein 18 kDa

Indexed keywords

1 [1 [4 CHLORO 2 METHOXYPHENYL] 5 FLUORO 1,9 DIHYDROSPIRO[BETA CARBOLINE 4,10 CYCLOPROPAN] 2[3H] YL]ETHANONE; ACYLTRANSFERASE; ADENOSINE; AGENTS AFFECTING PROTEIN METABOLISM; ALOSETRON; AMINE OXIDASE (FLAVIN CONTAINING); ANDROGEN RECEPTOR; ANGIOTENSIN; BOMBESIN; BRADYKININ; CALCIUM CHANNEL; CANNABINOID; CB 34; CHOLECYSTOKININ; CHOLINESTERASE; DIAZEPAM; DOPAMINE; ENDOTHELIN; ESTROGEN; NEUROSTEROID; NORADRENALIN; OXIDOREDUCTASE; PEPTIDASE; PROSTAGLANDIN SYNTHASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RAMOSETRON; TRANSLOCATOR PROTEIN 18 KDA AGONIST; TRANSLOCATOR PROTEIN 18 KDA ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; CARRIER PROTEIN; CYCLOPROPANE DERIVATIVE; FUSED HETEROCYCLIC RINGS; ONO-2952; PSYCHOTROPIC AGENT; TSPO PROTEIN, HUMAN; TSPO PROTEIN, RAT;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTI STRESS EFFECT; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DEFECATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG SELECTIVITY; FEAR; HUMAN; HUMAN CELL; IMMOBILIZATION STRESS; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; RAT MODEL; AMYGDALA; ANIMAL; ANTAGONISTS AND INHIBITORS; AVOIDANCE BEHAVIOR; CATALEPSY; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; EXERCISE; HIPPOCAMPUS; MENTAL STRESS; METABOLISM; PRECLINICAL STUDY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; WISTAR RAT;

AMYGDALA; ANIMALS; AVOIDANCE LEARNING; CARRIER PROTEINS; CELL LINE, TUMOR; CYCLOPROPANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FREEZING REACTION, CATALEPTIC; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HIPPOCAMPUS; HUMANS; MALE; PSYCHOTROPIC DRUGS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GABA; RECEPTORS, GABA-A; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL;

EID: 84938389420     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.07.011     Document Type: Article

References (67)

1. R.R. Anholt, P.L. Pedersen, E.B. De Souza, and S.H. Snyder The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane J. Biol. Chem. 261 1986 576 583
2. M. Ansseau, R. von Frenckell, J.L. Cerfontaine, and P. Papart Pilot study of PK 11195, a selective ligand for the peripheral-type benzodiazepine binding sites, in inpatients with anxious or depressive symptomatology Pharmacopsychiatry 24 1991 8 12
3. M.L. Barbaccia, G. Roscetti, F. Bolacchi, A. Concas, M.C. Mostallino, R.H. Purdy, and G. Biggio Stress-induced increase in brain neuroactive steroids: antagonism by abecarnil Pharmacol. Biochem. Behav. 54 1996 205 210
4. D. Belelli, and J.J. Lambert Neurosteroids: endogenous regulators of the GABAA receptor Nat. Rev. Neurosci. 6 2005 565 575
5. J. Belmar, C. Cuellar, I. Llona, S. Arancibia, C. Kusch, L. Tapia-Arancibia, A. Pinter, and H. Pérez Allopregnanolone-induced modification of presynaptic basal and K+-induced [3H]-norepinephrine efflux from rat cortical slices during the estrous cycle Neuroendocrinology 68 1998 264 271
6. P. Belujon, and A.A. Grace Hippocampus, amygdala and stress: Interacting systems that affect susceptibility to addiction Ann. N Y. Acad. Sci. 1216 2011 114 121
7. M. Bialer, S.I. Johannessen, R.H. Levy, E. Perucca, T. Tomson, and H.S. White Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI) Epilepsy Res. 103 2013 2 30
8. M. Bicíková, J. Tallová, M. Hill, Z. Krausová, and R. Hampl Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder Neurochem. Res. 25 2000 1623 1627
