Mycobacterial heat shock protein 65 (mbHSP65)-induced atherosclerosis: Preventive oral tolerization and definition of atheroprotective and atherogenic mbHSP65 peptides

Atherosclerosis

Volumn 242, Issue 1, 2015, Pages 303-310

  Grundtman, Cecilia ^a   Jakic, Bojana ^a   Buszko, Maja ^a   Onestingel, Elisabeth ^a   Almanzar, Giovanni ^a   Demetz, Egon ^a   Dietrich, Hermann ^a   Cappellano, Giuseppe ^a   Wick, Georg ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Atherosclerosis; Heat shock protein; Inflammation; Peptide; Treatment

Indexed keywords

AUTOANTIBODY; BACTERIUM ANTIBODY; CHAPERONIN 60; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; MESSENGER RNA; MYCOBACTERIAL HEAT SHOCK PROTEIN 65; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 ANTIBODY; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 20; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 33; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 34; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 61; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 67; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 68; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 84; MYCOBACTERIAL HEAT SHOCK PROTEIN 65 PEPTIDE 85; MYCOBACTERIUM VACCINE; PEPTIDE VACCINE; PROTEIN ANTIBODY; RECOMBINANT VACCINE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; APOLIPOPROTEIN E; BACTERIAL PROTEIN; CHOLESTEROL INTAKE; EPITOPE; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM; HSPD1 PROTEIN, MOUSE; IL10 PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; SUBUNIT VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENESIS; CELL PROLIFERATION ASSAY; CELL SPECIFICITY; CELLULAR IMMUNITY; CHOLESTEROL DIET; CONTROLLED STUDY; CROSS REACTION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL ATHEROSCLEROSIS; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IN VITRO STUDY; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; VACCINATION; ANIMAL; AORTIC DISEASES; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CELL PROLIFERATION; CHEMICALLY INDUCED; CHOLESTEROL INTAKE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; EPITOPE MAPPING; GENETICS; IMMUNIZATION; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPH NODE; LYMPHOCYTE ACTIVATION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; SPLEEN; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; AUTOANTIBODIES; BACTERIAL PROTEINS; CELL PROLIFERATION; CHAPERONIN 60; CHOLESTEROL, DIETARY; CROSS REACTIONS; DISEASE MODELS, ANIMAL; EPITOPE MAPPING; EPITOPES; FEMALE; IMMUNIZATION; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-10; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; SPLEEN; T-LYMPHOCYTES, REGULATORY; VACCINES, SUBUNIT;

EID: 84938066992     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.06.044     Document Type: Article

References (35)

