Management of immune-mediated cytopenias in pregnancy

Autoimmunity Reviews

Volumn 14, Issue 9, 2015, Pages 806-811

  Piatek, Caroline I ^a   El Hemaidi, Ihab ^b   Feinstein, Donald I ^a   Liebman, Howard A ^a   Akhtari, Mojtaba ^a  

^a USC UNIVERSITY HOSPITAL   (United States)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

Author keywords

Autoimmune hemolytic anemia; Autoimmune neutropenia; Immune thrombocytopenia; Pregnancy; Thrombotic thrombocytopenia purpura

Indexed keywords

CORTICOSTEROID; CYTOTOXIC AGENT; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNE NEUTROPENIA; CYTOPENIA; DELIVERY; FEMALE; HUMAN; IMMUNE MEDIATED CYTOPENIA; IMMUNE THROMBOCYTOPENIA; NEUTROPENIA; PLASMAPHERESIS; PREGNANCY; REVIEW; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; COMPLICATION; IMMUNOLOGY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; RECURRENT DISEASE;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RECURRENCE; THROMBOCYTOPENIA;

EID: 84938216455     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2015.05.003     Document Type: Review

References (70)

1. Østensen M., Villiger P.M., Förger F. Interaction of pregnancy and autoimmune rheumatic disease. Autoimmun Rev 2012, 11(6-7):A437-A446.
2. Carvalheiras G., Faria R., Braga J., Vasconcelos C. Fetal outcome in autoimmune diseases. Autoimmun Rev 2012, 11(6-7):A520-A530.
3. de Man Y.A., Dolhain R.J., van de Geijn F.E., Willemsen S.P., Hazes J.M. Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum 2008, 59(9):1241-1248.
4. Yang H., Liu H., Xu D., Zhao L., Wang Q., Leng X., et al. Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares-a case control study. PLoS One Aug 13 2014, 9(8):e104375.
5. Sanghavi M., Rutherford J.D. Cardiovascular physiology of pregnancy. Circulation 2014, 130(12):1003-1008.
6. Townsley D.M. Hematologic complications of pregnancy. Semin Hematol 2013, 50(3):222-231.
7. Sainio S., Kekomäki R., Riikonen S., Teramo K. Maternal thrombocytopenia at term: a population-based study. Acta Obstet Gynecol Scand 2000, 79(9):744-749.
8. Nisha S., Amita D., Uma S., Tripathi A.K., Pushplata S. Prevalence and characterization of thrombocytopenia in pregnancy in Indian women. Indian J Hematol Blood Transfus 2012, 28(2):77-81.
9. Loustau V., Debouverie O., Canoui-Poitrine F., Baili L., Khellaf M., Touboul C., et al. Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women. Br J Haematol 2014, 166(6):929-935.
10. Bremme K.A. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 2003, 16(2):153-168.
11. George J.N. The association of pregnancy with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Curr Opin Hematol 2003, 10(5):339-344.
12. Neunert C., Lim W., Crowther M., Cohen A., Solberg L., Crowther M. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood 2011, 117(16):4190-4207.
13. Gill K.K., Kelton J.G. Management of idiopathic thrombocytopenic purpura in pregnancy. Semin Hematol 2000, 37(3):275-289.
14. Newman K., Owlia M.B., El-Hemaidi I., Akhtari M. Management of immune cytopenias in patients with systemic lupus erythematosus-old and new. Autoimmun Rev 2013, 12(7):784-791.
15. Lo E., Deane S. Diagnosis and classification of immune-mediated thrombocytopenia. Autoimmun Rev 2014, 13(4-5):577-583.
16. Won Y.W., Moon W., Yun Y.S., Oh H.S., Choi J.H., Lee Y.Y., et al. Clinical aspects of pregnancy and delivery in patients with chronic idiopathic thrombocytopenic purpura (ITP). Korean J Intern Med 2005, 20(2):129-134.
