Neuroprotection by estrogen in animal models of ischemia and Parkinson's disease

Drug Development Research

Volumn 66, Issue 2, 2005, Pages 172-181

  Merchenthaler, Istvan ^a   Shughrue, Paul J ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Animal model; Ischemia; Neurodegeneration; Stroke

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA TOCOPHEROL; ANTIESTROGEN; ANTIOXIDANT; DIETHYLSTILBESTROL; DNA; DOPAMINE TRANSPORTER; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; FULVESTRANT; MESSENGER RNA; NEUROGRANIN; NEUROTOXIN; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; ESTROGEN ACTIVITY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; REVIEW; STROKE;

EID: 33644846946     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20056     Document Type: Review

References (43)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hum PD. 1998. Gender-linked brain injury in experimental stroke. Stroke 29:159-165 (see also discussion on p 166).
2. Ascherio A, Chen H, Schwarzschild MA, Zhang SM, Colditz GA, Speizer FE. 2003. Caffeine, postmenopausal estrogen, and risk of Parkinsons disease. Neurology 60:790-795.
3. Baldereschi M, Di Carlo A, Rocca WA, Vanni P, Maggi S, Perissinotto E, Grigoletto F, Amaducci L, Inzitari D. 2000. Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group. Italian Longitudinal Study on Aging. Neurology 55:1358-1363.
4. Behl C. 2002. Oestrogen as a neuroprotective hormone. Nature Rev Neurosci 3:433-442.
5. Benedetti MD, Maraganore DM, Bower JH, McDonnell SK, Peterson BJ, Ahlskog JE, Schaid DJ, Rocca WA. 2001. Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study. Move Dis 16: 830-837.
6. Blurton-Jones M, Tuszynski MH. 2001. Reactive astrocytes express estrogen receptors in the injured primate brain. J Comp Neurol 433:115-123.
7. Bower JH, Maraganore DM, McDonnell SK, Rocca WA. 1999. Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990. Neurology 52:1214-1220.
8. Bredesen DE. 1995. Neural apoptosis. Ann Neurol 38:839-851.
9. Callier S, Morissette M, Grandbois M, Pelaprat D, Di Paolo T. 2001. Neuroprotective properties of 17β-estradiol, progesterone, and raloxifene in MPTP C57B1/6 mice. Synapse 41:131-138.
10. Choi DW. 1996. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6:667-672.
11. D'Astous M, Morissette M, Tanguay B, Callier S, Di Paolo T. 2003. Dehydroepiandrosterone DHEA such as 17β-estradiol prevents MPTP-induced dopamine depletion in mice. Synapse 47:10-14.
12. Diamond SG, Markham CH, Hoehn MM, McDowell FH, Muenter MD. 1990. An examination of male-female differences in progression and mortality of Parkinson's disease. Neurology 40:763-766.
13. Dluzen DE, McDermott JL, Liu B. 1996. Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice. Neurotox Teratol 18:603-606.
14. Dluzen DE, McDermott JL, Anderson LI. 2001. Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice. J Neuroendocrinol 13:618-624.
15. Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM. 1998. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 18:1253-1258.
16. Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. 1999. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 19:6385-6393.
17. Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. 2001. Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci USA 98:1952-1957.
18. Garcia-Segura LM, Azcoitia I, DonCarlos LL. 2001. Neuroprotection by estradiol. Prog Neurobiol 63:29-60.
19. Graham SH, Chen J. 2001. Programmed cell death in cerebral ischemia. J Cereb Blood Flow Metab 21:99-109.
20. Grandbois M, Morissette M, Callier S, Di Paolo T. 2000. Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice. Neuroreport 11:343-346.
21. Green PS, Gordon K, Simpkins JW. 1997. Phenolic A ring requirement for the neuroprotective effects of steroids. J Steroid Biochem Mol Biol 63:229-235.
22. Horstink MW, Strijks E, Dluzen DE. 2003. Estrogen and Parkinson's disease, Adv Neurol 91:107-114.
23. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. 1994. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885.
24. Koch M, Ehret G. 1989. Immunocytochemical localization and quantitation of estrogen-binding cells in the male and female virgin, pregnant, lactating mouse brain. Brain Res 489:101-112.
25. Leker RR, Shohami E. 2002. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev 39:55-73.
26. MacManus JP, Buchan AM. 2000. Apoptosis after experimental stroke: fact or fashion? J Neurotrauma 17:899-914.
27. MacManus JP, Linnik MD. 1997. Gene expression induced by cerebral ischemia: an apoptotic perspective. J Cereb Blood Flow Metab 17:815-832.
28. Merchenthaler I, Dellovade TL, Shughrue PJ. 2003. Neuroprotection by estrogen in animal models of global and focal ischemia. Ann NY Acad Sci 1007:89-100.
29. Merchenthaler I, Lane MV, Numan S, Dellovade TL. 2004. Distribution of estrogen receptor α and β in the mouse central nervous system: in vivo autoradiographic and immunocytochemical analyses. J Comp Neurol 473:270-291.
30. Merry DE, Korsmeyer SJ. 1997. Bcl-2 gene family in the nervous system. Ann Rev Neurosci 20:245-267.
31. Moosmann B, Behl C. 1999. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci USA 96:8867-8872.
32. Murray HE, Pillai AV, McArthur SR, Razvi N, Datla KP, Dexter DT, Gillies GE. 2003. Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats : differential actions of estrogen in males and females. Neuroscience 116:213-222.
33. Saleh TM, Alastair EC, Connell BJ. 2001. Reduction in infarct size by local estrogen does not prevent autonomic dysfunction after stroke. Am J Physiol Regul Integr Comp Physiol 281:2088-2095.
34. Shughrue PJ. 2004. Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERα and ERβ). Exp Neurol 190:468-477.
35. Shughrue PJ, Merchenthaler I. 2000. Estrogen is more than just a "Sex Hormone": novel sites for estrogen action in the hippocampus and cerebral cortex. Front Neuroendocrinol 21:95-101.
36. Shughrue PJ, Merchenthaler I. 2003. Estrogen prevents the loss of CAl hippocampal neurons in gerbils after ischemic injury. Neuroscience 116:851-861.
37. 125I]iodoestradiol. Endocrinology 126:1112-1124.
38. Shughrue PJ, Lane MV. Merchenthaler I. 1997. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525.
39. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL. 1997. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 87:724-730.
40. Tanaka H, Grooms SY, Bennett MV, Zukin RS. 2000. The AMPAR subunit GluR2: still front and center-stage. Brain Res 886:190-207.
41. Teixeira C, Reed JC, Pratt MA. 1995. Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55:3902-3907.
42. Wise PM, Dubal DB, Wilson ME, Rau SW, Liu Y. 2001. Estrogens: trophic and protective factors in the adult brain. Front Neuroendocrinol 22:33-66.
43. Yang SH, Shi J, Day AL, Simpkins JW. 2000. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke 31:745-749 (discussion on p 749-750).