Eml4-alk-positive lung adenocarcinoma with signet-ring cells

Diagnostic Cytopathology

Volumn 42, Issue 5, 2014, Pages 460-463

  Kawahara, Akihiko ^a   Akiba, Jun ^b   Abe, Hideyuki ^a   Yamaguchi, Tomohiko ^a   Taira, Tomoki ^a   Azuma, Koichi ^b   Kage, Masayoshi ^a  

^a KURUME UNIVERSITY HOSPITAL   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; EML4-ALK FUSION PROTEIN, HUMAN; ONCOPROTEIN;

AGED; BRONCHIAL BRUSHING CYTOLOGY; BRONCHUS BIOPSY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CYTODIAGNOSIS; EML4 ALK GENE; FEMALE; GENE FUSION; GENE REARRANGEMENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG LOBECTOMY; LUNG NODULE; LUNG NON SMALL CELL CANCER; NOTE; PRIORITY JOURNAL; ADENOCARCINOMA; BIOSYNTHESIS; CARCINOMA, SIGNET RING CELL; GENE EXPRESSION; GENETICS; LUNG NEOPLASMS; PATHOLOGY;

ADENOCARCINOMA; AGED; CARCINOMA, SIGNET RING CELL; FEMALE; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; MUCINS; ONCOGENE PROTEINS, FUSION;

EID: 84899455556     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.22936     Document Type: Note

References (15)

1. Devesa SS, Bray FI, Vizcaino AP, Parkin DM,. International lung cancer trends by histologic type: Male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer 2005; 117: 294-299.
2. Parkin DM, Bray FI, Devasa SS,. Cancer burden in the year 2000: The global picture. Eur J Cancer 2001; 37: S4-S66.
3. Ohta Y, Shimizu Y, Matsumoto I, Tamura M, Oda M, Watanabe G,. Retrospective review of lung cancer patients with pleural dissemination after limited operations combined with parietal pleurectomy. JSurg Oncol 2005; 91: 237-242.
4. Paik JH, Choi CM, Kim H, et al. Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: A proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma. Lung Cancer 2012;76:403 - 409.
5. Yi ES, Boland JM, Maleszewski JJ, et al. Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH. J Thorac Oncol 2011; 6: 459-465.
6. McLeer-Florin A, Moro-Sibilot D, Melis A, et al. Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: A French study. J Thorac Oncol 2012; 7: 348-354.
7. Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol 2009; 22: 508-515.
8. Zhang X, Zhang S, Yang X, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer 2010; 9: 188-200.
9. Yoshida A, Tsuta K, Watanabe S, et al. Frequent ALK rearrangement and TTF-1/p63 co-expression in lung adenocarcinoma with signet-ring cell component. Lung Cancer 2011; 72: 309-315.
10. Jokoji R, Yamasaki T, Minami S, et al. Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma. J Clin Pathol 2010; 63: 1066-1070.
11. Ohba T, Sugio K, Kometani T, et al. Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: A case report. Lung Cancer 2011; 73: 375-378.
12. Tsuta K, Shibuki Y, Maezawa N, et al. Cytological features of signet-ring cell carcinoma of the lung: Comparison with the goblet-cell-type adenocarcinoma of the lung. Diagn Cytopathol 2009; 37: 159-163.
13. Nakamura M, Motosugi U, Shimizu Y, et al. Primary signet-ring cell carcinoma of the lung: A report of 2 cases. Acta Cytol 2010; 54: 771-774.
14. Sakai Y, Ohbayashi C, Satouchi M, Negoro S, Yoshimura M,. Bronchial brushing cytology of primary signet-ring adenocarcinoma of the lung. Another morphological feature on the Papanicolaou smear: A report of two cases. Diagn Cytopathol 2011; 39: 73-76.
15. Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009; 15: 5216-5223.