Use of very-low-dose methadone and haloperidol for pain control in palliative care patients: Are the sigma-1 receptors involved?

Journal of Palliative Medicine

Volumn 18, Issue 8, 2015, Pages 660-

  Cobos, Enrique J ^a   Baeyens, José M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL; METHADONE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SIGMA 1 OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT;

ANTINOCICEPTION; CLINICAL PRACTICE; CONTROL; DRUG USE; GASTROINTESTINAL TRANSIT; HUMAN; LETTER; LOW DRUG DOSE; NONHUMAN; PAIN CONTROL; PALLIATIVE THERAPY; PATIENT CARE; ANALGESIA; FEMALE; MALE; PAIN; PROCEDURES;

ANALGESICS, OPIOID; FEMALE; HALOPERIDOL; HUMANS; MALE; METHADONE; MORPHINE; PAIN; PAIN MANAGEMENT; PALLIATIVE CARE;

EID: 84938378813     PISSN: 10966218     EISSN: 15577740     Source Type: Journal    
DOI: 10.1089/jpm.2015.0147     Document Type: Letter

References (7)

1. Salpeter SR, Buckley JS, Buckley NS, Bruera E. The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: A preliminary report. J Palliat Med 2015; 18: 114-119
2. Entrena JM, Cobos EJ, Nieto FR, et al. Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: Role of sigma-1 receptors. Psychopharmacology (Berl) 2009; 205: 21-33
3. Cobos EJ, del Pozo E, Baeyens JM. Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells. J Neurochem 2007; 102: 812-825
4. Ishiwata K, Oda K, Sakata M, et al. A feasibility study of [11C]SA4503-PET for evaluating sigma1 receptor occupancy by neuroleptics: The binding of haloperidol to sigma1 and dopamine D2-like receptors. Ann Nucl Med 2006; 20: 569-573
5. Rodríguez-Muñoz M, Sánchez-Blázquez P, Herrero-Labrador R, et al. The r1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control. Antioxid Redox Signal 2015; 22: 799-818
6. Vidal-Torres A, de la Puente B, Rocasalbas M, et al. Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects. Eur J Pharmacol 2013; 711: 63-72
7. Sánchez-Fernández C, Nieto FR, González-Cano R, et al. Potentiation of morphine-induced mechanical antinociception by r1 receptor inhibition: Role of peripheral r1 receptors. Neuropharmacology 2013; 70: 348-358