BODIPY-doped silica nanoparticles with reduced dye leakage and enhanced singlet oxygen generation

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Zhuyuan ^a   Hong, Xuehua ^b   Zong, Shenfei ^a   Tang, Changquan ^b   Cui, Yiping ^a   Zheng, Qingdong ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4,4-DIFLUORO-4-BORA-3A,4A-DIAZA-S-INDACENE; BORON DERIVATIVE; FLUORESCENT DYE; NANOCAPSULE; PHOTOSENSITIZING AGENT; SILICON DIOXIDE; SINGLET OXYGEN;

APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DIFFUSION; DRUG EFFECTS; HUMAN; MCF-7 CELL LINE; METABOLISM; NEOPLASMS, EXPERIMENTAL; PARTICLE SIZE; PATHOLOGY; PHOTOCHEMOTHERAPY; PROCEDURES; TUMOR CELL LINE; ULTRASTRUCTURE;

APOPTOSIS; BORON COMPOUNDS; CELL LINE, TUMOR; CELL SURVIVAL; DIFFUSION; FLUORESCENT DYES; HUMANS; MCF-7 CELLS; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; PARTICLE SIZE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SILICON DIOXIDE; SINGLET OXYGEN;

EID: 84938264244     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12602     Document Type: Article

References (28)

1. Bonnett, R. Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy. Chem. Soc. Rev. 24, 19-33 (1995).
2. Castano, A. P., Mroz, P. & Hamblin, M. R. Photodynamic therapy and anti-tumour immunity. Nature Reviews Cancer 6, 535-545 (2006).
3. Lovell, J. F., Liu, T. W. B., Chen, J. & Zheng, G. Activatable photosensitizers for imaging and therapy. Chem. Rev. 110, 2839-2857 (2010).
4. Huang, Z. A review of progress in clinical photodynamic therapy. Technol. Cancer Res. Treat. 4, 283-293 (2005).
5. Idris, N. M. et al. In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat. Med. 18, 1580-U1190 (2012).
6. Hayashi, K. et al. Photostable iodinated silica/porphyrin hybrid nanoparticles with heavy-atom effect for wide-field photodynamic/ photothermal therapy using single light source. Adv. Funct. Mater. 24, 503-513 (2014).
7. Gorman, A. et al. In vitro demonstration of the heavy-atom effect for photodynamic therapy. J. Am. Chem. Soc. 126, 10619-10631 (2004).
8. Chen, Y. H. et al. Bacteriopurpurinimides: Highly stable and potent photosensitizers for photodynamic therapy. J. Med. Chem. 45, 255-258 (2002).
9. Mitzel, F., FitzGerald, S., Beeby, A. & Faust, R. Octaalkynyltetra 6,7 quinoxalinoporphyrazines: a new class of photosensitisers with potential for photodynamic therapy. Chem. Commun., 2596-2597 (2001).
10. Sternberg, E. D., Dolphin, D. & Bruckner, C. Porphyrin-based photosensitizers for use in photodynamic therapy. Tetrahedron 54, 4151-4202 (1998).
11. Lukyanets, E. A. Phthalocyanines as photosensitizers in the photodynamic therapy of cancer. J. Porphyrins Phthalocyanines 3, 424-432 (1999).
12. Cui, G. & Fang, W.-H. State-specific heavy-atom effect on intersystem crossing processes in 2-thiothymine: A potential photodynamic therapy photosensitizer. J. Chem. Phys. 138 (2013).
13. Kim, S. et al. Organically modified silica nanoparticles with intraparticle heavy-atom effect on the encapsulated photosensitizer for enhanced efficacy of photodynamic therapy. J. Phys. Chem. C 113, 12641-12644 (2009).
14. Liu, H.-Y. et al. Heavy-atom effect of corrole photosensitizer for photodynamic therapy. Chem. J. Chinese U.-Chinese 27, 1363-1365 (2006).
15. Zou, H., Wu, S. & Shen, J. Polymer/silica nanocomposites: Preparation, characterization, properties, and applications. Chem. Rev. 108, 3893-3957 (2008).
16. Beck, J. S. et al. A new family of mesoporous molecular-sieves prepared with liguid-crystal templates. J. Am. Chem. Soc. 114, 10834-10843 (1992).
17. Slowing, I. I., Trewyn, B. G., Giri, S. & Lin, V. S. Y. Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv. Funct. Mater. 17, 1225-1236 (2007).
18. Lee, C.-H. et al. Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv. Funct. Mater. 19, 215-222 (2009).
19. Kim, J. et al. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew. Chem. Int. Edit. 47, 8438-8441 (2008).
20. Huang, C.-C. et al. Enhancing transversal relaxation for magnetite nanoparticles in MR imaging using Gd3+-chelated mesoporous silica shells. Acs Nano 5, 3905-3916 (2011).
21. Mekawy, M. M., Yamaguchi, A., El-Safty, S. A., Itoh, T. & Teramae, N. Mesoporous silica hybrid membranes for precise size-exclusive separation of silver nanoparticles. J. Colloid Interface Sci. 355, 348-358 (2011).
22. Moorthy, M. S., Seo, D.-J., Song, H.-J., Park, S. S. & Ha, C.-S. Magnetic mesoporous silica hybrid nanoparticles for highly selective boron adsorption. J. Mater. Chem. A 1, 12485-12496 (2013).
23. Loudet, A. & Burgess, K. BODIPY dyes and their derivatives: Syntheses and spectroscopic properties. Chem. Rev. 107, 4891-4932 (2007).
24. Hong, X. et al. Silylated BODIPY dyes and their use in dye-encapsulated silica nanoparticles with switchable emitting wavelengths for cellular imaging. Analyst 137, 4140-4149 (2012).
25. Zheng, Q., Xu, G. & Prasad, P. N. Conformationally restricted dipyrromethene boron difluoride (BODIPY) dyes: Highly fluorescent, multicolored probes for cellular imaging. Chem. Eur. J. 14, 5812-5819 (2008).
26. Zhu, S. et al. Highly water-soluble neutral BODIPY dyes with controllable fluorescence quantum yields. Org. Lett. 13, 438-441 (2011).
27. Meng, G., Velayudham, S., Smith, A., Luck, R. & Liu, H. Color Tuning of Polyfluorene Emission with BODIPY Monomers. Macromolecules 42, 1995-2001 (2009).
28. Chong, H. et al. Conjugated polymer nanoparticles for light-activated anticancer and antibacterial activity with imaging capability. Langmuir 28, 2091-2098 (2012).