17. Gernsheimer T., James A.H., Stasi R. How I treat thrombocytopenia in pregnancy. Blood 2013, 121(1):38-47.
18. Christiaens G.C., Nieuwenhuis H.K., von dem Borne A.E., Ouwehand W.H., Helmerhorst F.M., van Dalen C.M., et al. Idiopathic thrombocytopenic purpura in pregnancy: a randomized trial on the effect of antenatal low dose corticosteroids on neonatal platelet count. Br J Obstet Gynaecol 1990, 97(10):893-898.
19. Yildirim Y., Tinar S., Oner R.S., Kaya B., Toz E. Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy. J Perinat Med 2006, 34(4):280-284.
20. Laskin C.A., Bombardier C., Hannah M.E., Mandel F.P., Knox Richie J.W., Farewell V., et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 1997, 337(3):148-153.
21. Clark A.L. Clinical uses of intravenous immunoglobulin in pregnancy. Clin Obstet Gynecol 1999, 42(2):368-380.
22. Michel M., Novoa M.V., Bussel J.B. Intravenous anti-D as a treatment for immune thrombocytopenic purpura (ITP) during pregnancy. Br J Haematol 2003, 123(1):142-146.
23. Alkaabi J.K., Alkindi S., Riyami N.A., Zia F., Balla L.M., Balla S.M. Successful treatment of severe thrombocytopenia with romiplostim in a pregnant patient with systemic lupus erythematosus. Lupus 2012, 21(14):1571-1574.
24. Decroocq J., Marcellin L., Le Ray C., Willems L. Rescue therapy with romiplostim for refractory primary immune thrombocytopenia during pregnancy. Obstet Gynecol 2014, 124(2 Pt 2 Suppl. 1):481-483.
25. Patil A.S., Dotters-Katz S.K., Metjian A.D., James A.H., Swamy G.K. Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy. Obstet Gynecol 2013, 122(2 Pt 2):483-485.
26. Chakravarty E.F., Murray E.R., Kelman A., Farmer P. Pregnancy outcomes after maternal exposure to rituximab. Blood 2011, 117(5):1499-1506.
27. Bachanova V., Connors J.M. How is Hodgkin lymphoma in pregnancy best treated? ASH evidence-based review 2008. Hematol Am Soc Hematol Educ Program 2008, 33-34.
28. Mozaffari S., Abdolghaffari A., Nikfar S., Abdollahi M. Pregnancy outcomes in women with inflammatory bowel disease following exposure to thiopurines and antitumor necrosis factor drugs: a systematic review with meta-analysis. Hum Exp Toxicol 2015, 34(5):445-459.
29. Felbinger T.W., Posner M., Eltzschig H.K., Kodali B.S. Laparoscopic splenectomy in a pregnant patient with immune thrombocytopenic purpura. Int J Obstet Anesth 2007, 16(3):281-283.
30. Griffiths J., Sia W., Shapiro A.M., Tataryn I., Turner A.R. Laparoscopic splenectomy for the treatment of refractory immune thrombocytopenia in pregnancy. J Obstet Gynaecol Can 2005, 27(8):771-774.
31. Neunert C., Noroozi N., Norman G., Buchanan G.R., Goy J., Nazi I., et al. Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review. J Thromb Haemost 2015, 13(3):457-464.
32. Veneri D., Franchini M., Raffaelli R., Musola M., Memmo A., Franchi M., et al. Idiopathic thrombocytopenic purpura in pregnancy: analysis of 43 consecutive cases followed at a single Italian institution. Ann Hematol 2006, 85(8):552-554.
33. Webert K.E., Mittal R., Sigouin C., Heddle N.M., Kelton J.G. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura. Blood 2003, 102(13):4306-4311.
34. Fujita A., Sakai R., Matsuura S., Yamamoto W., Ohshima R., Kuwabara H., et al. A retrospective analysis of obstetric patients with idiopathic thrombocytopenic purpura: a single center study. Int J Hematol 2010, 92(3):463-467.
