A genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer

Annals of Oncology

Volumn 26, Issue 6, 2015, Pages 1142-1148

  Lee, S Y ^a,b   Choi, Jin Eun ^a,b   Jeon, H S ^b   Hong, M J ^b   Choi, Y Y ^b   Kang, H G ^b   Yoo, S S ^a,b   Lee, E B ^b   Jeong, J Y ^b   Lee, W K ^b   Lee, J ^b   Cha, S I ^b   Kim, C H ^b   Kim, Y T ^c   Jheon, S ^c   Son, J W ^d   Park, J Y ^a,b,e  

^a Kyungpook National University School of Medicine   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Konyang University College of Medicine   (South Korea)

^e Kyungpook National University   (South Korea)

Author keywords

KRT81; miRNA target sites; Non small cell lung cancer; Polymorphisms

Indexed keywords

MICRORNA; 3' UNTRANSLATED REGION; KERATIN; KERATIN TYPE II; KRT81 PROTEIN, HUMAN; MESSENGER RNA;

ADULT; AGED; ALLELE; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DATA BASE; FEMALE; GENE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HIGH RISK PATIENT; HUMAN; KRT81 GENE; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT IDENTIFICATION; PRIORITY JOURNAL; REPLICATION STUDY; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; 3' UNTRANSLATED REGION; BINDING SITE; BIOLOGY; CARCINOMA, NON-SMALL-CELL LUNG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; KAPLAN MEIER METHOD; LUNG NEOPLASMS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PHENOTYPE; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; TIME FACTOR;

3' UNTRANSLATED REGIONS; AGED; BINDING SITES; CARCINOMA, NON-SMALL-CELL LUNG; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; KERATINS, HAIR-SPECIFIC; KERATINS, TYPE II; LUNG NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM STAGING; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TRANSFECTION;

EID: 84938095751     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdv100     Document Type: Article

References (23)

1. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006; 20: 515-524.
2. Griffiths-Jones S, Grocock RJ, van Dongen S et al. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006; 34:D140-D144.
3. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
4. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-269.
5. Fabbri M, Ivan M, Cimmino A et al. Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther 2007; 7: 1009-1019.
6. Guan P, Yin Z, Li X et al. Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res 2012; 31: 54.
7. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866.
8. Brennecke J, Stark A, Russell RB, Cohen SM. Principles of microRNA-target recognition. PLoS Biol 2005; 3: e85.
9. Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 2009; 10: 141-148.
10. Landi D, Gemignani F, Naccarati A et al. Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis 2008; 29: 579-584.
11. Chin LJ, Ratner E, Leng S et al. A SNP in a let-7 microRNA complementary site in the KRAS 30 untranslated region increases non-small-cell lung cancer risk. Cancer Res 2008; 68: 8535-8540.
12. Xu J, Yin Z, Gao W et al. Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population. PLoS One 2013; 8: e77024.
13. Teo MT, Landi D, Taylor CF et al. The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. Carcinogenesis 2012; 33: 581-586.
14. Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest 2009; 136: 260-271.
15. Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem Cell Biol 2008; 129: 705-733.
16. Magin TM, Vijayaraj P, Leube RE. Structural and regulatory functions of keratins. Exp Cell Res 2007; 313: 2021-2032.
17. Karantza V. Keratins in health and cancer: more than mere epithelial cell markers. Oncogene 2010; 30: 127-138.
18. Regnier CH, Boulay A, Asch PH et al. Expression of a truncated form of hHb1 hair keratin in human breast carcinomas. Br J Cancer 1998; 78: 1640-1644.
19. Campayo M, Navarro A, Vinolas N et al. A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma. PLoS One 2011; 6: e22509.
20. de Larrea CF, Navarro A, Tejero R et al. Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. Clin Cancer Res 2012; 18: 3697-3704.
21. Xie Y, Diao L, Zhang L et al. A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma. Gene 2014; 539: 198-202.
22. Pharoah PD, Dunning AM, Ponder BA, Easton DF. Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer 2004; 4: 850-860.
23. Chanock SJ, Manolio T, Boehnke M et al. Replicating genotype-phenotype associations. Nature 2007; 447:655-660.