9. P. Blier, and M. El Mansari Serotonin and beyond: therapeutics for major depression Philos. Trans. R. Soc. Lond. B. Biol. Sci. 368 1615 2013 20120536
10. B. Bonaz, and Y. Taché Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor Brain Res. 641 1994 21 28
11. C. Braestrup, and R.F. Squires Specific benzodiazepine receptors in rat brain characterized by high-affinity [3H]diazepam binding Proc. Natl. Acad. Sci. U. S. A. 74 1977 3805 3809
12. C. Cascio, R. Guarneri, D. Russo, G. De Leo, M. Guarneri, F. Piccoli, and P. Guarneri Pregnenolone sulfate, a naturally occurring excitotoxin involved in delayed retinal cell death J. Neurochem. 74 2000 2380 2391
13. F. Chauveau, H. Boutin, N. Van Camp, F. Dollé, and B. Tavitian Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers Eur. J. Nucl. Med. Mol. Imaging 35 2008 2304 2319
14. M.K. Chen, and T.R. Guilarte Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair Pharmacol. Ther. 118 2008 1 17
15. M. Cosenza-Nashat, M.L. Zhao, H.S. Suh, J. Morgan, R. Natividad, S. Morgello, and S.C. Lee Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain Neuropathol. Appl. Neurobiol. 35 2009 306 328
16. E. Costa, and A. Guidotti Diazepam binding inhibitor (DBI): a peptide with multiple biological actions Life Sci. 49 1991 325 344
17. E. Da Pozzo, B. Costa, and C. Martini Translocator protein (TSPO) and neurosteroids: implications in psychiatric disorders Curr. Mol. Med. 12 2012 426 442
18. M.J. Ebner, D.I. Corol, H. Havlíková, J.W. Honour, and J.P. Fry Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain Endocrinology 147 2006 179 190
19. C. Ferrarese, T. Mennini, N. Pecora, C. Pierpaoli, M. Frigo, C. Marzorati, M. Gobbi, A. Bizzi, A. Codegoni, S. Garattini, and L. Frattola Diazepam binding inhibitor (DBI) increases after acute stress in rat Neuropharmacology 30 1991 1445 1452
20. T. Funatsu, A. Takeuchi, T. Hirata, Y. Keto, S. Akuzawa, and M. Sasamata Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats Eur. J. Pharmacol. 573 2007 190 195
21. M. Gavish, I. Bachman, R. Shoukrun, Y. Katz, L. Veenman, G. Weisinger, and A. Weizman Enigma of the peripheral benzodiazepine receptor Pharmacol. Rev. 51 1999 629 650
22. S.J. Grant, Y.H. Huang, and D.E. Redmond Jr. Benzodiazepines attenuate single unit activity in the locus coeruleus Life Sci. 27 1980 2231 2236
23. Y. Guan, M. Tang, Z. Jiang, and T.L. Peeters Excitatory effects of motilin in the hippocampus on gastric motility in rats Brain Res. 984 2003 33 41
24. M. Hardwick, D. Fertikh, M. Culty, H. Li, B. Vidic, and V. Papadopoulos Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol Cancer Res. 59 1999 831 842
25. T. Hirata, Y. Keto, T. Funatsu, S. Akuzawa, and M. Sasamata Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome J. Pharmacol. Sci. 104 2007 263 273
26. Y. Ida, M. Tanaka, A. Tsuda, S. Tsujimaru, and N. Nagasaki Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats: antagonism by Ro 15-1788 Life Sci. 37 1985 2491 2498
27. K. Ishida-Tokuda, Y. Ohno, H. Sakamoto, T. Ishibashi, J. Wakabayashi, R. Tojima, T. Morita, and M. Nakamura Evaluation of perospirone (SM-9018), a novel serotonin-2 and dopamine-2 receptor antagonist, and other antipsychotics in the conditioned fear stress-induced freezing behavior model in rats Jpn. J. Pharmacol. 72 1996 119 126
28. M. Joëls, and T.Z. Baram The neuro-symphony of stress Nat. Rev. Neurosci. 10 2009 459 466