35. Yuce T., Acar D., Kalafat E., Alkilic A., Cetindag E., Soylemez F. Thrombocytopenia in pregnancy: do the time of diagnosis and delivery route affect pregnancy outcome in parturients with idiopathic thrombocytopenic purpura?. Int J Hematol 2014, 100(6):540-544.
36. Provan D., Stasi R., Newland A.C., Blanchette V.S., Bolton-Maggs P., Bussel J.B., et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010, 115(2):168-186.
37. Koyama S., Tomimatsu T., Kanagawa T., Kumasawa K., Tsutsui T., Kimura T. Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura. Am J Hematol 2012, 87(1):15-21.
38. van Veen J.J., Nokes T.J., Makris M. The risk of spinal haematoma following neuraxial anaesthesia or lumbar puncture in thrombocytopenic individuals. Br J Haematol 2010, 148(1):15-25.
39. Payne S.D., Resnik R., Moore T.R., Hedriana H.L., Kelly T.F. Maternal characteristics and risk of severe neonatal thrombocytopenia and intracranial hemorrhage in pregnancies complicated by autoimmune thrombocytopenia. Am J Obstet Gynecol 1997, 177(1):149-155.
40. Rayment R., Brunskill S.J., Soothill P.W., Roberts D.J., Bussel J.B., Murphy M.F. Antenatal interventions for fetomaternal alloimmune thrombocytopenia. Cochrane Database Syst Rev 2011, 5:CD004226.
41. Shenkman B., Einav Y. Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: diagnosis and classification. Autoimmun Rev 2014, 13(4-5):584-586.
42. Scully M., Hunt B.J., Benjamin S., Liesner R., Rose P., Peyvandi F., et al. British Committee for Standards in Haematology. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol 2012, 158(3):323-335.
43. Moatti-Cohen M., Garrec C., Wolf M., Boisseau P., Galicier L., Azoulay E., et al. French Reference Center for Thrombotic Microangiopathies. Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura. Blood 2012, 119(24):5888-5897.
44. Fujimura Y., Matsumoto M., Kokame K., Isonishi A., Soejima K., Akiyama N., et al. Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients. Br J Haematol 2009, 144(5):742-754.
45. Scully M., Thomas M., Underwood M., Watson H., Langley K., Camilleri R.S., et al. Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes. Blood 2014, 124(2):211-219.
46. Jiang Y., McIntosh J.J., Reese J.A., Deford C.C., Kremer Hovinga J.A., Lämmle B., et al. Pregnancy outcomes following recovery from acquired thrombotic thrombocytopenic purpura. Blood 2014, 123(11):1674-1680.
47. Ducloy-Bouthors A.S., Caron C., Subtil D., Provot F., Tournoys A., Wibau B., et al. Thrombotic thrombocytopenic purpura: medical and biological monitoring of six pregnancies. Eur J Obstet Gynecol Reprod Biol 2003, 111(2):146-152.
48. Bass G.F., Tuscano E.T., Tuscano J.M. Diagnosis and classification of autoimmune hemolytic anemia. Autoimmun Rev 2014, 13(4-5):560-564.
49. Barcellini W., Fattizzo B., Zaninoni A., Radice T., Nichele I., Di Bona E., et al. Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients. Blood 2014, 124(19):2930-2936.
50. Sokol R.J., Hewitt S., Stamps B.K. Erythrocyte autoantibodies, autoimmune haemolysis and pregnancy. Vox Sang 1982, 43(4):169-176.
51. Ng S.C., Wong K.K., Raman S., Bosco J. Autoimmune haemolytic anaemia in pregnancy: a case report. Eur J Obstet Gynecol Reprod Biol 1990, 37(1):83-85.
