Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4364-4374

  Wang, Lei ^a   Hou, Xuben ^a   Fu, Huansheng ^a   Pan, Xiaole ^a   Xu, Wenfang ^a   Tang, Weiping ^b   Fang, Hao ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anti proliferative; HDAC; Hydroxamic acid; Inhibitor; Quinoline

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; N1 HYDROXY N5 (QUINOLIN 2 YLMETHYL)GLUTARAMIDE; N1 HYDROXY N6 (QUINOLIN 2 YLMETHYL)ADIPAMIDE; N1 HYDROXY N7 (QUINOLIN 2 YLMETHYL)HEPTANEDIAMIDE; N1 HYDROXY N7 [[4 (METHYLCARBAMOYL)QUINOLIN 2 YL]METHYL]HEPTANEDIAMIDE; N1 HYDROXY N7 [[4 (PHENYLCARBAMOYL)QUINOLIN 2 YL]METHYL]HEPTANEDIAMIDE; N1 HYDROXY N8 (QUINOLIN 2 YLMETHYL)OCTANEDIAMIDE; N1 HYDROXY N8 [[4 (METHYLCARBAMOYL)QUINOLIN 2 YL]METHYL]OCTANEDIAMIDE; N1 HYDROXY N8 [[4 (PHENYLCARBAMOYL)QUINOLIN 2 YL]METHYL]OCTANEDIAMIDE; N1 [(6 BROMOQUINOLIN 2 YL)METHYL] N7 HYDROXYHEPTANE DIAMIDE; N1 [(6 BROMOQUINOLIN 2 YL)METHYL] N8 HYDROXYOCTANE DIAMIDE; N1 [(6 CHLOROQUINOLIN 2 YL)METHYL] N7 HYDROXYHEPTANE DIAMIDE; N1 [(6 FLUOROQUINOLIN 2 YL)METHYL] N7 HYDROXYHEPTANE DIAMIDE; N1 [[4 (BENZYLCARBAMOYL) 6 BROMOQUINOLIN 2 YL]METHYL] N7 HYDROXYHEPTANEDIAMIDE; N1 [[4 (BENZYLCARBAMOYL) 6 BROMOQUINOLIN 2 YL]METHYL] N8 HYDROXYOCTANEDIAMIDE; N1 [[4 (BENZYLCARBAMOYL) 6 BROMOQUINOLIN 2 YL]METHYL] N9 HYDROXYNONANEDIAMIDE; N1 [[4 (BENZYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N5 HYDROXYGLUTARAMIDE; N1 [[4 (BENZYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N6 HYDROXYADIPAMIDE; N1 [[4 (BENZYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N7 HYDROXYHEPTANEDIAMIDE; N1 [[4 (BENZYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N8 HYDROXYOCTANEDIAMIDE; N1 [[4 (BENZYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N9 HYDROXYNONANEDIAMIDE; N1 [[4 (BUTYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N7 HYDROXYHEPTANEDIAMIDE; N1 [[4 (BUTYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N8 HYDROXYOCTANEDIAMIDE; N1 [[6 BROMO 4 (PHENYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N7 HYDROXYHEPTANEDIAMIDE; N1 [[6 BROMO 4 (PHENYLCARBAMOYL)QUINOLIN 2 YL]METHYL] N8 HYDROXYOCTANEDIAMIDE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; HYDROXAMIC ACID; QUINOLINE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; TUMOR CELL LINE; BINDING SITE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937973886     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.024     Document Type: Article

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