29. A. Kita, H. Kohayakawa, T. Kinoshita, Y. Ochi, K. Nakamichi, S. Kurumiya, K. Furukawa, and M. Oka Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand Br. J. Pharmacol. 142 2004 1059 1072
30. A. Kita, and K. Furukawa Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice Pharmacol. Biochem. Behav. 89 2008 171 178
31. S.H. Koslow, J.W. Maas, C.L. Bowden, J.M. Davis, I. Hanin, and J. Javaid CSF and urinary biogenic amines and metabolites in depression and mania. A controlled, univariate analysis Arch. Gen. Psychiatry 40 1983 999 1010
32. G. Le Fur, N. Vaucher, M.L. Perrier, A. Flamier, J. Benavides, C. Renault, M.C. Dubroeucq, C. Guérémy, and A. Uzan Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies Life Sci. 33 1983 449 457
33. M.D. Majewska Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance Prog. Neurobiol. 38 1992 379 395
34. P.J. Marangos, J. Patel, J.P. Boulenger, and R. Clark-Rosenberg Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864 Mol. Pharmacol. 22 1982 26 32
35. C.L. Melchior, and R.F. Ritzmann Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze Pharmacol. Biochem. Behav. 48 1994 893 897
36. A.G. Mensah-Nyagan, J.L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system Pharmacol. Rev. 51 1999 63 81
37. Z. Merali, S. Khan, D.S. Michaud, S.A. Shippy, and H. Anisman Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release Eur. J. Neurosci. 20 2004 229 239
38. D.A. Morilak, G. Barrera, D.J. Echevarria, A.S. Garcia, A. Hernandez, S. Ma, and C.O. Petre Role of brain norepinephrine in the behavioral response to stress Prog. Neuropsychopharmacol. Biol. Psychiatry 29 2005 1214 1224
39. B. Myers, and B. Greenwood-Van Meerveld Role of anxiety in the pathophysiology of irritable bowel syndrome: importance of the amygdala Front. Neurosci. 3 2009 1 10
40. H. Möhler GABAA receptor diversity and pharmacology Cell Tissue Res. 326 2006 505 516
41. C. Nothdurfter, R. Rupprecht, and G. Rammes Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO) Curr. Top. Med. Chem. 12 2012 360 370
42. V. Papadopoulos, M. Baraldi, T.R. Guilarte, T.B. Knudsen, J.J. Lacapère, P. Lindemann, M.D. Norenberg, D. Nutt, A. Weizman, M.R. Zhang, and M. Gavish Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function Trends Pharmacol. Sci. 27 2006 402 409
43. V. Papadopoulos, P. Guarneri, K.E. Kreuger, A. Guidotti, and E. Costa Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor Proc. Natl. Acad. Sci. U. S. A. 89 1992 5113 5117
44. M.C. Pardon, G.G. Gould, A. Garcia, L. Phillips, M.C. Cook, S.A. Miller, P.A. Mason, and D.A. Morilak Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral responses to stress: implications for susceptibility to stress-related neuropsychiatric disorders Neuroscience 115 2002 229 242
45. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates fourth ed. 1998 Academic Press
46. G. Pinna Targeting neurosteroidogenesis as therapy for PTSD Front. Pharmacol. 4 2014 166
47. A. Pinter, and J. Belmar In vitro progesterone effects on 3H-norepinephrine release from rat cerebral cortex slices Neuroreport 4 1993 1203 1206
48. R.H. Purdy, A.L. Morrow, P.H. Moore Jr., and S.M. Paul Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain Proc. Natl. Acad. Sci. U. S. A. 88 1991 4553 4557
49. S.S. Rao, R.A. Hatfield, J.M. Suls, and M.J. Chamberlain Psychological and physical stress induce differential effects on human colonic motility Am. J. Gastroenterol. 93 1998 985 990
