Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Molecular Biology Reports

Volumn 42, Issue 8, 2015, Pages 1289-1293

  Hubacek, J A ^a   Stanek V ^a   Gebauerova M ^a   Poledne, R ^a   Aschermann, M ^b   Skalicka H ^b   Matouskova J ^c   Kruger, A ^c   Penicka M ^d   Hrabakova H ^a,d   Veselka, J ^e   Hajek P ^e   Lanska V ^a   Adamkova V ^a   Pitha J ^a  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c NA HOMOLCE HOSPITAL   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

Author keywords

Acute coronary syndrome; MTHFD1L; Polymorphism; Slavonic population

Indexed keywords

CHOLESTEROL; FORMATE TETRAHYDROFOLATE LIGASE; FORMYL-METHENYL-METHYLENETETRAHYDROFOLATE SYNTHETASE; HYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MULTIENZYME COMPLEX;

ACUTE CORONARY SYNDROME; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CZECH (PEOPLE); DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FOLLOW UP; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MTHFD1L GENE; OBESITY; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; PREVALENCE; PROGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SEX DIFFERENCE; SMOKING; SURVIVAL RATE; ADULT; GENETICS; MIDDLE AGED; MORTALITY; MYOCARDIAL INFARCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE CORONARY SYNDROME; ADULT; AGED; AMINOHYDROLASES; FEMALE; FORMATE-TETRAHYDROFOLATE LIGASE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MIDDLE AGED; MULTIENZYME COMPLEXES; MYOCARDIAL INFARCTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84937979177     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-015-3870-1     Document Type: Article

References (23)

1. Hubacek JA, Stanek V, Gebauerova M, Pilipcincova A, Dlouha D, Poledne R et al (2010) A FTO variant and risk of acute coronary syndrome. Clin Chim Acta 411:1069–1072
2. Palomaki GE, Melillo S, Bradley LA (2010) Association between 9p21 genomic markers and heart disease: a meta-analysis. JAMA 303:648–656
3. Hubacek JA, Staněk V, Gebauerová M, Poledne R, Aschermann M, Skalicka H et al (2012) Association between a marker on chromosome 9 and acute coronary syndrome. Confirmatory study on Czech population. Folia Biol (Praha) 58:203–208
4. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B et al (2007) Genomewide association analysis of coronary artery disease. N Engl J Med 357:443–453
5. Saade S, Cazier JB, Ghassibe-Sabbagh M, Youhanna S, Badro DA, Kamatani Y et al (2011) FGENTCARD consortium. Large scale association analysis identifies three susceptibility loci for coronary artery disease. PLoS One 6:e29427
6. Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J et al (2012) Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J 33:393–407
7. Ghazouani L, Khalifa SB, Abboud N, Perret C, Nicaud V, Ben Khalfallah A et al (2010) Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population. J Thromb Thrombolysis 29:114–118
8. Wang AZ, Li L, Zhang B, Shen GQ, Wang QK (2011) Association of SNP rs17465637 on chromosome 1q41 and rs599839 on 1p13.3 with myocardial infarction in an American caucasian population. Ann Hum Genet 75:475–482
9. Hubacek JA, Staněk V, Gebauerová M, Pilipcincova A, Poledne R, Aschermann M et al (2010) Lack of an association between connexin-37, stromelysin-1, plasminogen activator-inhibitor type 1 and lymphotoxin-alpha genes and acute coronary syndrome in Czech Caucasians. Exp Clin Cardiol 15:e52–e56
10. Tunstall-Pedoe H, Kuulasmaa K, Tolonen H, Davidson M, Mendis S. MONICA monograph and multimedia sourcebook. (2003). Tunstal-Pedoe H, editor. Geneva: World Health Organisation. http://whqlibdoc.who.int/publication/2003/9241562234.pdf
11. Palmer BR, Slow S, Ellis KL, Pilbrow AP, Skelton L, Frampton CM et al (2014) Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival an baseline active vitamin B12 levels in post-acute coronary syndrome patients. PLos One 5:e89029
12. Morgan TM, House J, Cresci S, Jones P, Allayee H, Hazen SL et al (2011) Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Med Genet 12:127
13. Munafò MR (2009) Reliability and replicability of genetic association studies. Addiction 104:1439–1440
14. Hashad IM, Abdel Rahman MF, Abdel-Maksoud SM, Amr KS, Effat LK, Shaban GM et al (2014) C242T polymorphism of NADPHoxidase p22phox gene reduces the risk of coronary artery disease in a random sample of Egyptian population. Mol Biol Rep 41:2281–2286
15. Iqbal R, Jahan N, Sun Y, Xue H (2014) Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population. Mol Biol Rep 41:1545–1552
16. Franceschini N, Carty C, Bůzková P, Reiner AP, Garrett T, Lin Y et al (2011) Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. Circ Cardovasc Genet 4:661–672
17. Cunnington MS, Mayosi BM, Hall DH, Avery PJ, Farrall M, Vickers MA et al (2009) Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis 203:41–44
18. Muendlein A, Saely CH, Rhomberg S, Sonderegger G, Loacker S, Rein P et al (2009) Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Atherosclerosis 205:174–180
19. Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR et al (2008) Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40:149–151
20. Vrablik M, Ceska R, Adamkova V, Peasey A, Pikhart H, Kubinova R et al (2008) MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe. Hum Genet 124:553–555
21. Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF et al (2007) Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 16:24–35
22. Hubacek JA, Dlouha D, Lanska V, Adamkova V (2012) Lack of an association between three tagging SNPs within the FTO gene and smoking behavior. Nicotine Tob Res 14:998–1002
23. Nelis M, Esko T, Mägi R, Zimprich F, Zimprich A, Toncheva D et al (2009) Genetic structure of Europeans: a view from the North-East. PLoS One 4:e5472