Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis

Archives of Dermatological Research

Volumn 307, Issue 6, 2015, Pages 531-538

  Kim, Dae Suk ^a   Je, Jung Hwan ^a,b   Kim, Sung Hee ^a,b   Shin, Dongyun ^a   Kim, Tae Gyun ^a,b   Kim, Do Young ^a   Kim, Soo Min ^c   Lee, Min Geol ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c National Health Insurance Corporation   (South Korea)

Author keywords

Keratinocytes; Programmed death ligand 1, 2; Psoriasis

Indexed keywords

MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PDCD1 PROTEIN, HUMAN; PDCD1LG2 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LICHEN PLANUS; MALE; MIDDLE AGED; PITYRIASIS ROSEA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS VULGARIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN ALLERGY; SKIN BIOPSY; WESTERN BLOTTING; YOUNG ADULT; ADOLESCENT; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PSORIASIS; RADIATION RESPONSE;

ADOLESCENT; ADULT; BLOTTING, WESTERN; EPIDERMIS; FEMALE; GENE EXPRESSION; HUMANS; KERATINOCYTES; MALE; MIDDLE AGED; PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN; PROGRAMMED CELL DEATH 1 RECEPTOR; PSORIASIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 84937973387     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-015-1588-5     Document Type: Article

References (27)

1. Ainsworth C (2012) Immunology: a many layered thing. Nature 492:S52–S54
2. Bovenschen HJ, van Vlijmen-Willems IM, van de Kerkhof PC, van Erp PE (2006) Identification of lesional CD4+ÂCD25+ÂFoxp3+Âregulatory T cells in Psoriasis. Dermatology 213:111–117
3. Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M (2011) B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin. Cancer Res 71:1235–1243
4. Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M (2011) Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis. Cancer Res 71:4737–4741
5. Cetinozman F, Jansen PM, Willemze R (2014) Expression of programmed death-1 in skin biopsies of benign inflammatory vs. lymphomatous erythroderma. Br J Dermatol 171:499–504
6. Chu CC, Di Meglio P, Nestle FO (2011) Harnessing dendritic cells in inflammatory skin diseases. Semin Immunol 23:28–41
7. Crow JM (2012) Psoriasis uncovered. Nature 492:S50–S51
8. Du GH, Qin XP, Li Q, Zhou YM, Shen XM, Tang GY (2011) The high expression level of programmed death-1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells. J Oral Pathol Med 40:525–532
9. Francisco LM, Sage PT, Sharpe AH (2010) The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 236:219–242
10. Fujimura T, Ring S, Umansky V, Mahnke K, Enk AH (2012) Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas. J Invest Dermatol 132:1239–1246
11. Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, Homey B, Barrat FJ, Zal T, Gilliet M (2009) Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med 206:1983–1994
12. Gilliet M, Lande R (2008) Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr Opin Immunol 20:401–407
13. Keir ME, Butte MJ, Freeman GJ, Sharpe AH (2008) PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 26:677–704
14. Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH (2006) Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 203:883–895
15. Kim TG, Kim DS, Kim HP, Lee MG (2014) The pathophysiological role of dendritic cell subsets in psoriasis. BMB Rep 47:60–68
16. Koehn BH, Ford ML, Ferrer IR, Borom K, Gangappa S, Kirk AD, Larsen CP (2008) PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ÂT cells to transplanted tissue. J Immunol 181:5313–5322
17. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schroder JM, Liu YJ, Gilliet M (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564–569
18. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408
19. Lowes MA, Russell CB, Martin DA, Towne JE, Krueger JG (2013) The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 34:174–181
20. Lowes MA, Suarez-Farinas M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227–255
21. Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361:496–509
22. Okiyama N, Katz SI (2014) Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes. J Autoimmun 53:1–9
23. Ritprajak P, Hashiguchi M, Tsushima F, Chalermsarp N, Azuma M (2010) Keratinocyte-associated B7-H1 directly regulates cutaneous effector CD8+ÂT cell responses. J Immunol 184:4918–4925
24. Shehata IH, Elghandour TM (2007) A possible pathogenic role of CD4+ÂCD25+ÂT-regulatory cells in psoriasis. Egypt J Immunol 14:21–31
25. Soler DC, Sugiyama H, Young AB, Massari JV, McCormick TS, Cooper KD (2013) Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subset. Clin Immunol 149:111–118
26. Sugiyama H, Gyulai R, Toichi E, Garaczi E, Shimada S, Stevens SR, McCormick TS, Cooper KD (2005) Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 174:164–173
27. Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Machida U, Iwai H, Takahashi Y, Omura K, Yokozeki H, Azuma M (2004) The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. Immunol Lett 94:215–222