Directly reconstructing principal components of heterogeneous particles from cryo-EM images

Journal of Structural Biology

Volumn 191, Issue 2, 2015, Pages 245-262

  Tagare, Hemant D ^a   Kucukelbir, Alp ^b,c   Sigworth, Fred J ^a,d   Wang, Hongwei ^e   Rao, Murali ^f  

^a YALE UNIVERSITY   (United States)

^b Columbia University ^*  (United States)

^c Department of Earth and Environmental Sciences   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TSINGHUA UNIVERSITY   (China)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

EM algorithm; Heterogeneity; Maximum likelihood; Principal components; Single particle reconstruction

Indexed keywords

70S RIBOSOME PROTEIN; DIMER; ELONGATION FACTOR G; RIBOSOME PROTEIN; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; CONFORMATIONAL TRANSITION; COVARIANCE; CRYOELECTRON MICROSCOPY; EXPECTATION MAXIMIZATION ALGORITHM; FOURIER ANALYSIS; IMAGE RECONSTRUCTION; INFLUENZA VIRUS; NONHUMAN; PARTICLE SIZE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN ANALYSIS; PROTEIN BINDING; STATISTICAL ANALYSIS; THREE DIMENSIONAL IMAGING; CHEMISTRY; COMPUTER SIMULATION; ENZYMOLOGY; INFLUENZA A VIRUS; MOLECULAR MODEL; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; RIBOSOME; STATISTICAL MODEL; ULTRASTRUCTURE;

ORTHOMYXOVIRIDAE;

ALGORITHMS; COMPUTER SIMULATION; CRYOELECTRON MICROSCOPY; INFLUENZA A VIRUS; LIKELIHOOD FUNCTIONS; MODELS, MOLECULAR; PRINCIPAL COMPONENT ANALYSIS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES; RNA REPLICASE;

EID: 84937812885     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2015.05.007     Document Type: Article

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