Herbal formula Danggui-Shaoyao-San promotes neurogenesis and angiogenesis in rat following middle cerebral artery occlusion

Aging and Disease

Volumn 6, Issue 4, 2015, Pages 245-253

  Ren, Changhong ^a,b   Wang, Brian ^b   Li, Ning ^a   Jin, Kunlin ^b   Ji, Xunming ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Angiogenesis; Dangui Shaoyao San; Ischemic stroke; Neurogenesis

Indexed keywords

ALISMA ORIENTALIS EXTRACT; ANGELICA SINENSIS EXTRACT; ATRACTYLODES MACROCEPHALA EXTRACT; DANGGUI SHAOYAO SAN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HERBACEOUS AGENT; LIGUSTICUM CHUANXIONG EXTRACT; NEUROPROTECTIVE AGENT; PAEONIA LACTIFLORA EXTRACT; PORIA COCOS EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ALISMA ORIENTALIS; ANGELICA SINENSIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATRACTYLODES MACROCEPHALA; BRAIN INJURY; BRAIN ISCHEMIA; CAPILLARY DENSITY; CELL COUNT; CHINESE MEDICINE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL BEHAVIORAL TEST; FEMALE; HERBAL MEDICINE; IMMUNOHISTOCHEMISTRY; LIGUSTICUM CHUANXIONG; MEDICINAL PLANT; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PAEONIA LACTIFLORA; PHOSPHORYLATION; PORIA COCOS; PROTEIN EXPRESSION; RAT; REPERFUSION; TREATMENT OUTCOME; WESTERN BLOTTING;

RATTUS;

EID: 84937948808     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.1126     Document Type: Article

References (37)