50. A.M. Rasmusson, G. Pinna, P. Paliwal, D. Weisman, C. Gottschalk, D. Charney, J. Krystal, and A. Guidotti Decreased cerebrospinal fluid allopregnanolone levels in woman with posttraumatic stress disorder Biol. Psychiatry 60 2006 704 713
51. R. Rupprecht, S.V. Papadopoulo, G. Rammes, T.C. Baghai, J. Fan, N. Akula, G. Groyer, D. Adams, and M. Schumacher Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders Nat. Rev. Drug Discov. 9 2010 971 988
52. R. Rupprecht, G. Rammes, D. Eser, T.C. Baghai, C. Schüle, C. Nothdurfter, T. Troxler, C. Gentsch, H.O. Kalkman, F. Chaperon, V. Uzunov, K.H. McAllister, V. Bertaina-Anglade, C.D. La Rochelle, D. Tuerck, A. Floesser, B. Kiese, M. Schumacher, R. Landgraf, F. Holsboer, and K. Kucher Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects Science 325 2009 490 493
53. J. Sarkar, S. Wakefield, G. MacKenzie, S.J. Moss, and J. Maguire Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors J. Neurosci. 31 2011 18,198 18,210
54. M. Serra, P. Madau, M.F. Chessa, M. Caddeo, E. Sanna, G. Trapani, M. Franco, G. Liso, R.H. Purdy, M.L. Barbaccia, and G. Biggio 2-Phenyl-imidazo [1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats Br. J. Pharmacol. 127 1999 177 187
55. R.C. Spiller Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome Curr. Opin. Pharmacol. 11 2011 68 74
56. R. Stam, G. Croiset, L.M. Akkermans, and V.M. Wiegant Effects of novelty and conditioned fear on small intestinal and colonic motility and behaviour in the rat Physiol. Behav. 58 1995 803 809
57. A. Ströhle, A. Pasini, E. Romeo, B. Hermann, G. Spalletta, F. di Michele, F. Holsboer, and R. Rupprecht Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression J. Psychiatr. Res. 34 2000 183 186
58. R.D. Strous, R. Maayan, and A. Weizman The relevance of neurosteroids to clinical psychiatry: from the laboratory to the bedside Eur. Neuropsychopharmacol. 16 2006 155 169
59. K. Suda, H. Setoyama, M. Nanno, S. Matsumoto, and M. Kawai Involvement of parasympathetic pelvic efferent pathway in psychological stress-induced defecation World J. Gastroenterol. 19 2013 1200 1209
60. G.M. Sullivan, J.D. Coplan, J.M. Kent, and J.M. Gorman The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias Biol. Psychiatry 46 1999 1205 1218
61. W. Timmermans, H. Xiong, C.C. Hoogenraad, and H.J. Krugers Stress and excitatory synapses: from health to disease Neuroscience 248 2013 626 636
62. S.R. Torres, T.S. Fröde, G.M. Nardi, N. Vita, R. Reeb, P. Ferrara, R.M. Ribeiro-do-Valle, and R.C. Farges Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation Eur. J. Pharmacol. 408 2000 199 211
63. R.J. Valentino, and E. Van Bockstaele Convergent regulation of locus coeruleus activity as an adaptive response to stress Eur. J. Pharmacol. 583 2008 194 203
64. C.E. Weaver Jr., F.S. Wu, T.T. Gibbs, and D.H. Farb Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons Brain Res. 803 1998 129 136
65. M.L. Wong, M.A. Kling, P.J. Munson, S. Listwak, J. Licinio, P. Prolo, B. Karp, I.E. McCutcheon, T.D. Geracioti Jr., M.D. DeBellis, K.C. Rice, D.S. Goldstein, J.D. Veldhuis, G.P. Chrousos, E.H. Oldfield, S.M. McCann, and P.W. Gold Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone Proc. Natl. Acad. Sci. U. S. A. 97 2000 325 330
66. H.T. Zhang, Y. Huang, N.U. Suvarna, C. Deng, A.M. Crissman, A.T. Hopper, M. De Vivo, G.M. Rose, and J.M. O'Donnell Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats Psychopharmacol. Berl. 179 2005 613 619
67. P. Zheng Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance Prog. Neurobiol. 89 2009 134 152