Association of Adiponectin with Body Composition and Mortality in Hemodialysis Patients

American Journal of Kidney Diseases

Volumn 66, Issue 2, 2015, Pages 313-321

  Rhee, Connie M ^a   Nguyen, Danh V ^b   Moradi, Hamid ^a   Brunelli, Steven M ^c   Dukkipati, Ramanath ^d   Jing, Jennie ^a   Nakata, Tracy ^a   Kovesdy, Csaba P ^e,f   Brent, Gregory A ^g   Kalantar Zadeh, Kamyar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DaVita Healthcare Partners Inc   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

anthropometry; body composition; body fat; body mass index (BMI); cardiovascular disease (CVD); end stage renal disease; hemodialysis; Index Words Adiponectin; lipids; MADRAD (Malnutrition, Diet, and Racial Disparities in Chronic Kidney Disease) study; mortality; renal replacement therapy (RRT)

Indexed keywords

ADIPONECTIN; CREATININE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; PHOSPHATE; SERUM ALBUMIN; TRIACYLGLYCEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE DISTRIBUTION; ALBUMIN BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT; CASE MIX; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CREATININE BLOOD LEVEL; ETHNICITY; FEMALE; HEMODIALYSIS PATIENT; HUMAN; IRON BINDING CAPACITY; LEUKOCYTE COUNT; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; RACE DIFFERENCE; SEX DIFFERENCE; SURVIVAL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; AGED; BLOOD; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; INTRAABDOMINAL FAT; KIDNEY FAILURE, CHRONIC; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; SUBCUTANEOUS FAT;

ADIPONECTIN; ADULT; AGED; BODY COMPOSITION; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; COHORT STUDIES; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MORTALITY; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RENAL DIALYSIS; SUBCUTANEOUS FAT; TRIGLYCERIDES;

EID: 84937966128     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2015.02.325     Document Type: Article

References (53)