1. Ross R., Glomset J.A. The pathogenesis of atherosclerosis (first of two parts). N.Engl. J. Med. 1976, 295:369-377.
2. Ross R., Glomset J.A. The pathogenesis of atherosclerosis (second of two parts). N.Engl. J. Med. 1976, 295:420-425.
3. Almanzar G., Öllinger R., Leuenberger J., Onestingel E., Rantner B., Zehm S., Cardini B., van der Zee R., Grundtman C., Wick G. Autoreactive HSP60 epitope-specific T cells in early human atherosclerotic lesions. J.Autoimmun. 2012, 39:441-450.
4. Xu Q., Dietrich H., Steiner H.J., Gown A.M., Schoel B., Mikuz G., Kaufmann S.H., Wick G. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler. Thromb. 1992, 12:789-799.
5. Afek A., George J., Gilburd B., Rauova L., Goldberg I., Kopolovic J., Harats D., Shoenfeld Y. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J.Autoimmun. 2000, 14:115-121.
6. Xu Q., Kleindienst R., Schett G., Waitz W., Jindal S., Gupta R.S., Dietrich H., Wick G. Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits. Atherosclerosis 1996, 123:145-155.
7. Wick G., Jakic B., Buszko M., Wick M.C., Grundtman C. The role of heat shock proteins in atherosclerosis. Nat. Rev. Cardiol. 2014, 11:516-529.
8. Young R.A., Elliott T.J. Stress proteins, infection, and immune surveillance. Cell 1989, 59:5-8.
9. Xu Q., Schett G., Seitz C.S., Hu Y., Gupta R.S., Wick G. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells. Circ. Res. 1994, 75:1078-1085.
10. Seitz C.S., Kleindienst R., Xu Q., Wick G. Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin. Lab. Invest. 1996, 74:241-252.
11. Mayr M., Metzler B., Kiechl S., Willeit J., Schett G., Xu Q., Wick G. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation 1999, 99:1560-1566.
12. Hochleitner B.W., Hochleitner E.O., Obrist P., Eberl T., Amberger A., Xu Q., Margreiter R., Wick G. Fluid shear stress induces heat shock protein 60 expression in endothelial cells invitro and invivo. Arterioscler. Thromb. Vasc. Biol. 2000, 20:617-623.
13. Pfister G., Stroh C.M., Perschinka H., Kind M., Knoflach M., Hinterdorfer P., Wick G. Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy. J.Cell Sci. 2005, 118:1587-1594.
14. Millonig G., Schwentner C., Mueller P., Mayerl C., Wick G. The vascular-associated lymphoid tissue: a new site of local immunity. Curr. Opin. Lipidol. 2001, 12:547-553.
15. Perschinka H., Mayr M., Millonig G., Mayerl C., van der Zee R., Morrison S.G., Morrison R.P., Xu Q., Wick G. Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2003, 23:1060-1065.
16. Harats D., Yacov N., Gilburd B., Shoenfeld Y., George J. Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J.Am. Coll. Cardiol. 2002, 40:1333-1338.
17. Wang P., Sidney J., Dow C., Mothé B., Sette A., Peters B. Asystematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput. Biol. 2008, 4(4):e1000048.
18. Grundtman C., Kreutmayer S.B., Almanzar G., Wick M.C., Wick G. Heat shock protein 60 and immune inflammatory responses in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2011, 31:960-968.
19. Wick G., Knoflach M., Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev. Immunol. 2004, 22:361-403.
20. Jing H., Yong L., Haiyan L., Yanjun M., Yun X., Yu Z., Taiming L., Rongyue C., Liang J., Jie W., Li Z., Jingjing L. Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice. Vaccine 2011, 31(29):4102-4109.
21. -/- mice. Immunobiology 2012, 217:540-547.
22. Xiong Q., Li J., Jin L., Liu J., Li T. Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms. Immunol. Lett. 2009, 125:40-45.
23. Maron R., Sukhova G., Faria A.M., Hoffmann E., Mach F., Libby P., Weiner H.L. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 2002, 106:1708-1715.
24. Leask A., Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB J. 2004, 18:816-827.
25. Mallat Z., Gojova A., Marchiol-Fournigault C., Esposito B., Kamaté C., Merval R., Fradelizi D., Tedgui A. Inhibition of transforming growth factor-β signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ. Res. 2001, 89:930-934.
26. Lutgens E., Gijbels M., Smook M., Heeringa P., Gotwals P., Koteliansky V.E., Daemen M.J. Transforming growth factor-β mediates balance between inflammation and fibrosis during plaque progression. Arterioscler. Thromb. Vasc. Biol. 2002, 22:975-982.
27. Grainger D.J., Kemp P.R., Metcalfe J.C., Liu A.C., Lawn R.M., Williams N.R., Grace A.A., Schofield P.M., Chauhan A. The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis. Nat. Med. 1995, 1:74-79.
28. Chen Y., Kuchroo V.K., Inobe J.L., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265:1237-1240.
29. Mayrl M., Kiechl S., Willeit J., Wick G., Xu Q. Infections, immunity, and atherosclerosis: association of antibodies to Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus with immune reactions to heat shock protein 60 and cartoid or femoral atherosclerosis. Circulation 2000, 102:833-839.
30. van Puijvelde G.H., van Es T., van Wanrooij E.J., Habets K.L., de Vos P., van der Zee R., van Eden W., van Berkel T.J., Kuiper J. Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2007, 27:2677-2683.
31. Thorstenson K.M., Khoruts A. Generation of anergic and potentially immunoregulatory CD25+CD4 T cells invivo after induction of peripheral tolerance with intravenous or oral antigen. J.Immunol. 2001, 167:188-195.
32. Zhang X., Izikson L., Liu L., Weiner H.L. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J.Immunol. 2001, 167:4245-4253.
33. Weiner H.L., da Cunha A.P., Quintana F., Wu H. Oral tolerance. Immunol. Rev. 2011, 241:241-259.
34. Hagerty D.T., Allen P.M. Intramolecular mimicry. Identification and analysis oftwo cross-reactive T cell epitopes within a single protein. J.Immunol. 1995, 155:2993-3001.
35. Choi J.I., Chung S.W., Kang H.S., Rhim B.Y., Park Y.M., Kim U.S., Kim S.J. Epitope mapping of Porphyromonas gingivalis heat-shock protein and human heat-shock protein in human atherosclerosis. J.Dent. Res. 2004, 83:936-940.