52. Agapidou A., Vlachaki E., Theodoridis T., Economou M., Perifanis V. Cyclosporine therapy during pregnancy in a patient with β-thalassemia major and autoimmune haemolytic anemia: a case report and review of the literature. Hippokratia 2013, 17(1):85-87.
53. Dhingra S., Wiener J.J., Jackson H. Management of cold agglutinin immune hemolytic anemia in pregnancy. Obstet Gynecol 2007, 110(2 Pt 2):485-486.
54. Batalias L., Trakakis E., Loghis C., Salabasis C., Simeonidis G., Karanikolopoulos P., et al. Autoimmune hemolytic anemia caused by cold agglutinins in a young pregnant woman. J Matern Fetal Neonatal Med 2006, 19(4):251-253.
55. Lefkou E., Nelson-Piercy C., Hunt B.J. Evans' syndrome in pregnancy: a systematic literature review and two new cases. Eur J Obstet Gynecol Reprod Biol 2010, 149(1):10-17.
56. Grigoriadis C., Tympa A., Liapis A., Hassiakos D., Bakas P. Alpha-methyldopa-induced autoimmune hemolytic anemia in the third trimester of pregnancy. Case Rep Obstet Gynecol 2013, 2013:150278. [Epub 2013 Sep 23]. 10.1155/2013/150278.
57. Benraad C.E., Scheerder H.A., Overbeeke M.A. Autoimmune haemolytic anaemia during pregnancy. Eur J Obstet Gynecol Reprod Biol 1994, 55(3):209-211.
58. Kumar R., Advani A.R., Sharan J., Basharutallah M.S., Al-Lumai A.S. Pregnancy induced hemolytic anemia: an unexplained entity. Ann Hematol 2001, 80(10):623-626.
59. Katsuragi S., Sameshima H., Omine M., Ikenoue T. Pregnancy-induced hemolytic anemia with a possible immune-related mechanism. Obstet Gynecol 2008, 111(2 Pt 2):528-529.
60. Garratty G., Leger R.M., Arndt P.A. Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures. Am J Obstet Gynecol 1999, 181:103.
61. Berentsen S. How I, manage cold agglutinin disease. Br J Haematol 2011, 153(3):309-317.
62. Ramasethu J., Luban N.C. Chapter 54. Alloimmune hemolytic disease of the fetus and newborn. Williams hematology 2010, 8e. McGraw-Hill, New York, NY. M.A. Lichtman, T.J. Kipps, U. Seligsohn, K. Kaushansky, J.T. Prchal, M.A. Lichtman, T.J. Kipps, U. Seligsohn, K. Kaushansky, J.T. Prchal (Eds.).
63. Ojeda-Uribe M., Gilliot C., Jung G., Drenou B., Brunot A. Administration of rituximab during the first trimester of pregnancy without consequences for the newborn. J Perinatol 2006, 26:252-255.
64. Hendrick A.M. Auto-immune haemolytic anaemia: a high-risk disorder for thromboembolism?. Hematology 2003, 8:53-56.
65. Newman K.A., Akhtari M. Management of autoimmune neutropenia in Felty's syndrome and systemic lupus erythematosus. Autoimmun Rev 2011, 10(7):432-437.
66. Akhtari M., Curtis B., Waller E.K. Autoimmune neutropenia in adults. Autoimmun Rev 2009, 9(1):62-66.
67. Kameoka J., Funato T., Miura T., Harigae H., Saito J., Yokoyama H., et al. Autoimmune neutropenia in pregnant women causing neonatal neutropenia. Br J Haematol 2001, 114(1):198-200.
68. Youinou P., Jamin C., Le Pottier L., Renaudineau Y., Hillion S., Pers J.O. Diagnostic criteria for autoimmune neutropenia. Autoimmun Rev 2014, 13(4-5):574-576.
69. Zeidler C., Grote U.A., Nickel A., Brand B., Carlsson G., Cortesão E., et al. Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry. Haematologica 2014, 99(8):1395-1402.
70. Boxer L.A., Bolyard A.A., Marrero T.M., Phan L., Bond J.M., Alter B.P., et al. Impact of G-CSF on outcomes of pregnancy in women with severe chronic neutropenia. Blood (ASH Annual Meeting Abstracts) 2011, [Abstract 4786].