A new antibiotic with potent activity targets MscL

Journal of Antibiotics

Volumn 68, Issue 7, 2015, Pages 453-462

  Iscla, Irene ^a   Wray, Robin ^a   Blount, Paul ^a   Larkins Ford, Jonah ^b   Conery, Annie L ^b   Ausubel, Frederick M ^b   Ramu, Soumya ^c   Kavanagh, Angela ^c   Huang, Johnny X ^c   Blaskovich, Mark A ^c   Cooper, Matthew A ^c   Obregon Henao, Andres ^d   Orme, Ian ^d   Tjandra, Edwin S ^e   Stroeher, Uwe H ^f   Brown, Melissa H ^f   Macardle, Cindy ^f   Van Holst, Nick ^f   Ling Tong, Chee ^g   Slattery, Ashley D ^g   Gibson, Christopher T ^g   Raston, Colin L ^g   Boulos, Ramiz A ^g   more..

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d Veterinary Dentistry and Oral Surgery   (United States)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f FLINDERS UNIVERSITY   (Australia)

^g Institute for NanoScale Science and Technology   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ION CHANNEL; MECHANOSENSITIVE ION CHANNEL OF LARGE CONDUCTANCE; RAMIZOL; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ENZYME INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HEK293 CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ISOLATION AND PURIFICATION; MECHANOTRANSDUCTION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; CAENORHABDITIS ELEGANS; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; ION CHANNELS; MECHANOTRANSDUCTION, CELLULAR; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

EID: 84938358846     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2015.4     Document Type: Article

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