The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Science Translational Medicine

Volumn 7, Issue 297, 2015, Pages

  Prokai, Laszlo ^a,b   Nguyen, Vien ^a   Szarka, Szabolcs ^a,h   Garg, Puja ^a,c,i   Sabnis, Gauri ^d   Bimonte Nelson, Heather A ^e,f   McLaughlin, Katie J ^e,j   Talboom, Joshua S ^e,f   Conrad, Cheryl D ^e   Shughrue, Paul J ^g,k   Gould, Todd D ^d   Brodie, Angela ^d   Merchenthaler, Istvan ^d   Koulen, Peter ^c   Prokai Tatrai, Katalin ^a,b  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b AgyPharma LLC   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e ARIZONA STATE UNIVERSITY   (United States)

^f ARIZONA ALZHEIMER S CONSORTIUM   (United States)

^g ELAN PHARMACEUTICALS   (United States)

^h LGC   (United Kingdom)

ⁱ UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^j ELI LILLY AND COMPANY   (United States)

^k Prothena Biosciences Inc   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

10BETA,17BETA DIHYDROXYESTRA 1,4 DIEN 3 ONE; ESTRADIOL; PRODRUG; UNCLASSIFIED DRUG; 3,16-DIHYDROXYANDROST-5-ENE-17,19-DIONE; ANDROSTENEDIOL DERIVATIVE; ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL STRUCTURE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; BRAIN ISCHEMIA; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HUMAN; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; STROKE; UTERUS;

ANDROSTENEDIOLS; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOMARKERS; BRAIN; BRAIN ISCHEMIA; BREAST NEOPLASMS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGENS; FEMALE; HUMANS; MCF-7 CELLS; NEUROPROTECTION; PRODRUGS; STROKE; UTERUS;

EID: 84937867876     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aab1290     Document Type: Article

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