1. M. Adamczak, and A. Wiecek The adipose tissue as an endocrine organ Semin Nephrol 33 1 2013 2 13
2. Y. Arita, S. Kihara, N. Ouchi, and et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1 1999 79 83
3. E.Z. Fisman, and A. Tenenbaum Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease? Cardiovasc Diabetol 13 103 2014 1 10
4. M. Chandran, S.A. Phillips, T. Ciaraldi, and R.R. Henry Adiponectin: more than just another fat cell hormone? Diabetes Care 26 8 2003 2442 2450
5. M. Cnop, P.J. Havel, K.M. Utzschneider, and et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex Diabetologia 46 4 2003 459 469
6. D.M. Maahs, L.G. Ogden, G.L. Kinney, and et al. Low plasma adiponectin levels predict progression of coronary artery calcification Circulation 111 6 2005 747 753
7. T. Pischon, C.J. Girman, G.S. Hotamisligil, N. Rifai, F.B. Hu, and E.B. Rimm Plasma adiponectin levels and risk of myocardial infarction in men JAMA 291 14 2004 1730 1737
8. M.B. Schulze, I. Shai, E.B. Rimm, T. Li, N. Rifai, and F.B. Hu Adiponectin and future coronary heart disease events among men with type 2 diabetes Diabetes 54 2 2005 534 539
9. D.C. Wheeler, R. Haynes, M.J. Landray, and C. Baigent Cardiovascular aspects of kidney disease M.W. Taal, G.M. Chertow, P.A. Marsden, K. Skorecki, A.S. Yu, B.M. Brenner, Taal: Brenner and Rector's The Kidney 9th ed. 2012 Elsevier Saunders Philadelphia, PA 2060 2075
10. M. Rao, L. Li, H. Tighiouart, B.L. Jaber, B.J. Pereira, and V.S. Balakrishnan Plasma adiponectin levels and clinical outcomes among haemodialysis patients Nephrol Dial Transplant 23 8 2008 2619 2628
11. C. Zoccali, F. Mallamaci, G. Tripepi, and et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease J Am Soc Nephrol 13 1 2002 134 141
12. J.J. Diez, P. Estrada, M.A. Bajo, and et al. High stable serum adiponectin levels are associated with a better outcome in prevalent dialysis patients Am J Nephrol 30 3 2009 244 252
13. C. Drechsler, V. Krane, K. Winkler, F.W. Dekker, and C. Wanner Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients Kidney Int 76 5 2009 567 575
14. V. Menon, L. Li, X. Wang, and et al. Adiponectin and mortality in patients with chronic kidney disease J Am Soc Nephrol 17 9 2006 2599 2606
15. N. Ohashi, A. Kato, T. Misaki, and et al. Association of serum adiponectin levels with all-cause mortality in hemodialysis patients Intern Med 47 6 2008 485 491
16. C. Tsigalou, G. Chalikias, K. Kantartzi, and et al. Differential effect of baseline adiponectin on all-cause mortality in hemodialysis patients depending on initial body mass index. Long-term follow-up data of 4.5 years J Ren Nutr 23 1 2013 45 56
17. C. Zoccali, M. Postorino, C. Marino, P. Pizzini, S. Cutrupi, and G. Tripepi Waist circumference modifies the relationship between the adipose tissue cytokines leptin and adiponectin and all-cause and cardiovascular mortality in haemodialysis patients J Intern Med 269 2 2011 172 181
18. K. Kalantar-Zadeh Causes and consequences of the reverse epidemiology of body mass index in dialysis patients J Ren Nutr 15 1 2005 142 147
19. C.X. Huang, H. Tighiouart, S. Beddhu, and et al. Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients Kidney Int 77 7 2010 624 629
20. J. Park, S.F. Ahmadi, E. Streja, and et al. Obesity paradox in end-stage kidney disease patients Prog Cardiovasc Dis 56 4 2014 415 425
21. M. Postorino, C. Marino, G. Tripepi, and C. Zoccali Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease J Am Coll Cardiol 53 15 2009 1265 1272
22. K. Kalantar-Zadeh, G. Block, T. Horwich, and G.C. Fonarow Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure J Am Coll Cardiol 43 8 2004 1439 1444
23. R.D. Kilpatrick, C.J. McAllister, C.P. Kovesdy, S.F. Derose, J.D. Kopple, and K. Kalantar-Zadeh Association between serum lipids and survival in hemodialysis patients and impact of race J Am Soc Nephrol 18 1 2007 293 303
24. H. Moradi, E. Streja, M.L. Kashyap, N.D. Vaziri, G.C. Fonarow, and K. Kalantar-Zadeh Elevated high-density lipoprotein cholesterol and cardiovascular mortality in maintenance hemodialysis patients Nephrol Dial Transplant 29 8 2014 1554 1562
25. H. Moradi, N.D. Vaziri, M.L. Kashyap, H.M. Said, and K. Kalantar-Zadeh Role of HDL dysfunction in end-stage renal disease: a double-edged sword J Ren Nutr 23 3 2013 203 206
26. E. Sevinc Ok, F. Kircelli, G. Asci, and et al. Neither oxidized nor anti-oxidized low-density lipoprotein level is associated with atherosclerosis or mortality in hemodialysis patients Hemodial Int 16 3 2012 334 341
27. J. Weber, and J. Kelley Assessing nutrition Health Assessment in Nursing 5th ed. 2009 Lippincott Williams & Wilkins Philadelphia, PA 150 169
28. N. Noori, J.D. Kopple, C.P. Kovesdy, and et al. Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients Clin J Am Soc Nephrol 5 12 2010 2258 2268
29. R. Bross, G. Chandramohan, C.P. Kovesdy, and et al. Comparing body composition assessment tests in long-term hemodialysis patients Am J Kidney Dis 55 5 2010 885 896
30. K. Kalantar-Zadeh, E. Dunne, K. Nixon, and et al. Near infra-red interactance for nutritional assessment of dialysis patients Nephrol Dial Transplant 14 1 1999 169 175
31. K. Kalantar-Zadeh, N. Kuwae, D.Y. Wu, and et al. Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients Am J Clin Nutr 83 2 2006 202 210
32. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc Ser B 57 1 1995 289 300
33. S.H. Park, J.J. Carrero, B. Lindholm, and P. Stenvinkel Adiponectin in chronic kidney disease has an opposite impact on protein-energy wasting and cardiovascular risk: two sides of the same coin Clin Nephrol 72 2 2009 87 96
34. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 8 2001 947 953
35. T. Yamauchi, J. Kamon, H. Waki, and et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat Med 7 8 2001 941 946
36. Y. Takemura, N. Ouchi, R. Shibata, and et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies J Clin Invest 117 2 2007 375 386
37. A.M. Wolf, D. Wolf, H. Rumpold, B. Enrich, and H. Tilg Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes Biochem Biophys Res Commun 323 2 2004 630 635
38. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M.J. Quon Adiponectin stimulates production of nitric oxide in vascular endothelial cells J Biol Chem 278 45 2003 45021 45026
39. H. Kobayashi, N. Ouchi, S. Kihara, and et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin Circ Res 94 4 2004 e27 e31
40. N. Ouchi, S. Kihara, Y. Arita, and et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages Circulation 103 8 2001 1057 1063
41. N. Ouchi, S. Kihara, Y. Arita, and et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 11 2000 1296 1301
42. J.W. Huang, C.J. Yen, H.W. Chiang, K.Y. Hung, T.J. Tsai, and K.D. Wu Adiponectin in peritoneal dialysis patients: a comparison with hemodialysis patients and subjects with normal renal function Am J Kidney Dis 43 6 2004 1047 1055
43. G.M. van der Vleuten, L.J. van Tits, M. den Heijer, H. Lemmers, A.F. Stalenhoef, and J. de Graaf Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile J Lipid Res 46 11 2005 2398 2404
44. W.S. Yang, W.J. Lee, T. Funahashi, and et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin J Clin Endocrinol Metab 86 8 2001 3815 3819
45. Y. Qi, N. Takahashi, S.M. Hileman, and et al. Adiponectin acts in the brain to decrease body weight Nat Med 10 5 2004 524 529
46. T. Jia, J.J. Carrero, B. Lindholm, and P. Stenvinkel The complex role of adiponectin in chronic kidney disease Biochimie 94 10 2012 2150 2156
47. G.A. Kaysen, P. Kotanko, F. Zhu, and et al. Relationship between adiposity and cardiovascular risk factors in prevalent hemodialysis patients J Ren Nutr 19 5 2009 357 364
48. J. Smiechowska, A. Utech, G. Taffet, T. Hayes, M. Marcelli, and J.M. Garcia Adipokines in patients with cancer anorexia and cachexia J Invest Med 58 3 2010 554 559
49. P. Stenvinkel, A. Marchlewska, R. Pecoits-Filho, and et al. Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin Kidney Int 65 1 2004 274 281
50. T.S. Tsao, E. Tomas, H.E. Murrey, and et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways J Biol Chem 278 50 2003 50810 50817
51. O. Tsukamoto, M. Fujita, M. Kato, and et al. Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure J Am Coll Cardiol 53 22 2009 2070 2077
52. A.A. Richards, T. Stephens, H.K. Charlton, and et al. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications Mol Endocrinol 20 7 2006 1673 1687
53. Y.Y. Shen, J.A. Charlesworth, J.J. Kelly, and P.W. Peake The effect of renal transplantation on adiponectin and its isoforms and receptors Metab Clin Exp 56 9 2007 1201 1208