The dose of levothyroxine in pregnant women with hypothyroidism should be increased by 20-30% in the first trimester

Danish Medical Journal

Volumn 61, Issue 12, 2014, Pages

  Hubaveshka, Julia ^a   Michaelsson, Luba Freja ^a   Nygaard, Birte ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; RADIOACTIVE IODINE; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; ASPHYXIA; CHEMILUMINESCENCE IMMUNOASSAY; DRUG DOSE INCREASE; ESOPHAGUS ATRESIA; FEMALE; FIRST TRIMESTER PREGNANCY; FOLLOW UP; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; PREECLAMPSIA; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; RETROSPECTIVE STUDY; SPONTANEOUS ABORTION; STILLBIRTH; THYROID FUNCTION TEST; THYROID SURGERY; BLOOD; CLINICAL TRIAL; DRUG EFFECTS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; REFERENCE VALUE;

ADULT; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, FIRST; REFERENCE VALUES; RETROSPECTIVE STUDIES; THYROID FUNCTION TESTS; THYROTROPIN; THYROXINE;

EID: 84938152713     PISSN: None     EISSN: 22451919     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Stagnaro-Green A, Abalovich M, Alexander E et al. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. The American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Thyroid 2011;21:1081-125.
2. Abalovich M, Amino N, Barbour LA et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endorinol Metab 2007;92(8 suppl): S1-S47.
3. Stagnaro-Green A. Overt hyperthyroidism and hypothyroidism during pregnancy. Clin Obstet Gynecol 2011;54:478-87.
4. Haddow JE, Palomaki GE, Allan WC et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999;341:549-55.
5. Casey BM, Leveno KJ. Thyroid disease in pregnancy. Obstet Gynecol 2006; 108:1283-92.
6. Verga U, Bergamaschi S, Cortelazzi D et al. Adjustment of L-T4 substitutive therapy in pregnant women with subclinical, overt or post-ablative hypothyroidism. Clin Endocrinol 2009;70:798-802.
7. Alexander EK, Marqusee E, Lawrence J et al. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med 2004;351:241-9.
8. Carle A, Laurberg P, Pedersen IB et al. Epidemiology of subtypes of hypothyroidism in Denmark. Eur J Endocrinol 2006;154:21-8.
9. Davis LE, Leveno K J, Cunningham, FG. Hypothyroidism complicating pregnancy. Obstet Gynecol 1988;72:108-12.
10. Leung AS, Millar LK, Koonings PP et al. Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol 1993;81:349-53.
11. Abalovich, M, Gutierrez S, Alcaraz, G et al. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 2002;12:63-8.
12. Haddow JE, Palomaki GE, Allan WC et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999;341:549-55.
13. Laurberg P, Andersen SL, Pedersen IB et al. Screening for overt thyroid disease in early pregnancy may be preferable to searching for small aberrations in thyroid function tests. Clin Endocrinol 2013;79:297-304.
14. Hallengren B, Lantz M, Andreasson B et al. Pregnant women on thyroxine substitution are often dysregulated in early pregnancy. Thyroid 2009;19: 391-4.
15. Taylor P, Minassian C, Rehman A et al. TSH levels and risk of miscarriage in woman on long-term Levothyroxine: a community based study. J Clin Endocrinol Metab 2014;10: 3895-902.
16. Granfors M, Åkerud H, Berglund A et al. Thyroid testing and management of hypothyroidism during pregnancy: a population based study. 2013:98:2684-92.