Synthesis and biological activity of two C.7 methyl analogues of Vitamin D

Journal of Organic Chemistry

Volumn 80, Issue 1, 2015, Pages 165-173

  Sokolowska, Katarzyna ^a   Carballa, Diego ^b   Seoane, Samuel ^c   Pérez Fernández, Román ^c   Mouriño, Antonio ^b   Sicinski, Rafal R ^a  

^a UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c Universidade de Santiago de Compostela and Instituto de Investigación Sanitaria de Santiago de Compostela   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CYCLIZATION; ENERGY DISPERSIVE X RAY ANALYSIS; REGIOSELECTIVITY; VITAMINS; X RAY DIFFRACTION ANALYSIS;

BINDING ABILITIES; FUNCTIONALIZATIONS; HYDROSTANNYLATION; INTRAMOLECULAR CYCLIZATIONS; PALLADIUM-CATALYZED; REGIO-SELECTIVE; SUZUKI-MIYAURA COUPLING; THERMAL EQUILIBRATIONS;

BIOSYNTHESIS;

1 [(BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)HEXYL] 7A METHYL 4 (1'' IODOETHYLIDEN) OCTAHYDRO INDENE; 1 [(BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)HEXYL] 7A METHYL 4 METHYLENE OCTAHYDRO INDENE; 1 [(BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)HEXYL] 7A METHYL 4 [1'' (4''',4''',5''',5''' TETRAMETHYL 1''',3''' DIOXA 2''' BOROLAN 2''' YL)ETHYLIDENE] OCTAHYDRO INDENE; 1 [(BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)HEXYL] 7A METHYL 4 [1'' (4''',4''',5''',5''' TETRAMETHYL 1''',3''' DIOXA 2''' BOROLAN 2'''YL)ETHYLIDENE] OCTAHYDRO INDENE; 1 [(BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)SHYHEXYL] 7A METHYL 4 ETHENYLIDENE OCTAHYDRO INDENE; 1 [5' (BENZYLDIMETHYLSILYL)OXY 1',5' (DIMETHYL)HEXYL] 7A METHYL OCTAHYDRO INDEN 4 ONE; 1' [1'',5'' DIMETHYL 5'' [(TRIETHYLSILYL)OXY] HEXYL] 7A' METHYLOCTAHYDRO INDEN (4'E) YLIDENE] ACETONITRILE; 1ALPHA [TERT BUTYLDIMETHYLSILYL)OXY] 25 [(TRIETHYLSILYL)OXY] 7 METHYL 19 NORVITAMIN D3 TERT BUTYLDIMETHYLSILYL ETHER; 1ALPHA,25 DIHYDROXY 7 METHYL 19 NORVITAMIN D3; 1ALPHA,25 DIHYDROXY 7 METHYL VITAMIN D3; 2 [1' [1'',5'' DIMETHYL 5'' [(TRIETHYLSILYL)OXY]HEXYL] 7A' METHYLOCTAHYDRO INDEN (4'E) YLIDENE] PROPAN 1 OL; 2 [1' [1'',5'' DIMETHYL 5'' [(TRIETHYLSILYL)OXY]HEXYL] 7A' METHYLOCTAHYDRO INDEN (4'E) YLIDENE] PROPIONALDEHYDE; 2 [1' [1'',5'' DIMETHYL 5'' [(TRIETHYLSILYL)OXY]HEXYL] 7A' METHYLOCTAHYDRO INDEN (4'E) YLIDENE] PROPIONITRILE; 2 [2 [1''[1'',5''' DIMETHYL 5''' [(TRIETHYLSILYL)OXY]HEXYL] 7A'' METHYL OCTAHYDRO INDEN (4'E) YLIDENE] PROPANE 1' SULFONYL] BENZOTHIAZOLE; ALKADIENE; CALCITRIOL; METHYL GROUP; PALLADIUM; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; CALCITRIOL RECEPTOR; VITAMIN D;

ARTICLE; BIOLOGICAL ACTIVITY; CATALYST; CYCLIZATION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; ULTRAVIOLET SPECTROSCOPY; X RAY ANALYSIS; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; STEREOISOMERISM; SYNTHESIS;

MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D;

EID: 84937965897     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo502243r     Document Type: Article

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