Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Morgan, Thomas M ^a   House, John A ^b   Cresci, Sharon ^c   Jones, Philip ^b   Allayee, Hooman ^d   Hazen, Stanley L ^e   Patel, Yesha ^d   Patel, Riyaz S ^f,g   Eapen, Danny J ^f   Waddy, Salina P ^h   Quyyumi, Arshed A ^f   Kleber, Marcus E ^i,j   März, Winfried ^k,l   Winkelmann, Bernhard R ^m   Boehm, Bernhard O ^n,o   Krumholz, Harlan M ^d   Spertus, John A ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g CARDIFF UNIVERSITY   (United Kingdom)

^h NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

ⁱ LURIC non profit LLC   (Germany)

^j UNIVERSITY OF HEIDELBERG   (Germany)

^k MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^l Clinical Institute of Medical and Chemical Laboratory Diagnostics   (Austria)

^m Cardiology Group   (Germany)

ⁿ UNIVERSITY OF ULM   (Germany)

^o YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE CORONARY SYNDROME; ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; COHORT ANALYSIS; CORONARY ARTERY DISEASE; CORONARY RISK; FEMALE; GENETIC ASSOCIATION; GENOME; GENOTYPE; HAZARD RATIO; HEART INFARCTION; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROPORTIONAL HAZARDS MODEL; RACE DIFFERENCE; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; UNITED STATES; AGED; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; STATISTICS;

FORMATE TETRAHYDROFOLATE LIGASE; FORMYL METHENYL METHYLENETETRAHYDROFOLATE SYNTHETASE; FORMYL-METHENYL-METHYLENETETRAHYDROFOLATE SYNTHETASE; HYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MULTIENZYME COMPLEX;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; AMINOHYDROLASES; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FORMATE-TETRAHYDROFOLATE LIGASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MIDDLE AGED; MULTIENZYME COMPLEXES; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 80053175382     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-127     Document Type: Article

References (24)

1. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, et al. Finding the missing heritability of complex diseases. Nature 2009, 461(7265):747-753. 10.1038/nature08494, 2831613, 19812666.
2. Wellcome Trust Case Control Consortium Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 2007, 447(7145):661-678. 10.1038/nature05911, 2719288, 17554300, Wellcome Trust Case Control Consortium.
3. Dorn GW, Cresci S. Genome-wide association studies of coronary artery disease and heart failure: where are we going?. Pharmacogenomics 2009, 10(2):213-223. 10.2217/14622416.10.2.213, 19207022.
4. Erdmann J, Grosshennig A, Braund PS, Konig IR, Hengstenberg C, Hall AS, Linsel-Nitschke P, Kathiresan S, Wright B, Tregouet DA, et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009, 41(3):280-282. 10.1038/ng.307, 2695543, 19198612.
5. Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41(3):334-341. 10.1038/ng.327, 2681011, 19198609.
6. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008, 9(5):356-369. 10.1038/nrg2344, 18398418.
7. Morgan TM, Krumholz HM, Lifton RP, Spertus JA. Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. Jama 2007, 297(14):1551-1561. 10.1001/jama.297.14.1551, 17426274.
8. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000, 36(3):959-969. 10.1016/S0735-1097(00)00804-4, 10987628.
9. Braunwald E. Unstable angina. A classification. Circulation 1989, 80(2):410-414. 10.1161/01.CIR.80.2.410, 2752565.
10. Schisterman EF, Whitcomb BW. Use of the Social Security Administration Death Master File for ascertainment of mortality status. Popul Health Metr 2004, 2(1):2. 10.1186/1478-7954-2-2, 406423, 15003125.
11. Salisbury AC, Kosiborod M. Outcomes associated with anemia in patients with heart failure. Heart Fail Clin 6(3):359-372.
12. Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, et al. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA 2008, 299(11):1265-1276. 10.1001/jama.299.11.1265, 3014051, 18349088.
13. Nicholls SJ, Tang WH, Scoffone H, Brennan DM, Hartiala J, Allayee H, Hazen SL. Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. J Lipid Res 51(10):3055-3061.
14. Patel RS, Su S, Neeland IJ, Ahuja A, Veledar E, Zhao J, Helgadottir A, Holm H, Gulcher JR, Stefansson K, et al. The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J 31(24):3017-3023.
15. Winkelmann BR, Marz W, Boehm BO, Zotz R, Hager J, Hellstern P, Senges J. Rationale and design of the LURIC study--a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001, 2(1 Suppl 1):S1-73.
16. Dean FB, Hosono S, Fang L, Wu X, Faruqi AF, Bray-Ward P, Sun Z, Zong Q, Du Y, Du J, et al. Comprehensive human genome amplification using multiple displacement amplification. Proc Natl Acad Sci USA 2002, 99(8):5261-5266. 10.1073/pnas.082089499, 122757, 11959976.
17. Yan J, Feng J, Hosono S, Sommer SS. Assessment of multiple displacement amplification in molecular epidemiology. Biotechniques 2004, 37(1):136-138. 140-133.
18. Morgan TM, Xiao L, Lyons P, Kassebaum B, Krumholz HM, Spertus JA. Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome. BMC Med Genet 2008, 9:66. 2483267, 18620593.
19. Yuan A, Bonney GE. Exact test of Hardy-Weinberg equilibrium by Markov chain Monte Carlo. Math Med Biol 2003, 20(4):327-340. 10.1093/imammb/20.4.327, 14969383.
20. Perneger TV. What's wrong with Bonferroni adjustments. Bmj 1998, 316(7139):1236-1238. 1112991, 9553006.
21. Dupont WD, Plummer WD. Power and sample size calculations for studies involving linear regression. Controlled clinical trials 1998, 19(6):589-601. 10.1016/S0197-2456(98)00037-3, 9875838.
22. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, et al. Genomewide association analysis of coronary artery disease. The New England journal of medicine 2007, 357(5):443-453. 10.1056/NEJMoa072366, 2719290, 17634449.
23. Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43(4):333-338.
24. Muendlein A, Saely CH, Rhomberg S, Sonderegger G, Loacker S, Rein P, Beer S, Vonbank A, Winder T, Drexel H. Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Atherosclerosis 2009, 205(1):174-180. 10.1016/j.atherosclerosis.2008.10.035, 19135198.