1. Moskowitz MA, Lo EH, Iadecola C (2010). The science of stroke: mechanisms in search of treatments. Neuron, 67: 181-198.
2. Arai K, Jin G, Navaratna D, Lo EH (2009). Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. The FEBS journal, 276: 4644-4652.
3. Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, et al. (2014). Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Progress in neurobiology, 115: 138-156.
4. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM (1994). Role of angiogenesis in patients with cerebral ischemic stroke. Stroke; a journal of cerebral circulation, 25: 1794-1798.
5. Wang L, Zhang Z, Wang Y, Zhang R, Chopp M (2004). Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke; a journal of cerebral circulation, 35: 1732-1737.
6. Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, et al. (2002). Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke; a journal of cerebral circulation, 33: 2675-2680.
7. Itoh T, Michijiri S, Murai S, Saito H, Nakamura K, Itsukaichi O, et al. (1996). Regulatory effect of danggui-shaoyao-san on central cholinergic nervous system dysfunction in mice. The American journal of Chinese medicine, 24: 205-217.
8. Inanaga K (2007). [Aging in brain and mind-drug therapy for patients with behavioral and psychological symptoms of dementia (BPSD)]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 109: 703-708.
9. Higaki S, Toyomoto T, Morohashi M (2002). Seijo-bofu-to, Jumi-haidoku-to and Toki-shakuyaku-san suppress rashes and incidental symptoms in acne patients. Drugs under experimental and clinical research, 28: 193-196.
10. Pu F, Mishima K, Egashira N, Akiyoshi Y, Liu AX, Sano K, et al. (2005). Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats. The American journal of Chinese medicine, 33: 475-489.
11. Chung MH, Suzuki S, Nishihara T, Hattori M (2008). Estrogenic effects of a Kampo formula, Tokishakuyakusan, in parous ovariectomized rats. Biological & pharmaceutical bulletin, 31: 1145-1149.
12. Matsuoka T, Narumoto J, Shibata K, Okamura A, Taniguchi S, Kitabayashi Y, et al. (2012). Effect of toki-shakuyaku-san on regional cerebral blood flow in patients with mild cognitive impairment and Alzheimer's disease. Evidence-based complementary and alternative medicine: eCAM, 2012: 245091.
13. Huang Y, Hu ZY, Yuan H, Shu L, Liu G, Qiao SY, et al. (2014). Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol. Evidence-based complementary and alternative medicine: eCAM, 2014: 327294.
14. Lan Z, Liu J, Chen L, Fu Q, Luo J, Qu R, et al. (2012). Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice. Journal of ethnopharmacology, 141: 386-395.
15. Kitabayashi Y, Shibata K, Nakamae T, Narumoto J, Fukui K (2007). Effect of traditional Japanese herbal medicine toki-shakuyaku-san for mild cognitive impairment: SPECT study. Psychiatry and clinical neurosciences, 61: 447-448.
16. Huang Z, Mao QQ, Zhong XM, Li ZY, Qiu FM, Ip SP (2012). Mechanistic study on the antidepressant-like effect of danggui-shaoyao-san, a Chinese herbal formula. Evidence-based complementary and alternative medicine: eCAM, 2012: 173565.
17. Zhou S, Wang Q, Zhu D (2007). The effect of optimized Danggui Shaoyao San (FBD) on cerebral ischemia reperfusion. Chinese journal of experimental traditional medical formulae, 12: 47-50.
18. Wang Q, Xu Z, Chen G (2013). Protective effect of medicinal serum of Danggui Shaoyao Powder on myocardial cell injury of rats China pharmacy 24: 2893-2895.
19. Hatip-Al-Khatib I, Hatip FB, Yoshimitsu Y, Iwasaki K, Egashira N, Liu AX, et al. (2007). Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and twice-repeated ischemic rats. Phytotherapy research: PTR, 21: 291-294.
20. Greenberg DA, Jin K (2013). Vascular endothelial growth factors (VEGFs) and stroke. Cellular and molecular life sciences: CMLS, 70: 1753-1761.
21. Greenberg DA, Jin K (2005). From angiogenesis to neuropathology. Nature, 438: 954-959.
22. Ma Y, Zechariah A, Qu Y, Hermann DM (2012). Effects of vascular endothelial growth factor in ischemic stroke. Journal of neuroscience research, 90: 1873-1882.
23. Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C, et al. (1998). Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. The Journal of clinical investigation, 101: 2567-2578.
24. Bir SC, Xiong Y, Kevil CG, Luo J (2012). Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases. Cardiovascular research, 95: 7-18.
25. Chen J, Zacharek A, Zhang C, Jiang H, Li Y, Roberts C, et al. (2005). Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. The Journal of neuroscience: the official journal of the Society for Neuroscience, 25: 2366-2375.
26. Zwagerman N, Plumlee C, Guthikonda M, Ding Y Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol Res, 32: 123-126.
27. Belayev L, Alonso OF, Busto R, Zhao W, Ginsberg MD (1996). Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke, 27: 1616-1622; discussion 1623.
28. Borlongan CV, Sanberg PR (1995). Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism. The Journal of neuroscience: the official journal of the Society for Neuroscience, 15: 5372-5378.
29. Jin K, Sun Y, Xie L, Peel A, Mao XO, Batteur S, et al. (2003). Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci, 24: 171-189.
30. Song QH, Toriizuka K, Jin GB, Yabe T, Cyong JC (2001). Long term effects of Toki-shakuyaku-san on brain dopamine and nerve growth factor in olfactory-bulb-lesioned mice. Japanese journal of pharmacology, 86: 183-188.
31. Chen J, Chopp M (2006). Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRx: the journal of the American Society for Experimental NeuroTherapeutics, 3: 466-473.
32. Zhang E, Shen J, So KF (2014). Chinese traditional medicine and adult neurogenesis in the hippocampus. Journal of traditional and complementary medicine, 4: 77-81.
33. Chen L, Wang X, Chen X, Xing S, Zhang J, Li J, et al. (2014). Tongxinluo attenuates neuronal loss and enhances neurogenesis and angiogenesis in the ipsilateral thalamus and improves neurological outcome after focal cortical infarction in hypertensive rats. Restorative neurology and neuroscience, 32: 533-546.
34. Shen J, Zhu Y, Yu H, Fan ZX, Xiao F, Wu P, et al. (2014). Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia. Journal of Zhejiang University. Science. B, 15: 272-280.
35. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, et al. (2003). VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. The Journal of clinical investigation, 111: 1843-1851.
36. Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al. (2000). VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. The Journal of clinical investigation, 106: 829-838.
37. Ma FX, Han ZC (2005). Statins, nitric oxide and neovascularization. Cardiovascular drug reviews, 23: 281-292.