Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3′-dATP

Biochemical Journal

Volumn 469, Issue 3, 2015, Pages 367-374

  Müller, Martina ^a   Deimling, Tobias ^a   Hopfner, Karl Peter ^a   Witte, Gregor ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Crystal structure; Cyclic di adenosine 5 monophosphate (c di Amp); Diadenylate cyclase (Dac) domain; Inhibition; Reaction mechanism

Indexed keywords

ADENYLATE CYCLASE; DEOXYADENOSINE TRIPHOSPHATE; DNA INTEGRITY SCANNING PROTEIN A; PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; CYCLIC AMP; LYASE;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; THERMOTOGA MARITIMA; AMINO ACID SEQUENCE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); DISA; THERMOTOGA MARITIMA;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CYCLIC AMP; MOLECULAR SEQUENCE DATA; PHOSPHORUS-OXYGEN LYASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; THERMOTOGA MARITIMA;

EID: 84938380707     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150373     Document Type: Article

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